फ्लुकोनाज़ोल और लेम्बोरेक्सेंट का इंटरैक्शन

Avoid concomitant use of fluconazole with lemborexant.

Lemborexant Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6-and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence.

Strong or moderate CYP3A inhibitors: Avoid concomitant use.

Intervention: Avoid concomitant use of DAYVIGO with strong or moderate CYP3A inhibitors [see Dosage and Administration ( 2.2 )].

Weak CYP3A inhibitors: The maximum recommended dose is 5 mg.

Drugs Having Clinically Important Interactions with DAYVIGO Table 2: Clinically Important Drug Interactions with DAYVIGO Effect of Other Drugs on DAYVIGO Strong, Moderate, and Weak CYP3A Inhibitors Clinical Impact: Concomitant use with a strong, moderate, or weak CYP3A inhibitor increases lemborexant AUC and C max which may increase the risk of DAYVIGO adverse…

The maximum recommended dose of DAYVIGO with weak CYP3A inhibitors is 5 mg [see Dosage and Administration ( 2.2 )].