Interaksi Asam etakrinat

Asam etakrinat (Edecrin), golongan diuretik loop, memiliki 364 interaksi terdokumentasi dalam label FDA dan lembar fakta yang kami indeks: 51 mayor, 248 moderat, 64 minor, dan 1 dengan label yang melaporkan tidak ada interaksi bermakna. Setiap entri di bawah ini mengutip kalimat yang mendasarinya. Halaman obat ini adalah titik awal, bukan putusan untuk situasi Anda.

Interaksi dari label

Interaksi mayor (51)

  • AmikasinaminoglikosidaMayor

    Avoid concomitant use of ARIKAYCE with ethacrynic acid, furosemide, urea, or intravenous mannitol. (label Amikasin, Interaksi obat)

  • Amiloriddiuretik hemat kaliumMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Arsen trioksidaobat yang memperpanjang interval QTMayor

    The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (label Arsen trioksida, Peringatan dan perhatian)

  • Asetazolamidpenghambat karbonat anhidraseMayor

    Like other diuretics it may precipitate hepatic coma and death. (label Asam etakrinat, Peringatan)

  • Atenolol dan klortalidonpenyekat betaMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Bumetaniddiuretik loopMayor

    Like other diuretics it may precipitate hepatic coma and death. (label Asam etakrinat, Peringatan)

  • Digoksinglikosida digitalisMayor

    These generally have fallen into two categories: (1) patients with severe myocardial disease who have been receiving digitalis and presumably developed acute hypokalemia with fatal arrhythmia; (2) patients with severely decompensated hepatic cirrhosis with ascites, with or without accompanying encephalopathy, who were in electrolyte imbalance and died because… (label Asam etakrinat, Peringatan)

  • DofetilidantiaritmiaMayor

    In the DIAMOND trials, 1252 patients were treated with dofetilide and diuretics concomitantly, of whom 493 died compared to 508 deaths among the 1248 patients receiving placebo and diuretics. (label Dofetilid, Interaksi obat)

  • Droperidolantagonis dopaminMayor

    Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (label Droperidol, Peringatan kotak hitam)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Enalaprilatpenghambat ACEMayor

    …sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (label Enalaprilat, Peringatan)

  • Eplerenonantagonis aldosteronMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • EptifibatidantiplateletMayor

    …of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (label Eptifibatid, Kontraindikasi)

  • Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (label Folitropin, Peringatan dan perhatian)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Furosemiddiuretik loopMayor

    Like other diuretics it may precipitate hepatic coma and death. (label Asam etakrinat, Peringatan)

  • GentamisinaminoglikosidaMayor

    The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (label Gentamisin, Peringatan kotak hitam)

  • Hidroklorotiaziddiuretik tiazidMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Indapamiddiuretik tiazidMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Irbesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Avoid diuretics or laxatives in patients with diarrhea. (label Irinotekan, Peringatan dan perhatian)

  • Itrakonazolantijamur azolMayor

    Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (label Itrakonazol, Interaksi obat)

  • Kalium sitratsuplemen kaliumMayor

    The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (label Kalium sitrat, Interaksi obat)

  • Kandesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Klorotiaziddiuretik tiazidMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Klortalidondiuretik tiazidMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • KlozapinantipsikotikMayor

    Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (label Klozapin, Peringatan kotak hitam)

  • Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (label Koriogonadotropin alfa, Peringatan)

  • Kuinaprilpenghambat ACEMayor

    …sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include patients with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (label Kuinapril, Peringatan)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Losartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Metolazondiuretik tiazidMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • MinoksidilvasodilatorMayor

    Minoxidil should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents. (label Minoksidil, Peringatan kotak hitam)

  • Natrium bikarbonatantasidaMayor

    Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (label Natrium bikarbonat, Kontraindikasi)

  • NeomisinaminoglikosidaMayor

    The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (label Neomisin, Peringatan kotak hitam)

  • Olmesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Olmesartan, amlodipin, dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • SiklosporinimunosupresanMayor

    Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (label Siklosporin, Interaksi obat)

  • Spironolaktonantagonis aldosteronMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Spironolakton dan hidroklorotiazidantagonis aldosteronMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Tadalafilpenghambat PDE5Mayor

    …coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (label Tadalafil, Peringatan dan perhatian)

  • Telmisartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • TobramisinaminoglikosidaMayor

    TOBI Podhaler should not be administered concomitantly with ethacrynic acid, furosemide, urea, or intravenous mannitol. (label Tobramisin, Interaksi obat)

  • Torasemiddiuretik loopMayor

    Like other diuretics it may precipitate hepatic coma and death. (label Asam etakrinat, Peringatan)

  • Triamterendiuretik hemat kaliumMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Triamteren dan hidroklorotiaziddiuretik hemat kaliumMayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

  • Valsartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Mayor

    CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (label Asam etakrinat, Kontraindikasi)

Interaksi moderat (248)

  • Alfuzosinpenyekat alfaModerat

    Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (label Alfuzosin, Peringatan dan perhatian)

  • AliskirenantihipertensiModerat

    Risk factors for the development of hyperkalemia include renal insufficiency, diabetes, combination use with ARBs or ACEIs [see Contraindications ( 4 ), Warnings and Precautions ( 5.2 ), and Clinical Studies ( 14.3 )] , NSAIDs, or potassium supplements or potassium sparing diuretics. (label Aliskiren, Peringatan dan perhatian)

  • Alogliptin dan metforminpenghambat DPP-4Moderat

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs and isoniazid Alogliptin Cytochrome (CYP) P450, CYP-Substrates or Inhibitors Clinical Impact: Insulin Secretagogues and Insulin Insulin and insulin secretagogues… (label Alogliptin dan metformin, Interaksi obat)

  • Alopurinolpenghambat xantin oksidaseModerat

    Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (label Alopurinol, Peringatan dan perhatian)

  • AmiodaronantiaritmiaModerat

    Give special attention to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or in patients receiving concomitant diuretics and laxatives. (label Amiodaron, Peringatan dan perhatian)

  • Amlodipin dan benazeprilpenghambat kanal kalsium dihidropiridinModerat

    Symptomatic hypotension is most likely to occur in patients who have heart failure, severe aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy or have been volume or salt depleted as a result of diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (label Amlodipin dan benazepril, Peringatan dan perhatian)

  • Amlodipin dan olmesartanpenghambat kanal kalsium dihidropiridinModerat

    In patients with an activated renin-angiotensin system, such as volume and/or salt-depleted patients (e.g., those being treated with high doses of diuretics) symptomatic hypotension may be anticipated after initiation of treatment with olmesartan medoxomil . (label Amlodipin dan olmesartan, Peringatan dan perhatian)

  • Amlodipin dan valsartanpenghambat kanal kalsium dihidropiridinModerat

    In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur in patients receiving angiotensin receptor blockers. (label Amlodipin dan valsartan, Peringatan dan perhatian)

  • ApiksabanantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • Arformoterolagonis beta-adrenergikModerat

    Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. (label Arformoterol, Interaksi obat)

  • ArgatrobanantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • AripiprazolantipsikotikModerat

    Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (label Aripiprazol, Interaksi obat)

  • Armodafinilstimulan SSPModerat

    There was also a slightly greater proportion of patients on NUVIGIL requiring new or increased use of antihypertensive medications (2.9%) compared to patients on placebo (1.8%). (label Armodafinil, Peringatan dan perhatian)

  • Asam mefenamatOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Asam zoledronatbisfosfonatModerat

    Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (label Asam zoledronat, Peringatan dan perhatian)

  • Asebutololpenyekat betaModerat

    Although β-blockers should be avoided in overt cardiac failure, acebutolol can be used with caution in patients with a history of heart failure who are controlled with digitalis and/or diuretics. (label Asebutolol, Peringatan)

