प्रोबेनेसिड और कोल्चिसिन के इंटरैक्शन

Co-administration with colchicine, fesoterodine and solifenacin is contraindicated in subjects with varying degrees of renal or hepatic impairment. (इट्राकोनाज़ोल लेबल, बॉक्स्ड चेतावनी)

Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN. (इमिपेनेम और सिलास्टैटिन लेबल, दवाओं के इंटरैक्शन)

Antigout: colchicine ↑ colchicine The coadministration of REYATAZ with colchicine in patients with renal or hepatic impairment is not recommended. (एटाज़ानाविर लेबल, दवाओं के इंटरैक्शन)

Co-administration with probenecid is not recommended. (एमोक्सिसिलिन और क्लैवुलैनेट लेबल, दवाओं के इंटरैक्शन)

Co-administration with probenecid inhibits the renal excretion of ertapenem and is therefore not recommended. (एर्टापेनेम लेबल, दवाओं के इंटरैक्शन)

Anti-gout: colchicine ↑ colchicine GENVOYA is not recommended to be coadministered with colchicine to patients with renal or hepatic impairment. (एल्विटेग्राविर, कोबिसिस्टैट, एमट्रिसिटाबिन और टेनोफोविर लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

…contraindicated with ketoconazole tablets: methadone, disopyramide, dronedarone, ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine, methylergometrine, irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine (see PRECAUTIONS: Drug Interactions ). (कीटोकोनाज़ोल लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Therefore, the combination of ketoprofen and probenecid is not recommended. (कीटोप्रोफेन लेबल, चेतावनियां और सावधानियां)

The concomitant use of ketorolac tromethamine and probenecid is contraindicated. (कीटोरोलैक लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Colchicine in renal or hepatic impairment ( 4.4 ) (क्लैरिथ्रोमाइसिन लेबल, निषेध (कॉन्ट्राइंडिकेशन))

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

Alpha 1-adrenoreceptor antagonist: alfuzosin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine Herbal product: St. (डारुनाविर लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Alpha 1-adrenoreceptor antagonist: alfuzosin Anticonvulsants: carbamazepine, phenobarbital, phenytoin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine… (डारुनाविर और कोबिसिस्टैट लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Effect of Other Drugs on FERRIPROX UDP-Glucuronosyltransferases (UGT) Avoid use of UGT1A6 inhibitors (e.g., diclofenac, probenecid, or silymarin (milk thistle)) with FERRIPROX [ see Dosage and Administration ( 2.2 ) , Adverse Reactions ( 6.1 ), Clinical Pharmacology ( 12.3 ) ] . (डेफेरिप्रोन लेबल, दवाओं के इंटरैक्शन)

…Interactions (7.3) ] : • Alpha 1-adrenoreceptor antagonist: alfuzosin • Antianginal: ranolazine • Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine • Anti-gout: colchicine (in patients with renal and/or hepatic impairment [see Table 2 , Drug Interactions (7.3)] ) • Antipsychotics: lurasidone, pimozide • Benign prostatic hyperplasia agents:… (निर्माट्रेल्विर और रिटोनाविर लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection and Sodium Chloride Injection unless the benefit outweighs the risk. (पाइपेरासिलिन और टैज़ोबैक्टम लेबल, दवाओं के इंटरैक्शन)

Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs. (प्रालाट्रेक्सेट लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

Thus, probenecid should not be administered concurrently with bumetanide. (बुमेटेनाइड लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

Co-administration of Meropenem for injection with probenecid inhibits renal excretion of meropenem and is therefore not recommended ( 7.1 ) (मेरोपेनेम लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

…Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors:… (रिटोनाविर लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Alpha 1- Adrenoreceptor Antagonist: alfuzosin Antianginal: ranolazine Antiarrhythmic: dronedarone Anti-gout: colchicine Antipsychotics: lurasidone, pimozide Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine GI Motility Agent: cisapride Hepatitis C direct acting antiviral: elbasvir/grazoprevir HMG-CoA Reductase Inhibitors: lovastatin, simvastatin… (लोपिनाविर और रिटोनाविर लेबल, निषेध (कॉन्ट्राइंडिकेशन))

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

TO REDUCE POSSIBLE NEPHROTOXICITY, INTRAVENOUS PREHYDRATION WITH NORMAL SALINE AND ADMINISTRATION OF PROBENECID MUST BE USED WITH EACH CIDOFOVIR INFUSION. (सिडोफोविर लेबल, बॉक्स्ड चेतावनी)

