लेवोडोपा और टोलकैपोन का इंटरैक्शन

Tolcapone tablets is also contraindicated in patients with a history of nontraumatic rhabdomyolysis or hyperpyrexia and confusion possibly related to medication (see PRECAUTIONS: Events Reported With Dopaminergic Therapy ).

Falling Asleep During Activities of Daily Living and Somnolence Tolcapone increases plasma levels of levodopa in patients taking concomitant carbidopa levodopa products (see DOSAGE AND ADMINISTRATION ).

Therefore, caution should be exercised when desipramine is administered to Parkinson's disease patients being treated with Tolcapone tablets and levodopa/carbidopa.

Tolcapone enhances levodopa bioavailability and, therefore, may increase the occurrence of orthostatic hypotension.

Clinical trial data suggest that hallucinations associated with tolcapone use may be responsive to levodopa dose reduction.