  • AsenapinantipsikotikModerat

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (label Asenapin, Peringatan dan perhatian)

  • AspirinOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Aspirin dan dipiridamolantiplateletModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Atenololpenyekat betaModerat

    Because of its relative beta 1 selectivity, however, TENORMIN may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (label Atenolol, Peringatan)

  • Atomoksetinpenghambat ambilan kembali norepinefrinModerat

    Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (label Atomoksetin, Interaksi obat)

  • Avanafilpenghambat PDE5Moderat

    • Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (label Avanafil, Peringatan dan perhatian)

  • Azilsartanpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with azilsartan medoxomil. (label Azilsartan, Peringatan dan perhatian)

  • Beksagliflozinpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ) [see Use in Specific Populations ( 8.6 )] , elderly patients, patients with low systolic blood pressure, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Beksagliflozin, Peringatan dan perhatian)

  • Beladona dan opiumopioidModerat

    Diuretics Clinical Impact : Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Beladona dan opium, Interaksi obat)

  • Benazeprilpenghambat ACEModerat

    Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mm Hg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (label Benazepril, Peringatan dan perhatian)

  • Benzfetaminstimulan SSPModerat

    Amphetamines may decrease the hypotensive effect of antihypertensives. (label Benzfetamin, Interaksi obat)

  • Bisoprololpenyekat betaModerat

    Because of its relative beta 1 -selectivity, however, BISOPROLOL FUMARATE may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (label Bisoprolol, Peringatan)

  • BivalirudinantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • BortezomibModerat

    Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (label Bortezomib, Peringatan dan perhatian)

  • BrekspiprazolantipsikotikModerat

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (label Brekspiprazol, Peringatan dan perhatian)

  • Brimonidinagonis alfa-adrenergikModerat

    Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (label Brimonidin, Interaksi obat)

  • Brimonidin dan timololagonis alfa-adrenergikModerat

    Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (label Brimonidin dan timolol, Interaksi obat)

  • Central Nervous System (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs. (label Bromfeniramin, pseudoefedrin, dan dekstrometorfan, Interaksi obat)

  • Bromokriptinagonis dopaminModerat

    Use caution in patients taking antihypertensive medications. (label Bromokriptin, Peringatan dan perhatian)

  • Budesonid dan formoterolkortikosteroidModerat

    Diuretics: Use with caution. (label Budesonid dan formoterol, Interaksi obat)

  • BuprenorfinopioidModerat

    Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Buprenorfin, Interaksi obat)

  • Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Buprenorfin dan nalokson, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Butalbital, parasetamol, kafein, dan kodein, Interaksi obat)

  • DabigatranantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • Dapagliflozinpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ), elderly patients, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Dapagliflozin, Peringatan dan perhatian)

  • Dapagliflozin dan metforminpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ), elderly patients, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Dapagliflozin dan metformin, Peringatan dan perhatian)

  • Dekslansoprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (label Dekslansoprazol, Peringatan dan perhatian)

  • Deksmetilfenidatstimulan SSPModerat

    • Antihypertensive Drugs: Monitor blood pressure. (label Deksmetilfenidat, Interaksi obat)

  • Desipraminantidepresan trisiklikModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (label Desipramin, Peringatan)

  • …Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (label Desmopresin, Interaksi obat)

  • DesvenlafaksinSNRIModerat

    Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (label Desvenlafaksin, Peringatan dan perhatian)

  • DiazoksidModerat

    The concomitant administration of thiazides or other diuretics may potentiate the hyperglycemic and hyperuricemic effects of PROGLYCEM. (label Diazoksid, Interaksi obat)

  • Dietilpropionstimulan SSPModerat

    The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). (label Dietilpropion, Interaksi obat)

  • DiflunisalOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • DiklofenakOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Diklorfenamidpenghambat karbonat anhidraseModerat

    Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (label Diklorfenamid, Interaksi obat)

