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Wechselwirkungen von Dutasterid

Dutasterid (Avodart), ein 5-Alpha-Reduktasehemmer, hat in den von uns erfassten FDA-Fachinformationen und Faktenblättern 67 dokumentierte Wechselwirkungen: 2 schwerwiegende, 20 mittelschwere, 35 geringfügige und 10, bei denen eine Fachinformation keine relevante Wechselwirkung berichtet. Jeder Eintrag unten zitiert den Satz, auf dem er beruht. Diese Medikamentenseite ist ein Ausgangspunkt, kein Urteil über Ihre persönliche Situation.

Wechselwirkungen laut Fachinformation

Schwerwiegende Wechselwirkungen (2)

  • Dutasterid und Tamsulosin5-Alpha-ReduktasehemmerSchwerwiegend

    Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride or other 5 alpha-reductase inhibitors [see Adverse Reactions (6.2) ]. (Fachinformation zu Dutasterid, Gegenanzeigen)

  • Finasterid5-Alpha-ReduktasehemmerSchwerwiegend

    Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride or other 5 alpha-reductase inhibitors [see Adverse Reactions (6.2) ]. (Fachinformation zu Dutasterid, Gegenanzeigen)

Mittelschwere Wechselwirkungen (20)

  • AmlodipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Amlodipin und AtorvastatinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Amlodipin und BenazeprilDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Amlodipin und OlmesartanDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Amlodipin und ValsartanDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • DigoxinDigitalisglykosidMittelschwer

    Digoxin Dutasteride capsules do not alter the steady-state pharmacokinetics of digoxin when administered concomitantly at a dose of 0.5 mg/day for 3 weeks [see Clinical Pharmacology (12.3) ]. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • DiltiazemCalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • FelodipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • IsradipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • ItraconazolAzol-AntimykotikumMittelschwer

    Dutasteride Oxybutynin Sildenafil (for erectile dysfunction) Tadalafil (for erectile dysfunction and benign prostatic hyperplasia) Tolterodine Monitor for adverse reactions. (Fachinformation zu Itraconazol, Arzneimittelwechselwirkungen)

  • Lopinavir und Ritonavirantiretrovirales ArzneimittelMittelschwer

    Use with caution in patients taking potent, chronic cytochrome P450 (CYP)3A4 enzyme inhibitors (e.g., ritonavir). (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • NicardipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • NifedipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • NimodipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Nirmatrelvir und RitonavirVirostatikumMittelschwer

    Use with caution in patients taking potent, chronic cytochrome P450 (CYP)3A4 enzyme inhibitors (e.g., ritonavir). (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • NisoldipinDihydropyridin-CalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Olmesartan, Amlodipin und HydrochlorothiazidAngiotensin-II-Rezeptorblocker (Sartan)Mittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Ritonavirantiretrovirales ArzneimittelMittelschwer

    Use with caution in patients taking potent, chronic cytochrome P450 (CYP)3A4 enzyme inhibitors (e.g., ritonavir). (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Telmisartan und AmlodipinAngiotensin-II-Rezeptorblocker (Sartan)Mittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • VerapamilCalciumkanalblockerMittelschwer

    Calcium Channel Antagonists Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

Geringfügige Erwähnungen (35)

  • AmiodaronAntiarrhythmikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • AprepitantCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Atazanavirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • CenobamatAntiepileptikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • CiclosporinImmunsuppressivumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • CimetidinH2-BlockerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • ClarithromycinMakrolid-AntibiotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Darunavirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Darunavir und Cobicistatantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • DronedaronAntiarrhythmikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Efavirenzantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Efavirenz, Lamivudin und Tenofovirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Elvitegravir, Cobicistat, Emtricitabin und Tenofovirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • ErythromycinMakrolid-AntibiotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • EverolimusImmunsuppressivumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • FluconazolAzol-AntimykotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Fosamprenavirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • FosaprepitantCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • ImatinibCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • IsoniazidAntibiotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • IvacaftorCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • KetoconazolAzol-AntimykotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • Lenacapavirantiretrovirales ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • MifepristonCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • MirabegronBeta-Adrenozeptor-AgonistGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • NefazodonAntidepressivumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PalbociclibCYP3A4-HemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PerampanelAntiepileptikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PosaconazolAzol-AntimykotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • RanolazinQT-verlängerndes ArzneimittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • SuvorexantSchlaf- und BeruhigungsmittelGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • TamsulosinAlphablockerGeringfügig

    Coadministration of dutasteride and tamsulosin resulted in similar changes to serum PSA as dutasteride monotherapy. (Fachinformation zu Dutasterid, Warnhinweise und Vorsichtsmaßnahmen)

  • TerazosinAlphablockerGeringfügig

    The effect of administration of tamsulosin or terazosin on dutasteride pharmacokinetic parameters has not been evaluated. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • TicagrelorThrombozytenaggregationshemmerGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • VoriconazolAzol-AntimykotikumGeringfügig

    The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

Keine relevante Wechselwirkung berichtet (10)

  • AlfuzosinAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • CarvedilolBetablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • ColestyraminGallensäurebinderKeine Wechselwirkung

    Cholestyramine Administration of a single 5-mg dose of dutasteride capsules followed 1 hour later by 12 g of cholestyramine does not affect the relative bioavailability of dutasteride [see Clinical Pharmacology (12.3) ]. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • DoxazosinAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • LabetalolBetablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PhenoxybenzaminAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PhentolaminAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • PrazosinAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • SilodosinAlphablockerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

  • WarfarinAntikoagulans (Gerinnungshemmer)Keine Wechselwirkung

    Warfarin Concomitant administration of dutasteride capsules 0.5 mg/day for 3 weeks with warfarin does not alter the steady-state pharmacokinetics of the S- or R-warfarin isomers or alter the effect of warfarin on prothrombin time [see Clinical Pharmacology (12.3) ]. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

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Im Wechselwirkungscheck öffnen

Keine medizinische Beratung. Der Schweregrad gibt die Formulierung der Fachinformation wieder, nicht Ihre persönlichen Umstände. Eine als „schwerwiegend“ eingestufte Wechselwirkung kann unter Aufsicht Routine sein, und eine „geringfügige“ kann bei hohen Dosen von Bedeutung sein. Fragen Sie in einer Apotheke nach.