Estradiol and dienogest and Etonogestrel and ethinyl estradiol interaction
Estradiol and dienogest and Etonogestrel and ethinyl estradiol: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Etonogestrel and ethinyl estradiol (Etonogestrel/Ethinyl Estradiol) label · effective 2025-02-26
WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive (CHC) use.
Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive (CHC) use.
Consider an alternate contraceptive method for women with uncontrolled dyslipidemia.
In these studies, which were required or sponsored by regulatory agencies, Etonogestrel/Ethinyl Estradiol Vaginal Ring users had a risk of VTE similar to Combined Oral Contraceptives (COCs) users (see Table 1 for adjusted hazard ratios).
Table 1: Estimates (Hazard Ratios) of Venous Thromboembolism Risk in Users of Etonogestrel/Ethinyl Estradiol Vaginal Ring Compared to Users of Combined Oral Contraceptives (COCs) Epidemiologic Study (Author, Year of Publication) Population Studied Comparator Product(s) Hazard Ratios (HR) (95% CI) TASC (Dinger, 2012) Initiators, including new users, switchers…
From the Estradiol and dienogest (Natazia) label · effective 2024-06-26
Effects of Combined Oral Contraceptives on Other Drugs COCs containing ethinyl estradiol may inhibit the metabolism of other compounds.
Effects of Other Drugs on Combined Oral Contraceptives Substances diminishing the efficacy of COCs: Dienogest is a substrate of CYP3A4.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.