  • Dokserkalsiferolanalog vitamin DModerat

    Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (label Dokserkalsiferol, Peringatan dan perhatian)

  • Drospirenon dan etinilestradiolkontrasepsi oralModerat

    Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (label Drospirenon dan etinilestradiol, Peringatan dan perhatian)

  • DuloksetinSNRIModerat

    The risk of BP decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see Drug Interactions ( 7.1 )] and in patients taking duloxetine delayed-release capsules at doses above 60 mg daily. (label Duloksetin, Peringatan dan perhatian)

  • EdoksabanantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • Empagliflozinpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ), elderly patients, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Empagliflozin, Peringatan dan perhatian)

  • Empagliflozin dan metforminpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ), elderly patients, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Empagliflozin dan metformin, Peringatan dan perhatian)

  • Enalaprilpenghambat ACEModerat

    Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (label Enalapril, Peringatan dan perhatian)

  • EnoksaparinantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • EpinefrinsimpatomimetikModerat

    …Precautions (5.6) and Adverse Reactions (6) ]. β-blockers, such as propranolol Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane Antihistamines Thyroid hormones Diuretics Cardiac glycosides, such as digitalis glycosides Quinidine Drugs potentiating hypokalemic effects of epinephrine • Potassium depleting diuretics • Corticosteroids • Theophylline… (label Epinefrin, Interaksi obat)

  • Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (label Epoetin alfa, Peringatan dan perhatian)

  • Epoprostenolanalog prostaglandinModerat

    Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (label Epoprostenol, Interaksi obat)

  • EsitalopramSSRIModerat

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (label Esitalopram, Peringatan dan perhatian)

  • Esmololpenyekat betaModerat

    Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (label Esmolol, Interaksi obat)

  • Esomeprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (label Esomeprazol, Peringatan dan perhatian)

  • EtodolakOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Fenelzinpenghambat MAOModerat

    …hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine Phenelzine sulfate should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result. (label Fenelzin, Peringatan)

  • FenoprofenOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • FentanilopioidModerat

    …treatment with Class 1 and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval and 6) electrolyte imbalance, in particular hypokalemia and hypomagnesemia, or concomitant treatment with drugs (e.g., diuretics) that may cause electrolyte imbalance. (label Fentanil, Peringatan dan perhatian)

  • Fentermin dan topiramatstimulan SSPModerat

    In addition, when phentermine and topiramate extended-release capsules are used in conjunction with nonpotassium sparing diuretics this may further potentiate potassium-wasting. (label Fentermin dan topiramat, Peringatan dan perhatian)

  • FludrokortisonkortikosteroidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Flukonazolantijamur azolModerat

    An effect of this magnitude should not necessitate a change in the fluconazole dose regimen in subjects receiving concomitant diuretics. (label Flukonazol, Interaksi obat)

  • FluoksetinSSRIModerat

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (label Fluoksetin, Peringatan dan perhatian)

  • FlurbiprofenOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Flutikason dan salmeterolkortikosteroidModerat

    Diuretics: Use with caution. (label Flutikason dan salmeterol, Interaksi obat)

  • FluvoksaminSSRIModerat

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (label Fluvoksamin, Peringatan dan perhatian)

  • FondaparinuksantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • Formoterolagonis beta-adrenergikModerat

    • Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. (label Formoterol, Interaksi obat)

  • Fosinoprilpenghambat ACEModerat

    Symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (label Fosinopril, Peringatan)

  • FoskarnetantivirusModerat

    When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (label Foskarnet, Interaksi obat)

  • GlimepiridsulfonilureaModerat

    …danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline),… (label Glimepirid, Interaksi obat)

  • GlipizidsulfonilureaModerat

    …may reduce the glucose-lowering effect of GLUCOTROL XL, leading to worsening glycemic control: atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic… (label Glipizid, Interaksi obat)

  • HaloperidolantipsikotikModerat

    Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (label Haloperidol, Interaksi obat)

  • HeparinantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • HidrokodonopioidModerat

    Example: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Hidrokodon, Interaksi obat)

  • Diuretics : Hydrocodone may reduce the efficacy of diuretics. (label Hidrokodon dan homatropin, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Diuretics : Hydrocodone may reduce the efficacy of diuretics. (label Hidrokodon dan klorfeniramin, Interaksi obat)

  • Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Hidrokodon dan parasetamol, Interaksi obat)

  • HidromorfonopioidModerat

    Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Hidromorfon, Interaksi obat)

  • IbuprofenOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • IloperidonantipsikotikModerat

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (label Iloperidon, Peringatan dan perhatian)

  • Imipraminantidepresan trisiklikModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (label Imipramin, Peringatan)

  • IndometasinOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Insulin aspartinsulinModerat

    Drugs That May Decrease the Blood Glucose Lowering Effect of Insulin Aspart Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g.,… (label Insulin aspart, Interaksi obat)

  • Insulin degludekinsulinModerat

    Drugs That May Decrease the Blood Glucose Lowering Effect of Insulin Degludec Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g.,… (label Insulin degludek, Interaksi obat)

  • Insulin detemirinsulinModerat

    Drugs That May Decrease the Blood Glucose Lowering Effect of LEVEMIR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol,… (label Insulin detemir, Interaksi obat)

  • Insulin glargininsulinModerat

    Drugs that May Decrease the Blood Glucose Lowering Effect of Insulin Glargine-yfgn Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents… (label Insulin glargin, Interaksi obat)

  • Insulin lisproinsulinModerat

    Drugs That May Decrease the Blood Glucose Lowering Effect of LYUMJEV Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol,… (label Insulin lispro, Interaksi obat)

  • Ipratropium dan salbutamolantikolinergikModerat

    Diuretics The electrocardiogram (ECG) changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by β-agonists, especially when the recommended dose of the β-agonist is exceeded. (label Ipratropium dan salbutamol, Interaksi obat)

  • Irbesartanpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension in Volume or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initialization of treatment with AVAPRO. (label Irbesartan, Peringatan dan perhatian)

  • Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (label Kalium iodida, Interaksi obat)

  • Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (label Kalsium klorida, Interaksi obat)

  • Kanagliflozinpenghambat SGLT2Moderat

    Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m 2 ), elderly patients, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. (label Kanagliflozin, Peringatan dan perhatian)

  • Kandesartanpenghambat reseptor angiotensin II (ARB)Moderat

    Symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (label Kandesartan, Peringatan dan perhatian)

  • Kaptoprilpenghambat ACEModerat

    Hypotension Excessive hypotension was rarely seen in hypertensive patients but is a possible consequence of captopril use in salt/volume depleted persons (such as those treated vigorously with diuretics), patients with heart failure or those patients undergoing renal dialysis (see PRECAUTIONS : Drug Interactions ). (label Kaptopril, Peringatan)

  • KarbamazepinantikonvulsanModerat

    Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (label Karbamazepin, Peringatan dan perhatian)

  • KarbidopaModerat

    Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (label Karbidopa, Interaksi obat)

  • Karbidopa dan levodopaobat dopaminergikModerat

    Antihypertensive drugs: May cause symptomatic postural hypotension. (label Karbidopa dan levodopa, Interaksi obat)

  • Karbidopa, levodopa, dan entakaponobat dopaminergikModerat

    Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (label Karbidopa, levodopa, dan entakapon, Interaksi obat)

  • KariprazinantipsikotikModerat

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (label Kariprazin, Peringatan dan perhatian)

  • Karvedilolpenyekat betaModerat

    If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (label Karvedilol, Peringatan dan perhatian)

  • Ketokonazolantijamur azolModerat

    Diuretics eplerenone The potential increase in plasma concentrations of eplerenone when coadministered with ketoconazole tablets may increase the risk of hyperkalemia and hypotension. (label Ketokonazol, Interaksi obat)

  • KetoprofenOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • KetorolakOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • KlofarabinantimetabolitModerat

    Consider use of diuretics and/or albumin. (label Klofarabin, Peringatan dan perhatian)

  • KlorpromazinantipsikotikModerat

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (label Klorpromazin, Perhatian)

  • KodeinopioidModerat

    Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Kodein, Interaksi obat)

  • Kolestiraminsekuestran asam empeduModerat

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (label Kolestiramin, Interaksi obat)

  • KuetiapinantipsikotikModerat

    Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (label Kuetiapin, Peringatan dan perhatian)

  • KuinidinantiaritmiaModerat

    Drugs that alkalinize the urine ( carbonic-anhydrase inhibitors, sodium bicarbonate, thiazide diuretics ) reduce renal elimination of quinidine. (label Kuinidin, Interaksi obat)

  • Lansoprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (label Lansoprazol, Peringatan dan perhatian)

  • LevomilnasipranSNRIModerat

    Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (label Levomilnasipran, Peringatan dan perhatian)

  • LevorfanolopioidModerat

    Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Levorfanol, Interaksi obat)

  • Levosalbutamolagonis beta-adrenergikModerat

    Diuretics The ECG changes or hypokalemia that may result from the administration of non-potassium-sparing diuretics (such as loop and thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. (label Levosalbutamol, Interaksi obat)

  • LinezolidantibiotikModerat

    Monitor serum sodium levels regularly in the elderly, in patients taking diuretics, and in other patients at risk of hyponatremia and/or SIADH while taking Linezolid injection. (label Linezolid, Peringatan dan perhatian)

  • Lisinoprilpenghambat ACEModerat

    Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (label Lisinopril, Peringatan dan perhatian)

  • Litiumobat serotonergikModerat

    Lithium generally should not be given with diuretics (see PRECAUTIONS, Drug Interactions ). (label Asam etakrinat, Peringatan)

  • Losartanpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with COZAAR. (label Losartan, Peringatan dan perhatian)

  • LumateperonantipsikotikModerat

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (label Lumateperon, Peringatan dan perhatian)

  • LurasidonantipsikotikModerat

    Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (label Lurasidon, Peringatan dan perhatian)

  • MekamilaminantihipertensiModerat

    The action of Mecamylamine HCl may be potentiated by anesthesia, other antihypertensive drugs and alcohol. (label Mekamilamin, Interaksi obat)

  • MeloksikamOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • MetadonopioidModerat

    Closely monitor patients with risk factors for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia), a history of cardiac conduction abnormalities, and those taking medications affecting cardiac conduction. (label Metadon, Peringatan dan perhatian)

  • Metilfenidatstimulan SSPModerat

    Antihypertensive Drugs: Monitor blood pressure. (label Metilfenidat, Interaksi obat)

  • Metoprololpenyekat betaModerat

    If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Metoprolol Tartrate Tablets [see Dosage and Administration (2) ]. (label Metoprolol, Peringatan dan perhatian)

  • MilnasipranSNRIModerat

    Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (label Milnasipran, Peringatan dan perhatian)

  • MirtazapinantidepresanModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (label Mirtazapin, Peringatan dan perhatian)

  • Modafinilstimulan SSPModerat

    However, a retrospective analysis of the use of antihypertensive medication in these studies showed that a greater proportion of patients on PROVIGIL required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). (label Modafinil, Peringatan dan perhatian)

  • Moeksiprilpenghambat ACEModerat

    Symptomatic hypotension is most likely to occur in patients who have been salt- and volume- depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (label Moeksipril, Peringatan)

  • MorfinopioidModerat

    Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Morfin, Interaksi obat)

  • NabumetonOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Nadololpenyekat betaModerat

    Although beta-blockers should be avoided in overt congestive heart failure, if necessary, they can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (label Nadolol, Peringatan)

