Demeclocycline interactions

Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated (see WARNINGS: Pseudotumor Cerebri ). (Acitretin label, Contraindications)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

CONTRAINDICATIONS This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any of the components of the product formulation. (Demeclocycline label, Contraindications)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (Isotretinoin label, Warnings and precautions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

CONTRAINDICATIONS This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any of the components of the product formulation. (Demeclocycline label, Contraindications)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

• Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering. (Atovaquone label, Drug interactions)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

Calcium acetate capsules may decrease the bioavailability of tetracyclines or fluoroquinolones via this mechanism. (Calcium acetate label, Drug interactions)

Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

…antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Glimepiride label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Iron binds these drugs in the gut and reduces their absorption; separate the doses. (NIH Office of Dietary Supplements, Iron)

Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (Lanthanum label, Drug interactions)

Caution should be exercised when JUXTAPID is used with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen. (Lomitapide label, Warnings and precautions)

Magnesium-containing supplements and antacids reduce absorption of these drugs; separate the doses by at least two hours. (NIH Office of Dietary Supplements, Magnesium)

…antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Pioglitazone and glimepiride label, Drug interactions)

Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (Quinapril label, Drug interactions)

Although tetracycline may be concomitantly administered with quinine sulfate, patients should be monitored closely for adverse reactions associated with quinine sulfate. (Quinine label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Antibiotics Drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as Rocuronium Bromide Injection include certain antibiotics (e.g., aminoglycosides; vancomycin; tetracyclines; bacitracin; polymyxins; colistin; and sodium colistimethate). (Rocuronium label, Drug interactions)

Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (Sucralfate label, Drug interactions)

The concomitant use of other products (e.g., tetracyclines) that can cause intracranial hypertension may increase the risk. (Tretinoin label, Warnings and precautions)

Drugs Suspected of Causing Diabetes Insipidus Use with drugs suspected of causing diabetes insipidus (e.g., demeclocycline, lithium, foscarnet, clozapine) may decrease the pressor effect in addition to the antidiuretic effect of Vasostrict ® . (Vasopressin label, Drug interactions)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Demeclocycline label, Drug interactions)

Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

WARNINGS DEMECLOCYCLINE HYDROCHLORIDE, LIKE OTHER TETRACYCLINE-CLASS ANTIBIOTICS, CAN CAUSE FETAL HARM WHEN ADMINISTERED TO A PREGNANT WOMAN. (Demeclocycline label, Warnings)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

WARNINGS DEMECLOCYCLINE HYDROCHLORIDE, LIKE OTHER TETRACYCLINE-CLASS ANTIBIOTICS, CAN CAUSE FETAL HARM WHEN ADMINISTERED TO A PREGNANT WOMAN. (Demeclocycline label, Warnings)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. (Demeclocycline label, Drug interactions)

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and by iron-containing preparations. (Demeclocycline label, Drug interactions)

WARNINGS DEMECLOCYCLINE HYDROCHLORIDE, LIKE OTHER TETRACYCLINE-CLASS ANTIBIOTICS, CAN CAUSE FETAL HARM WHEN ADMINISTERED TO A PREGNANT WOMAN. (Demeclocycline label, Warnings)

The following antibiotics have been associated with various degrees of paralysis: aminoglycosides (such as neomycin, streptomycin, kanamycin, gentamicin, and dihydrostreptomycin); tetracyclines; bacitracin; polymyxin B; colistin; and sodium colistimethate. (Vecuronium label, Precautions)

…omeprazole prednisone, prednisolone ranitidine rifabutin roxithromycin sorbitol (purgative doses do not inhibit theophylline absorption) sucralfate terbutaline, systemic terfenadine tetracycline tocainide The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific… (Aminophylline label, Drug interactions)

…additional doses of Cisatracurium Besylate Injection, and to determine whether adjustments need to be made to the dose with subsequent administration. † Examples: aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, sodium colistimethate Drug or Drug Class Clinical Implications * Succinylcholine The use of succinylcholine… (Cisatracurium label, Drug interactions)

…ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (Theophylline label, Drug interactions)