Colestipol interactions

Colestipol (Colestid), a bile acid sequestrant has 83 documented interactions across the FDA labels and fact sheets we index: 2 major, 50 moderate, 31 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (2)

  • Deferasiroxiron supplementMajor

    Bile Acid Sequestrants Avoid the concomitant use of bile acid sequestrants (e.g., cholestyramine, colesevelam, colestipol) with Exjade due to a possible decrease in deferasirox concentration. (Deferasirox label, Drug interactions)

  • Raloxifeneselective estrogen receptor modulatorMajor

    EVISTA should not be co-administered with other anion exchange resins [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

Moderate interactions (50)

  • Amoxicillinpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Ampicillinpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Ampicillin and sulbactampenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • ChenodiolModerate

    Effect of Other Drugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased efficacy of CTEXLI. (Chenodiol label, Drug interactions)

  • Chlorothiazidethiazide diureticModerate

    Studies in humans show that the absorption of chlorothiazide as reflected in urinary excretion is markedly decreased even when administered one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Cholestyraminebile acid sequestrantModerate

    A study has shown that cholestyramine binds bile acids and reduces mycophenolic acid exposure. (Colestipol label, Drug interactions)

  • Colesevelambile acid sequestrantModerate

    Hypertriglyceridemia and Pancreatitis Colesevelam hydrochloride, like other bile acid sequestrants, can increase serum TG concentrations. (Colesevelam label, Warnings and precautions)

  • Demeclocyclinetetracycline antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Desogestrel and ethinyl estradioloral contraceptiveModerate

    Colesevelam: Colesevelam, a bile acid sequestrant, given together with a combination oral hormonal contraceptive, has been shown to significantly decrease the AUC of EE. (Desogestrel and ethinyl estradiol label, Drug interactions)

  • Dicloxacillinpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Digoxindigitalis glycosideModerate

    Particular caution should be observed with digitalis preparations since there are conflicting results for the effect of colestipol hydrochloride on the availability of digoxin and digitoxin. (Colestipol label, Drug interactions)

  • Doxycyclinetetracycline antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • EzetimibeModerate

    Bile Acid Sequestrants Clinical Impact: Concomitant cholestyramine administration decreased the mean exposure of total ezetimibe. (Ezetimibe label, Drug interactions)

  • Table 3: Drug Interactions that Decrease the Efficacy of VYTORIN Bile Acid Sequestrants Clinical Impact: Concomitant cholestyramine administration decreased the mean exposure of total ezetimibe approximately 55%. (Ezetimibe and simvastatin label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Furosemideloop diureticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • GemfibrozilfibrateModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Liothyroninethyroid hormoneModerate

    Drug or Drug Class Effect Bile Acid Sequestrants -Colesevelam -Cholestyramine -Colestipol Ion Exchange Resins -Kayexalate -Sevelamer Bile acid sequestrants and ion exchange resins are known to decrease thyroid hormones absorption. (Liothyronine label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • LomitapideModerate

    Bile Acid Sequestrants: Separate JUXTAPID dosing by at least 4 hours ( 7.6 ). (Lomitapide label, Drug interactions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Minocyclinetetracycline antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • MycophenolateimmunosuppressantModerate

    As colestipol also binds bile acids, colestipol may reduce mycophenolic acid exposure and potentially reduce efficacy of mycophenolate mofetil. (Colestipol label, Drug interactions)

  • Nafcillinpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveModerate

    Colesevelam: Colesevelam, a bile acid sequestrant, given together with a COC, has been shown to significantly decrease the AUC of EE. (Norgestimate and ethinyl estradiol label, Drug interactions)

  • Norgestrel and ethinyl estradioloral contraceptiveModerate

    Colesevelam Colesevelam, a bile acid sequestrant, given together with a COC, has been shown to significantly decrease the AUC of EE. (Norgestrel and ethinyl estradiol label, Drug interactions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Oxacillinpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Penicillin Gpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Penicillin Vpenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Piperacillin and tazobactampenicillin antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • PravastatinstatinModerate

    • Bile Acid Sequestrants: in patients taking a bile acid sequestrant, administer pravastatin sodium at least 1 hour before or at least 4 hours after the bile acid sequestrant () 7.1 Drug Interactions that Increase the Risk of Myopathy and Rhabdomyolysis with Pravastatin Sodium Pravastatin sodium is a substrate of the transport protein OATP1B1. (Pravastatin label, Drug interactions)

  • Propranololbeta blockerModerate

    Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption. (Colestipol label, Drug interactions)

  • The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Tetracyclinetetracycline antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Tigecyclinetetracycline antibioticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

Minor mentions (31)

  • Acebutololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • AspirinNSAIDMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Aspirin and dipyridamoleantiplatelet agentMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Atenololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Betaxololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Bisoprololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Brimonidine and timololalpha-adrenergic agonistMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Carvedilolbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • ClindamycinantibioticMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Esmololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • FenofibratefibrateMinor

    Bile-Acid Binding Resins Clinical Impact: Bile-acid binding resins may bind other drugs given concurrently. (Fenofibrate label, Drug interactions)

  • Fenofibric acidfibrateMinor

    Bile-Acid Binding Resins Clinical Impact: Bile-acid binding resins may bind other drugs given concurrently. (Fenofibric acid label, Drug interactions)

  • HydrocortisonecorticosteroidMinor

    Bile acid binding resins may also interfere with the absorption of oral phosphate supplements and hydrocortisone. (Colestipol label, Drug interactions)

  • Labetalolbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Levothyroxine and liothyroninethyroid hormoneMinor

    Cholestyramine or Colestipol - Cholestyramine or colestipol binds both T 4 and T 3 in the intestine, thus impairing absorption of these thyroid hormones. (Levothyroxine and liothyronine label, Drug interactions)

  • MethyldopaantihypertensiveMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Metoprololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Nadololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Nebivololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • NiacinMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • PhenytoinanticonvulsantMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

  • Pindololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Sotalolbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Timololbeta blockerMinor

    Effects on the absorption of other beta-blockers have not been determined. (Colestipol label, Drug interactions)

  • Bile Acid Sequestering Agents Bile acid sequestering agents such as cholestyramine and colestipol may interfere with the action of URSO 250 and URSO Forte by reducing its absorption. (Ursodiol label, Drug interactions)

  • WarfarinanticoagulantMinor

    No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin. (Colestipol label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.