Interacciones de Carvedilol

Should not be used in combination with other alpha adrenergic antagonists ( 5.4 , 7.2 ) (etiqueta de Alfuzosina, Advertencias y precauciones)

Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (etiqueta de Clozapina, Advertencia en recuadro)

Do not use JALYN with other alpha-adrenergic antagonists, as this may increase the risk of hypotension. (etiqueta de Dutasterida y tamsulosina, Advertencias y precauciones)

…of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (etiqueta de Eptifibatida, Contraindicaciones)

Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication. (etiqueta de Flecainida, Advertencia en recuadro)

Avoid coadministration of FANAPT with alpha-adrenergic blocking agents and adjust medications that affect blood pressure as needed [see Warnings and Precautions (5.7) ] . (etiqueta de Iloperidona, Interacciones medicamentosas)

…that Affect Concomitant Drug Concentrations Concomitant Drug Within Class Prevention or Management Drug Interactions with TOLSURA that Increase Concomitant Drug Concentrations and May Increase Risk of Adverse Reactions Associated with the Concomitant Drug Alpha Blockers Alfuzosin Silodosin Tamsulosin Not recommended during and 2 weeks after TOLSURA treatment. (etiqueta de Itraconazol, Interacciones medicamentosas)

In addition, life-threatening arrhythmias may occur during anesthesia and surgery, and may require treatment with a beta-blocker or lidocaine. (etiqueta de Metirosina, Advertencias)

Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etiqueta de Metolazona, Advertencias)

Minoxidil should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents. (etiqueta de Minoxidil, Advertencia en recuadro)

Hypotensive Agents Do not use BYSTOLIC with other β-blockers. (etiqueta de Nebivolol, Interacciones medicamentosas)

Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (etiqueta de Protamina, Advertencia en recuadro)

Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg ( 7 ) (etiqueta de Repaglinida, Interacciones medicamentosas)

Concomitant use with metoclopramide, beta-blockers, or cholinomimetic and anticholinergic drugs is not recommended ( 7.1 , 7.2 , 7.3 ) (etiqueta de Rivastigmina, Interacciones medicamentosas)

Silodosin capsules should not be used in combination with other alpha-blockers. (etiqueta de Silodosina, Advertencias y precauciones)

…coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (etiqueta de Tadalafilo, Advertencias y precauciones)

Effect of Other Drugs on TALZENNA Effect of P-gp Inhibitors Breast Cancer Avoid coadministration of TALZENNA with the following P-gp inhibitors: itraconazole, amiodarone, carvedilol, clarithromycin, itraconazole, and verapamil. (etiqueta de Talazoparib, Interacciones medicamentosas)

• Should not be used in combination with other alpha adrenergic blocking agents ( 5.2 , 7.2 , 12.3 ) (etiqueta de Tamsulosina, Advertencias y precauciones)

…Syndrome (SS) c ] Agents with blood pressure-reducing effects Use with caution d Hypotension e Non-selective H1 receptor antagonists Contraindicated a Increased anticholinergic effects Beta-adrenergic blockers (see also agents or procedures with blood pressure-reducing effects) Use with the caution d More pronounced bradycardia, postural hypotension e Blood glucose-lowering… (etiqueta de Tranilcipromina, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Beta Blockers The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow and salt and fluid retention. (etiqueta de Ácido acetilsalicílico y dipiridamol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Intervention: During concomitant use of mefenamic acid and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Ácido mefenámico, Interacciones medicamentosas)

Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone may increase carvedilol levels resulting in further slowing of the heart rate or cardiac conduction. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). (etiqueta de Anfepramona, Interacciones medicamentosas)

Beta-blockers may decrease effectiveness. (etiqueta de Arformoterol, Interacciones medicamentosas)

Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (etiqueta de Aripiprazol, Interacciones medicamentosas)

There was also a slightly greater proportion of patients on NUVIGIL requiring new or increased use of antihypertensive medications (2.9%) compared to patients on placebo (1.8%). (etiqueta de Armodafinilo, Advertencias y precauciones)

Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etiqueta de Carvedilol, Advertencias y precauciones)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etiqueta de Asenapina, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (etiqueta de Atomoxetina, Interacciones medicamentosas)

• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (etiqueta de Avanafilo, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Amphetamines may decrease the hypotensive effect of antihypertensives. (etiqueta de Benzfetamina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (etiqueta de Bortezomib, Advertencias y precauciones)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etiqueta de Brexpiprazol, Advertencias y precauciones)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (etiqueta de Brimonidina, Interacciones medicamentosas)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

