एस्ट्राडियोल और डायनोजेस्ट और एटोनोजेस्ट्रेल और एथिनिल एस्ट्राडियोल का इंटरैक्शन

WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive (CHC) use.

Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive (CHC) use.

Consider an alternate contraceptive method for women with uncontrolled dyslipidemia.

In these studies, which were required or sponsored by regulatory agencies, Etonogestrel/Ethinyl Estradiol Vaginal Ring users had a risk of VTE similar to Combined Oral Contraceptives (COCs) users (see Table 1 for adjusted hazard ratios).

Table 1: Estimates (Hazard Ratios) of Venous Thromboembolism Risk in Users of Etonogestrel/Ethinyl Estradiol Vaginal Ring Compared to Users of Combined Oral Contraceptives (COCs) Epidemiologic Study (Author, Year of Publication) Population Studied Comparator Product(s) Hazard Ratios (HR) (95% CI) TASC (Dinger, 2012) Initiators, including new users, switchers…

Effects of Combined Oral Contraceptives on Other Drugs COCs containing ethinyl estradiol may inhibit the metabolism of other compounds.

Effects of Other Drugs on Combined Oral Contraceptives Substances diminishing the efficacy of COCs: Dienogest is a substrate of CYP3A4.