  • NalbufinopioidModerat

    Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Nalbufin, Interaksi obat)

  • NaproksenOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (label Natrium zirkonium siklosilikat, Peringatan dan perhatian)

  • NiasinModerat

    Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (label Niasin, Interaksi obat)

  • Nifedipinpenghambat kanal kalsium dihidropiridinModerat

    Other Diuretics, PDE5 inhibitors, alpha-methyldopa: Nifedipine may increase the blood pressure lowering effect of these concomitantly administered agents. (label Nifedipin, Interaksi obat)

  • Nimodipinpenghambat kanal kalsium dihidropiridinModerat

    Blood Pressure Lowering Drugs Nimodipine may increase the blood pressure lowering effect of concomitantly administered anti-hypertensives such as diuretics, beta-blockers, ACE inhibitors, angiotensin receptor blockers, other calcium channel blockers, α-adrenergic blockers, PDE5 inhibitors, and α-methyldopa. (label Nimodipin, Interaksi obat)

  • NitrogliserinnitratModerat

    Antihypertensives: Possible additive hypotensive effects. (label Nitrogliserin, Interaksi obat)

  • OksaprozinOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • OksikodonopioidModerat

    Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Oksikodon, Interaksi obat)

  • Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Oksikodon dan parasetamol, Interaksi obat)

  • OksimorfonopioidModerat

    Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Oksimorfon, Interaksi obat)

  • OlanzapinantipsikotikModerat

    …of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (label Olanzapin, Peringatan dan perhatian)

  • Olanzapin dan fluoksetinantipsikotikModerat

    …and fluoxetine capsules should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (label Olanzapin dan fluoksetin, Peringatan dan perhatian)

  • OliseridinopioidModerat

    Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Oliseridin, Interaksi obat)

  • Olmesartanpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin-aldosterone system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may be anticipated after initiation of treatment with Benicar. (label Olmesartan, Peringatan dan perhatian)

  • Omeprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (label Omeprazol, Peringatan dan perhatian)

  • Omeprazol dan natrium bikarbonatpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (label Omeprazol dan natrium bikarbonat, Peringatan dan perhatian)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • PaliperidonantipsikotikModerat

    Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (label Paliperidon, Peringatan dan perhatian)

  • Pantoprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (label Pantoprazol, Peringatan dan perhatian)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Parasetamol dan kodein, Interaksi obat)

  • Parikalsitolanalog vitamin DModerat

    The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (label Parikalsitol, Peringatan dan perhatian)

  • ParoksetinSSRIModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SNRIs and SSRIs. [see Use in Specific Populations ( 8.5 )]. (label Paroksetin, Peringatan dan perhatian)

  • PazopanibModerat

    Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (label Pazopanib, Peringatan dan perhatian)

  • Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Pentazosin dan nalokson, Interaksi obat)

  • PentoksifilinmetilxantinModerat

    Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (label Pentoksifilin, Interaksi obat)

  • Perindoprilpenghambat ACEModerat

    Symptomatic hypotension is most likely to occur in patients who have been volume or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea or vomiting [see Dosage and Administration (2.1) ] . (label Perindopril, Peringatan dan perhatian)

  • PetidinopioidModerat

    Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Petidin, Interaksi obat)

  • Pindololpenyekat betaModerat

    Although beta-blockers should be avoided in overt congestive heart failure, if necessary, pindolol tablets can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (label Pindolol, Peringatan)

  • Pioglitazon dan glimepiridtiazolidindionModerat

    …danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline),… (label Pioglitazon dan glimepirid, Interaksi obat)

  • PiroksikamOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • PlazomisinaminoglikosidaModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • Prazosinpenyekat alfaModerat

    Syncopal episodes have usually occurred within 30 to 90 minutes of the initial dose of the drug; occasionally, they have been reported in association with rapid dosage increases or the introduction of another antihypertensive drug into the regimen of a patient taking high doses of prazosin hydrochloride capsules. (label Prazosin, Peringatan)