Central Nervous System (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs. (etiqueta de Bromfeniramina, pseudoefedrina y dextrometorfano, Interacciones medicamentosas)

Use caution in patients taking antihypertensive medications. (etiqueta de Bromocriptina, Advertencias y precauciones)

Beta-blockers: Use with caution. (etiqueta de Budesonida y formoterol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Risk of Hypertension and Bradycardia Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Nonselective Beta-Adrenergic Antagonists Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving nonselective beta-adrenergic antagonists may cause severe hypertension and bradycardia. (etiqueta de Bupivacaína, Advertencias y precauciones)

Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Examples: Ramipril, captopril Beta Blockers Clinical Impact: The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow, and salt and fluid retention. (etiqueta de Butalbital, ácido acetilsalicílico, cafeína y codeína, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (etiqueta de Carbidopa, Interacciones medicamentosas)

Antihypertensive drugs: May cause symptomatic postural hypotension. (etiqueta de Carbidopa y levodopa, Interacciones medicamentosas)

Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (etiqueta de Carbidopa, levodopa y entacapona, Interacciones medicamentosas)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etiqueta de Cariprazina, Advertencias y precauciones)

Intervention: • During concomitant use of VYSCOXA and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Celecoxib, Interacciones medicamentosas)

DRUG INTERACTIONS Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances. (etiqueta de Cevimelina, Interacciones medicamentosas)

…concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (etiqueta de Ciclobenzaprina, Interacciones medicamentosas)

Cyclosporine or digoxin levels may increase. (etiqueta de Carvedilol, Interacciones medicamentosas)

Cimetidine increased AUC by about 30% but caused no change in C max [see Clinical Pharmacology (12.5) ] . (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

• Antihypertensive Drugs: Monitor blood pressure. (etiqueta de Dexmetilfenidato, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Intervention: During concomitant use of ZIPSOR and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Diclofenaco, Interacciones medicamentosas)

• During concomitant use of diclofenac sodium/misoprostol and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Diclofenaco y misoprostol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Cyclosporine or digoxin levels may increase. (etiqueta de Carvedilol, Interacciones medicamentosas)

Beta Blockers Although the results of a clinical study did not indicate a safety problem associated with the administration of Dihydroergotamine Mesylate Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine. (etiqueta de Dihidroergotamina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Concomitant medications were grouped as ACE inhibitors, oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular… (etiqueta de Dofetilida, Interacciones medicamentosas)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Give a low dose of beta-blockers initially, and increase only after ECG verification of good tolerability [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] . (etiqueta de Dronedarona, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (etiqueta de Epoetina alfa, Advertencias y precauciones)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (etiqueta de Epoprostenol, Interacciones medicamentosas)

The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of ergotamine tartrate and caffeine tablets by blocking the vasodilating property of epinephrine. (etiqueta de Ergotamina y cafeína, Interacciones medicamentosas)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

Intervention: During concomitant use of FENOPROFEN CALCIUM with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects [ see Warnings and Precautions ( 5.6 ) ]. (etiqueta de Fenoprofeno, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Intervention: During concomitant use of flurbiprofen and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Flurbiprofeno, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Propranolol and Other Beta-Blockers: Coadministration of fluvoxamine maleate 100 mg per day and propranolol 160 mg per day in normal volunteers resulted in a mean five-fold increase (range 2 to 17) in minimum propranolol plasma concentrations. (etiqueta de Fluvoxamina, Interacciones medicamentosas)

• Beta-blockers may decrease effectiveness. (etiqueta de Formoterol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Table 4: Clinically Significant Drug Interaction with GVOKE and GVOKE VialDx Beta-Blockers Clincial Impact: Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given GVOKE or GVOKE VialDx. (etiqueta de Glucagón, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

During concomitant use of hydrocodone bitartrate and ibuprofen tablets and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Hidrocodona e ibuprofeno, Interacciones medicamentosas)

Intervention: During concomitant use of CALDOLOR and ACE-inhibitors, ARBs, or beta- blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Ibuprofeno, Interacciones medicamentosas)

Intervention: During concomitant use of ibuprofen and famotidine tablet and ACE-inhibitors, ARBs, or beta- blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Ibuprofeno y famotidina, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Intervention: During concomitant use of INDOCIN and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Indometacina, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

