ब्यूटाल्बिटल, एस्पिरिन और कैफीन और प्रोबेनेसिड और कोल्चिसिन का इंटरैक्शन

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid.

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.

The biphasic action of salicylates in the renal tubules accounts for the so-called “paradoxical effect” of uricosuric agents.

The use of salicylates antagonizes the uricosuric action of probenecid (see WARNINGS ).

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma.

Butalbital, Aspirin, and Caffeine Capsules may diminish the effects of: Uricosuric agents such as probenecid and sulfinpyrazone, reducing their effectiveness in the treatment of gout.