التداخل بين نوريثيستيرون وإيثينيل إستراديول وبيرامبانيل

CYP3A4 inhibitors such as itraconazole or ketoconazole may increase plasma hormone levels.

Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel ( 7.1 )

Contraceptives With concomitant use, FYCOMPA at a dose of 12 mg per day reduced levonorgestrel exposure by approximately 40% [see Clinical Pharmacology (12.3) ] .

Use of FYCOMPA with contraceptives containing levonorgestrel may render them less effective.