ब्यूटाल्बिटल, एस्पिरिन, कैफीन और कोडीन और प्रोबेनेसिड का इंटरैक्शन

In patients on probenecid the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid.

In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.

The biphasic action of salicylates in the renal tubules accounts for the so-called “paradoxical effect” of uricosuric agents.

The use of salicylates antagonizes the uricosuric action of probenecid (see WARNINGS ).

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma.

Examples: Probenecid Carbonic Anhydrase Inhibitors Clinical Impact: Concurrent use with aspirin can lead to high serum concentrations of the carbonic anhydrase inhibitor and cause toxicity due to competition at the renal tubule for secretion.