Co-administration of probenecid with Cefazolin for Injection is not recommended. (सेफाज़ोलिन लेबल, दवाओं के इंटरैक्शन)

Co-administration of probenecid with cephalexin for oral suspension is not recommended. (सेफैलेक्सिन लेबल, दवाओं के इंटरैक्शन)

Administration of cefotaxime in excess of 6 grams/day should be avoided in patients receiving probenecid (see CLINICAL PHARMACOLOGY, Drug Interactions ). (सेफोटैक्सिम लेबल, दवाओं के इंटरैक्शन)

Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (सेफ्यूरोक्सिम लेबल, दवाओं के इंटरैक्शन)

Probenecid Clinical Impact: When indomethacin is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. (इंडोमेथासिन लेबल, दवाओं के इंटरैक्शन)

Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised. (एज़िथ्रोमाइसिन लेबल, दवाओं के इंटरैक्शन)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (एज़ेटिमाइब और सिमवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (>1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (एटोरवास्टेटिन लेबल, चेतावनियां और सावधानियां)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (> 1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (एम्लोडिपिन और एटोरवास्टेटिन लेबल, चेतावनियां और सावधानियां)

These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; and hypotension with calcium channel blockers metabolized by CYP3A4 (for example, verapamil, amlodipine, diltiazem) (see PRECAUTIONS, Drug Interactions ). (एरिथ्रोमाइसिन लेबल, चेतावनियां)

In order to prevent gout flares when treatment with allopurinol tablets is initiated, concurrent prophylactic treatment with colchicine or an anti-inflammatory agent is recommended [ see Dosage and Administration (2.2) ]. (एलोप्यूरिनॉल लेबल, चेतावनियां और सावधानियां)

Drug Interactions Coadministration of probenecid with intravenous acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve. (एसाइक्लोविर लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Monitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )] . (कैबोज़ैंटिनिब लेबल, दवाओं के इंटरैक्शन)

Probenecid ↑Ganciclovir Ganciclovir for Injection dose may need to be reduced. (गैनसिक्लोविर लेबल, दवाओं के इंटरैक्शन)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

(G) Colchicine Myopathy, including rhabdomyolysis, has been reported with chronic administration of colchicine at therapeutic doses. (जेमफाइब्रोज़िल लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Organic Anion Drugs Coadministration of organic anion drugs (e.g., probenecid) that undergo significant renal tubular secretion have the potential to reduce secretion of torsemide into the proximal tubule and thereby decreases the diuretic activity of torsemide. (टॉरसेमाइड लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (नेप्रोक्सेन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

The following drugs when used concomitantly with LIVALO may also increase the risk of myopathy and rhabdomyolysis: lipid-modifying dosages of niacin (>1grams/day), fibrates, and colchicine [see Drug Interactions (7) ]. (पिटावास्टेटिन लेबल, चेतावनियां और सावधानियां)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

The following drugs when used concomitantly with pravastatin sodium may also increase the risk of myopathy and rhabdomyolysis: niacin, fibrates, and colchicine [see Drug Interactions ( 7 )]. (प्रवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Consider whether the benefit of using colchicine concomitantly with fenofibric acid delayed-release capsules outweighs the increased risk of myopathy [see Drug Interactions (7) ] . (फेनोफाइब्रिक एसिड लेबल, चेतावनियां और सावधानियां)

Consider whether the benefit of using colchicine concomitantly with fenofibrate outweighs the increased risk of myopathy [see Drug Interactions (7) ]. (फेनोफाइब्रेट लेबल, चेतावनियां और सावधानियां)

In order to prevent gout flares when ULORIC is initiated, concurrent prophylactic treatment with an NSAID or colchicine is recommended [see Dosage and Administration (2.4) ]. (फेबुक्सोस्टैट लेबल, चेतावनियां और सावधानियां)

Probenecid: May increase penciclovir levels. (फैमसिक्लोविर लेबल, दवाओं के इंटरैक्शन)

Fosamprenavir calcium/ritonavir and coadministration of colchicine: Treatment of gout flares: 0.6 mg (1 tablet) x 1 dose, followed by 0.3 mg (half tablet) 1 hour later. (फोसएम्प्रेनाविर लेबल, दवाओं के इंटरैक्शन)

When used concomitantly with fluvastatin sodium extended-release tablets, lipid modifying doses (≥ 1 g/day) of niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1 )] . (फ्लुवास्टेटिन लेबल, चेतावनियां और सावधानियां)

In patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) the recommended dosage should be reduced. (बैरिसिटिनिब लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (ब्रोमोक्रिप्टिन लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid increases plasma concentrations of methotrexate in both animals and humans. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of rifampin toxicities. (रिफैम्पिसिन लेबल, दवाओं के इंटरैक्शन)

Niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1) ]. (रोसुवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Renal clearance of ucb L057 in the presence of probenecid decreased 60%, probably related to competitive inhibition of tubular secretion of ucb L057. (लेवेटिरासेटम लेबल, दवाओं के इंटरैक्शन)

However, these changes do not warrant dosage adjustment for Levofloxacin in 5% Dextrose Injection when probenecid or cimetidine is co-administered. (लेवोफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

Coadministration of lomitapide with P-gp substrates (such as aliskiren, ambrisentan, colchicine, dabigatran etexilate, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan) may increase the absorption of P-gp substrates. (लोमिटापाइड लेबल, दवाओं के इंटरैक्शन)

Colchicine: Cases of myopathy, including rhabdomyolysis, have been reported with lovastatin coadministered with colchicine, and caution should be exercised when prescribing lovastatin with colchicine (see PRECAUTIONS , Drug Interactions ). (लोवास्टेटिन लेबल, चेतावनियां)

Didanosine ↔ Ganciclovir ↑ Didanosine Patients should be closely monitored for didanosine toxicity (e.g., pancreatitis) Probenecid ↑ Ganciclovir Valganciclovir hydrochloride dose may need to be reduced. (वैलगैनसिक्लोविर लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

…Immunosuppressives Other Drugs ciprofloxacin melphalan amphotericin B azapropazon cimetidine tacrolimus fibric acid derivatives (e.g., bezafibrate, fenofibrate) gentamicin ketoconazole colchicine ranitidine methotrexate tobramycin diclofenac trimethoprim with sulfamethoxazole naproxen vancomycin sulindac During the concomitant use of a drug that may exhibit additive… (साइक्लोस्पोरिन लेबल, दवाओं के इंटरैक्शन)

Decrease ciprofloxacin absorption, resulting in lower serum and urine levels Probenecid Use with caution (interferes with renal tubular secretion of ciprofloxacin and increases ciprofloxacin serum levels) Potentiation of ciprofloxacin toxicity may occur. (सिप्रोफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (सिमवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (सुमाट्रिप्टान और नेप्रोक्सेन लेबल, दवाओं के इंटरैक्शन)

Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid : May inhibit renal excretion of metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine; monitor for potential neurotoxicity. (सोडियम फिनाइलब्यूटिरेट लेबल, दवाओं के इंटरैक्शन)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (प्रोबेनेसिड और कोल्चिसिन लेबल, चेतावनियां)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin, and chloramphenicol). (एंटाकैपोन लेबल, सावधानियां)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. (ओफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol). (कार्बिडोपा, लेवोडोपा और एंटाकैपोन लेबल, दवाओं के इंटरैक्शन)

Probenecid Probenecid is a blocker of renal tubular secretion. (गैबापेंटिन लेबल, दवाओं के इंटरैक्शन)

Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA. (ग्लिसरॉल फिनाइलब्यूटिरेट लेबल, दवाओं के इंटरैक्शन)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Uricosuric Drugs Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. (नाइट्रोफ्यूरैंटोइन लेबल, दवाओं के इंटरैक्शन)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

The uricosuric action of probenecid is also antagonized by pyrazinamide. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

…hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol (see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories–propoxyphene, aspirin, indomethacin,… (प्राज़ोसिन लेबल, दवाओं के इंटरैक्शन)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (प्रोबेनेसिड और कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate. (सोडियम फिनाइलएसीटेट और सोडियम बेंज़ोएट लेबल, दवाओं के इंटरैक्शन)

Probenecid does not affect renal tubular transport of gentamicin. (जेंटामाइसिन लेबल, दवाओं के इंटरैक्शन)

Examples Acyclovir, ganciclovir, probenecid, valacyclovir, valganciclovir Combination Oral Contraceptives Clinical Impact Concomitant use with mycophenolate mofetil decreased the systemic exposure to levonorgestrel, but did not affect the systemic exposure to ethinylestradiol [see Clinical Pharmacology ( 12.3 )], which may result in reduced combination oral contraceptive… (माइकोफेनोलेट लेबल, दवाओं के इंटरैक्शन)