सिनाकैल्सेट और कीटोकोनाज़ोल का इंटरैक्शन

Other colchicine, in subjects with renal or hepatic impairment; tolvaptan colchicine alcohol, cinacalcet Colchicine: The potential increase in plasma concentrations of colchicine when coadministered with ketoconazole tablets may increase the risk of potentially fatal adverse events Tolvaptan: Ketoconazole 200 mg administered with tolvaptan increased tolvaptan…

QT Interval Prolongation and V entricular A rr h ythmia Decreases in serum calcium can also prolong the QT interval, potentially resulting in ventricular arrhythmia.

Co-administration with a strong CYP3A4 inhibitor may increase serum levels of cinacalcet.

Dose adjustment of Sensipar may be required if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, itraconazole).

Strong CYP3A4 Inhibitors Cinacalcet is partially metabolized by CYP3A4.