Wechselwirkungen von Piperacillin und Tazobactam

AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Fachinformation zu Amoxicillin, Gegenanzeigen)

History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AUGMENTIN or to other beta‑lactams (e.g., penicillins or cephalosporins). (Fachinformation zu Amoxicillin und Clavulansäure, Gegenanzeigen)

CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Fachinformation zu Ampicillin, Gegenanzeigen)

CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Fachinformation zu Ampicillin und Sulbactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Fachinformation zu Piperacillin und Tazobactam, Gegenanzeigen)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Fachinformation zu Demeclocyclin, Arzneimittelwechselwirkungen)

Avoid co-administration of tetracyclines with penicillin. (Fachinformation zu Doxycyclin, Arzneimittelwechselwirkungen)

INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (Fachinformation zu Ertapenem, Gegenanzeigen)

Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (Fachinformation zu Imipenem und Cilastatin, Warnhinweise und Vorsichtsmaßnahmen)

Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Fachinformation zu Minocyclin, Arzneimittelwechselwirkungen)

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection and Sodium Chloride Injection unless the benefit outweighs the risk. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection and Sodium Chloride Injection unless the benefit outweighs the risk. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Fachinformation zu Tetracyclin, Arzneimittelwechselwirkungen)

In vivo inactivation : When aminoglycosides are administered in conjunction with piperacillin to patients with end-stage renal disease requiring hemodialysis, the concentrations of the aminoglycosides (especially tobramycin) may be significantly reduced and should be monitored. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (Fachinformation zu Aztreonam, Warnhinweise und Vorsichtsmaßnahmen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Benazepril und Hydrochlorothiazid, Warnhinweise)

Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Bisoprolol und Hydrochlorothiazid, Warnhinweise)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Candesartan und Hydrochlorothiazid, Warnhinweise)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Fachinformation zu Colestipol, Arzneimittelwechselwirkungen)

Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Fachinformation zu Colestyramin, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (Fachinformation zu Diclofenamid, Arzneimittelwechselwirkungen)

Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Enalapril und Hydrochlorothiazid, Warnhinweise)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Increased Transaminase Levels In Trial 1, increases in transaminases occurred more frequently in CONTEPO-treated patients compared to piperacillin/tazobactam-treated patients. (Fachinformation zu Fosfomycin, Warnhinweise und Vorsichtsmaßnahmen)

In vivo inactivation : When aminoglycosides are administered in conjunction with piperacillin to patients with end-stage renal disease requiring hemodialysis, the concentrations of the aminoglycosides (especially tobramycin) may be significantly reduced and should be monitored. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Irbesartan und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Fachinformation zu Leflunomid, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Lisinopril und Hydrochlorothiazid, Warnhinweise)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Losartan und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Methotrexate Limited data suggests that co-administration of methotrexate and piperacillin may reduce the clearance of methotrexate due to competition for renal secretion. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Metoprolol und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (Fachinformation zu Mycophenolat, Arzneimittelwechselwirkungen)

Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

In vivo inactivation : When aminoglycosides are administered in conjunction with piperacillin to patients with end-stage renal disease requiring hemodialysis, the concentrations of the aminoglycosides (especially tobramycin) may be significantly reduced and should be monitored. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Olmesartan und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Olmesartan, Amlodipin und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

In vivo inactivation : When aminoglycosides are administered in conjunction with piperacillin to patients with end-stage renal disease requiring hemodialysis, the concentrations of the aminoglycosides (especially tobramycin) may be significantly reduced and should be monitored. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (Fachinformation zu Protamin, Vorsichtsmaßnahmen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Quinapril und Hydrochlorothiazid, Warnhinweise)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Salicylate competes with a number of drugs for protein binding sites, notably penicillin, thiopental, thyroxine, triiodothyronine, phenytoin, sulfinpyrazone, naproxen, warfarin, methotrexate, and possibly corticosteroids. [When Salsalate tablets, USP are administered with aspirin, its protein binding is reduced, although the clearance of free Salsalate tablets,… (Fachinformation zu Salsalat, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Spironolacton und Hydrochlorothiazid, Warnhinweise)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Telmisartan und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Fachinformation zu Teriflunomid, Arzneimittelwechselwirkungen)

Piperacillin and Tazobactam for Injection and Sodium Chloride Injection administration can significantly reduce tobramycin concentrations in hemodialysis patients. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

…from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (Fachinformation zu Triamteren, Arzneimittelwechselwirkungen)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Triamteren und Hydrochlorothiazid, Warnhinweise)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Fachinformation zu Valsartan und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

Combined use of piperacillin and tazobactam and vancomycin may be associated with an increased incidence of acute kidney injury [see Drug Interactions (7.3) ]. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Vecuronium Piperacillin when used concomitantly with vecuronium has been implicated in the prolongation of the neuromuscular blockade of vecuronium. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Infants born to women treated during pregnancy with oral erythromycin for early syphilis should be treated with an appropriate penicillin regimen. (Fachinformation zu Erythromycin, Warnhinweise)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe hypersensitivity reactions when treated with another β-lactam. (Fachinformation zu Meropenem, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Fachinformation zu Natriumphenylacetat und Natriumbenzoat, Arzneimittelwechselwirkungen)

Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Fachinformation zu Penicillamin, Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)

Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (Fachinformation zu Piperacillin und Tazobactam, Warnhinweise und Vorsichtsmaßnahmen)