The risk of bradycardia increases with concomitant administration of drugs that slow heart rate (e.g., digoxin, amiodarone, beta-blockers). (etiqueta de Ivabradina, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Alpha Blockers tamsulosin Analgesics methadone alfentanil, buprenorphine IV and sublingual, fentanyl, oxycodone, sufentanil Methadone: The potential increase in plasma concentrations of methadone when coadministered with ketoconazole tablets may increase the risk of serious cardiovascular events including QT prolongation and torsade de pointes, or respiratory… (etiqueta de Ketoconazol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

VIMPAT should also be used with caution in patients on concomitant medications that affect cardiac conduction, including sodium channel blockers, beta-blockers, calcium channel blockers, potassium channel blockers, and medications that prolong the PR interval [see Drug Interactions (7.2) ] . (etiqueta de Lacosamida, Advertencias y precauciones)

Bradycardia-Inducing Drugs (e.g., beta-blockers) : Lanreotide Injection may decrease heart rate. (etiqueta de Lanreotida, Interacciones medicamentosas)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease, may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (etiqueta de Ledipasvir y sofosbuvir, Advertencias y precauciones)

In this setting, cardioselective beta-blockers should be considered, although they should be administered with caution. (etiqueta de Levosalbutamol, Interacciones medicamentosas)

Drug or Drug Class Effect Beta-adrenergic antagonists e.g., Propranolol > 160 mg/day) In patients treated with large doses of propranolol (> 160 mg/day), T 3 and T 4 levels change slightly, TSH levels remain normal, and patients are clinically euthyroid. (etiqueta de Levotiroxina, Interacciones medicamentosas)

Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

Drug or Drug Class Effect Beta-adrenergic antagonists (e.g., Propranolol >160 mg/day) In patients treated with large doses of propranolol (>160 mg/day), T3 and T4 levels change, TSH levels remain normal, and patients are clinically euthyroid. (etiqueta de Liotironina, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etiqueta de Lumateperona, Advertencias y precauciones)

Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (etiqueta de Lurasidona, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

There is one report of cardiopulmonary arrest, with full recovery, in a patient who was taking a beta blocker (propranolol) (see PRECAUTIONS, Cardiac Effects ). (etiqueta de Mefloquina, Interacciones medicamentosas)

Intervention: During concomitant use of QAMZOVA and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Meloxicam, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Beta-blockers Caution should be exercised when methylergonovine maleate is used concurrently with beta-blockers. (etiqueta de Metilergometrina, Interacciones medicamentosas)

Antihypertensive Drugs: Monitor blood pressure. (etiqueta de Metilfenidato, Interacciones medicamentosas)

…(oral): Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. β-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (etiqueta de Metimazol, Interacciones medicamentosas)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

REMERON/REMERONSolTab should be used with caution in patients with known cardiovascular or cerebrovascular disease that could be exacerbated by hypotension (history of myocardial infarction, angina, or ischemic stroke) and conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medication). (etiqueta de Mirtazapina, Advertencias y precauciones)

However, a retrospective analysis of the use of antihypertensive medication in these studies showed that a greater proportion of patients on PROVIGIL required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). (etiqueta de Modafinilo, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Patients receiving concomitant negative chronotropic drugs (e.g., beta blockers) may be more at risk for hypotension in case of hypersensitivity reaction. (etiqueta de Motixafortida, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

( 5.3 Hepatotoxicity) Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. (etiqueta de Naproxeno, Advertencias y precauciones)

Intervention : • During concomitant use of naproxen and esomeprazole magnesium delayed-release tablets and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Naproxeno y esomeprazol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (etiqueta de Niacina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Antihypertensives: Possible additive hypotensive effects. (etiqueta de Nitroglicerina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Dosage adjustments of concomitantly used drugs that have bradycardia effects (i.e. beta-blockers) may be necessary [see Drug Interactions (‎7.2) ]. (etiqueta de Octreotida, Advertencias y precauciones)

…of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (etiqueta de Olanzapina, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Intervention: During concomitant use of OXAPROZIN CAPSULES and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. (etiqueta de Oxaprozina, Interacciones medicamentosas)

Caution in using drugs such as beta-blockers, anti-hypertensives, and/or cardiac glycosides is advised. (etiqueta de Oximetazolina, Interacciones medicamentosas)

Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (etiqueta de Paliperidona, Advertencias y precauciones)

• Hypertension : Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. (etiqueta de Paracetamol e ibuprofeno, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Adjustments in the dose of drugs known to slow the heart rate (e.g., beta-blockers, calcium channel blockers) and correction of electrolyte disturbances may be necessary when initiating or during the course of SIGNIFOR LAR treatment. (etiqueta de Pasireotida, Advertencias y precauciones)

Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (etiqueta de Pazopanib, Advertencias y precauciones)

Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (etiqueta de Pentoxifilina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Drug Interactions Pilocarpine should be administered with caution to patients taking beta-adrenergic antagonists because of the possibility of conduction disturbances. (etiqueta de Pilocarpina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Use with caution in persons with increased risk of anticholinergic reactions, such as persons with bronchial asthma, chronic obstructive pulmonary disease, bradycardia, cardiac arrhythmias, beta blocker treatment (increased risk of anticholinergic reactions). (etiqueta de Piridostigmina, Advertencias y precauciones)

Monitor patients to assure diuretic efficacy including antihypertensive effects (7) (etiqueta de Piroxicam, Interacciones medicamentosas)

Experience with PONVORY is limited in patients receiving concurrent therapy with drugs that decrease heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers - diltiazem and verapamil, and other drugs that may decrease heart rate such as digoxin). (etiqueta de Ponesimod, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Beta-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (etiqueta de Propiltiouracilo, Interacciones medicamentosas)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (etiqueta de Quetiapina, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP P450 2D6 enzyme inhibitors may increase and rifampin may decrease carvedilol levels. (etiqueta de Carvedilol, Interacciones medicamentosas)

…Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics… (etiqueta de Rifapentina, Interacciones medicamentosas)

Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (etiqueta de Riociguat, Advertencias y precauciones)

Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (etiqueta de Risperidona, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Patients on beta-blockers may not manifest changes in heart rate, but blood pressure monitoring can detect a rise in systolic blood pressure. (etiqueta de Ropivacaína, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Beta-blockers: Use with caution. (etiqueta de Salbutamol, Interacciones medicamentosas)

• Beta-blockers: Use with caution. (etiqueta de Salmeterol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Anesthesia If treatment with COREG is to be continued perioperatively, particular care should be taken when anesthetic agents that depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used [see Overdosage (10) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (etiqueta de Sildenafilo, Advertencias y precauciones)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (etiqueta de Sofosbuvir y velpatasvir, Advertencias y precauciones)

Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (etiqueta de Sorafenib, Advertencias y precauciones)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Monitor patients to assure diuretic efficacy including antihypertensive effects. (etiqueta de Sumatriptán y naproxeno, Interacciones medicamentosas)

Initiate and/or adjust antihypertensive therapy as appropriate. (etiqueta de Sunitinib, Advertencias y precauciones)

• Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (etiqueta de Tacrolimus, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution. (etiqueta de Terbutalina, Precauciones)

In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (etiqueta de Testosterona, Advertencias y precauciones)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. (etiqueta de Carvedilol, Interacciones medicamentosas)

Insulin and oral hypoglycemics action may be enhanced. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (etiqueta de Trazodona, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Use of BCRP and/or P-gp only inhibitors (e.g., quinidine, carvedilol, eltrombopag, curcumin) may increase the exposure of ubrogepant [ s ee Clinical Pharmacology ( 12.3 ) ] . (etiqueta de Ubrogepant, Interacciones medicamentosas)

• Beta-blockers: Use with caution. (etiqueta de Umeclidinio y vilanterol, Interacciones medicamentosas)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etiqueta de Carvedilol, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etiqueta de Carvedilol, Advertencias y precauciones)

Alpha-Blockers : Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. (etiqueta de Vardenafilo, Advertencias y precauciones)

Metoprolol: Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels. (etiqueta de Venlafaxina, Interacciones medicamentosas)

COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. (etiqueta de Carvedilol, Advertencias y precauciones)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P- glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology (12.5) ]. (etiqueta de Carvedilol, Interacciones medicamentosas)

Zileuton increases propranolol levels and beta-blocker activity. (etiqueta de Zileutón, Interacciones medicamentosas)

Ziprasidone should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (etiqueta de Ziprasidona, Advertencias y precauciones)

Effects of Adenosine on Other Drugs Adenosine injection has been given with other cardioactive drugs (such as beta adrenergic blocking agents, cardiac glycosides, and calcium channel blockers) without apparent adverse interactions, but its effectiveness with these agents has not been systematically evaluated. (etiqueta de Adenosina, Interacciones medicamentosas)

In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive drugs. (etiqueta de Butorfanol, Advertencias)

CNS depressants include: alcohol, opioid analgesics, benzodiazepines, tricyclic antidepressants, sedative/hypnotics, anticonvulsants, antipsychotics, antihistamines, anticholinergics, alpha and beta blockers, general anesthetics, muscle relaxants, and illicit CNS depressants. (etiqueta de Carbamazepina, Interacciones medicamentosas)

