Interaction Checker

Sodium phenylacetate and sodium benzoate interactions

Sodium phenylacetate and sodium benzoate (Ammonul) has 49 documented interactions across the FDA labels and fact sheets we index: 0 major, 36 moderate, 13 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (36)

  • AspirinNSAIDModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • Aspirin and dipyridamoleantiplatelet agentModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • Azelastine and fluticasoneantihistamineModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • BalsalazidesalicylateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • BeclomethasonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • BetamethasonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Bismuth subsalicylatesalicylateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • BudesonidecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Budesonide and formoterolcorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Butalbital, aspirin, and caffeinebarbiturateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • Butalbital, aspirin, caffeine, and codeinebarbiturateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • CiclesonidecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • ClobetasolcorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • DeflazacortcorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • DesonidecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • DexamethasonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • DiflunisalNSAIDModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • FludrocortisonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • FlunisolidecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • FluocinonidecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • FluticasonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Fluticasone and salmeterolcorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Glycerol phenylbutyrateModerate

    In a study of adult cancer patients, subjects received sodium phenylacetate administered as a 1-hour infusion twice daily at two dose levels of 125 and 150 mg/kg for a 2-week period. (Glycerol phenylbutyrate label, Warnings and precautions)

  • HalobetasolcorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • HydrocortisonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Menthol and methyl salicylatesalicylateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • MesalaminesalicylateModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • MethylprednisolonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • MometasonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Olopatadine and mometasoneantihistamineModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Orphenadrine, aspirin, and caffeinemuscle relaxantModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • PrednisolonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • PrednisonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • SalsalateNSAIDModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • SulfasalazinesulfonamideModerate

    Hyperventilation and Metabolic Acidosis: Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. (Sodium phenylacetate and sodium benzoate label, Warnings and precautions)

  • TriamcinolonecorticosteroidModerate

    Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

Minor mentions (13)

  • Amoxicillinpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Ampicillinpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Ampicillin and sulbactampenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Dicloxacillinpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Nafcillinpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Oxacillinpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Penicillin Gpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Penicillin Vpenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Piperacillin and tazobactampenicillin antibioticMinor

    Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • ProbenecidMinor

    Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Probenecid and colchicineMinor

    Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Valproic acidanticonvulsantMinor

    There have been reports that valproic acid can induce hyperammonemia through inhibition of the synthesis of N-acetylglutamate, a co-factor for carbamyl phosphate synthetase. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.