Chlorpromazine may counteract the antihypertensive effect of guanethidine and related compounds. (etiqueta de Clorpromazina, Advertencias)

Effects on the absorption of other beta-blockers have not been determined. (etiqueta de Colestipol, Interacciones medicamentosas)

This drug is capable of blocking the antihypertensive effect of guanethidine and similarly acting compounds. (etiqueta de Desipramina, Advertencias)

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (etiqueta de Desogestrel y etinilestradiol, Advertencias)

Antihypertensives Amphetamines may antagonize the hypotensive effects of antihypertensives. (etiqueta de Dexanfetamina, Interacciones medicamentosas)

Drug Interactions ACE-inhibitors and Angiotensin II Anagonists Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors and angiotensin II antagonists. (etiqueta de Diflunisal, Interacciones medicamentosas)

Examples: α-adrenergic antagonists, β-adrenergic receptor antagonists, reserpine, quinidine, mephentermine Other Drug Interactions G u anethidine C linical Impact: Ephedrine may inhibit the neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. (etiqueta de Efedrina, Interacciones medicamentosas)

Drug Interactions ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. (etiqueta de Etodolaco, Interacciones medicamentosas)

Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (etiqueta de Fentolamina, Advertencias y precauciones)

…PROSCAR was concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines,… (etiqueta de Finasterida, Interacciones medicamentosas)

Drugs That Slow Heart Rate or Atrioventricular Conduction (e.g., beta blockers or diltiazem) Experience with GILENYA in patients receiving concurrent therapy with drugs that slow the heart rate or AV conduction (e.g., beta blockers, digoxin, or heart rate-slowing calcium channel blockers, such as diltiazem or verapamil) is limited. (etiqueta de Fingolimod, Interacciones medicamentosas)

ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (etiqueta de Icatibant, Interacciones medicamentosas)

ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. (etiqueta de Ketoprofeno, Advertencias y precauciones)

Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors and/or angiotensin II receptor antagonists. (etiqueta de Ketorolaco, Interacciones medicamentosas)

Abrupt withdrawal of β-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm. (etiqueta de Carvedilol, Advertencias y precauciones)

In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (etiqueta de Mexiletina, Interacciones medicamentosas)

Alpha-adrenergic blocking agents, such as prazosin, terazosin, and doxazosin, can antagonize the effects of midodrine hydrochloride. (etiqueta de Midodrina, Interacciones medicamentosas)

Drug Interactions: ACE-inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. (etiqueta de Nabumetona, Interacciones medicamentosas)

The antihypertensive action of guanethidine and similar agents may be blocked. (etiqueta de Nortriptilina, Advertencias)

Drug Interactions Metabolism of a number of medications, including antipsychotics, antidepressants, β-blockers, and antiarrhythmics, occurs through the cytochrome P450 2D6 isoenzyme (debrisoquine hydroxylase). (etiqueta de Perfenazina, Interacciones medicamentosas)

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concomitantly. (etiqueta de Proclorperazina, Precauciones)

Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (etiqueta de Protriptilina, Advertencias)

DRUG INTERACTIONS ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. (etiqueta de Salsalato, Interacciones medicamentosas)

Drug Interactions ACE-Inhibitors and Angiotensin II Antagonists Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors and angiotensin II antagonists. (etiqueta de Sulindaco, Interacciones medicamentosas)

Abrupt withdrawal of β-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm. (etiqueta de Carvedilol, Advertencias y precauciones)

DRUG INTERACTIONS ACE Inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE Inhibitors. (etiqueta de Tolmetina, Interacciones medicamentosas)

Angiotensin Receptor Blockers, Angiotensin Converting Enzyme Inhibitors and Potassium Sparing Diuretics Although specific interaction studies were not performed, in clinical studies, tolvaptan was used concomitantly with beta-blockers, angiotensin receptor blockers, angiotensin converting enzyme inhibitors and potassium sparing diuretics. (etiqueta de Tolvaptán, Interacciones medicamentosas)

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concurrently. (etiqueta de Trifluoperazina, Precauciones)

Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (etiqueta de Dutasterida, Interacciones medicamentosas)

Beta-adrenergic blocking agents: Coadministration of beta-adrenergic blocking agents did not have any effect on either the safety or efficacy of ibutilide in the clinical trials. (etiqueta de Ibutilida, Interacciones medicamentosas)