  • ProklorperazinantipsikotikModerat

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (label Proklorperazin, Perhatian)

  • Diuretics : Codeine may reduce the efficacy of diuretics. (label Prometazin dan kodein, Interaksi obat)

  • Rabeprazolpenghambat pompa protonModerat

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (label Rabeprazol, Peringatan dan perhatian)

  • Ramiprilpenghambat ACEModerat

    Experience with another ACE inhibitor suggests that these increases would be reversible upon discontinuation of ramipril and/or diuretic therapy. (label Ramipril, Peringatan dan perhatian)

  • RiosiguatvasodilatorModerat

    Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (label Riosiguat, Peringatan dan perhatian)

  • RisperidonantipsikotikModerat

    Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (label Risperidon, Peringatan dan perhatian)

  • RivaroksabanantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • Sakubitril dan valsartanpenghambat reseptor angiotensin II (ARB)Moderat

    Patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), are at greater risk. (label Sakubitril dan valsartan, Peringatan dan perhatian)

  • Salbutamolagonis beta-adrenergikModerat

    Diuretics: Use with caution. (label Salbutamol, Interaksi obat)

  • Salmeterolagonis beta-adrenergikModerat

    • Diuretics: Use with caution. (label Salmeterol, Interaksi obat)

  • SalsalatOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • SefadroksilsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefaklorsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefaleksinsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefazolinsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefdinirsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefepimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefiksimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefoksitinsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefotaksimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefotetansefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefpodoksimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefprozilsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SeftarolinsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SeftazidimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SeftriaksonsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SefuroksimsefalosporinModerat

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (label Asam etakrinat, Interaksi obat)

  • SelekoksibOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • SertralinSSRIModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (label Sertralin, Peringatan dan perhatian)

  • Siklobenzaprinpelemas ototModerat

    …concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (label Siklobenzaprin, Interaksi obat)

  • SiklofosfamidimunosupresanModerat

    …inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity ● Amiodarone… (label Siklofosfamid, Interaksi obat)

  • Sildenafilpenghambat PDE5Moderat

    Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (label Sildenafil, Peringatan dan perhatian)

  • Silodosinpenyekat alfaModerat

    However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (label Silodosin, Peringatan dan perhatian)

  • SitalopramSSRIModerat

    Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (label Sitalopram, Peringatan dan perhatian)

  • SorafenibModerat

    Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (label Sorafenib, Peringatan dan perhatian)

  • Sotalolpenyekat betaModerat

    Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (label Sotalol, Peringatan dan perhatian)

  • Suksinilkolinpenyekat neuromuskularModerat

    Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (label Suksinilkolin, Peringatan dan perhatian)

  • Drug Interactions In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. (label Sulfametoksazol dan trimetoprim (kotrimoksazol), Interaksi obat)

  • SulindakOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • SunitinibModerat

    Initiate and/or adjust antihypertensive therapy as appropriate. (label Sunitinib, Peringatan dan perhatian)

  • TakrolimusimunosupresanModerat

    • Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (label Takrolimus, Peringatan dan perhatian)

  • TapentadolopioidModerat

    …use of skeletal muscle relaxants and opioids, consider prescribing naloxone for the emergency treatment of opioid overdose [see Dosage and Administration (2.2) , Warnings and Precautions (5.2 , 5.3) ] Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Tapentadol, Interaksi obat)

  • Telmisartanpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of therapy with telmisartan tablets. (label Telmisartan, Peringatan dan perhatian)

  • Telmisartan dan amlodipinpenghambat reseptor angiotensin II (ARB)Moderat

    Hypotension Telmisartan In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of therapy with telmisartan and amlodipine tablets. (label Telmisartan dan amlodipin, Peringatan dan perhatian)

  • Terazosinpenyekat alfaModerat

    Risk of Hypotension with Concomitant Use of Other Antihypertensive Agents and Phospodiesterase Type 5 Inhibitors (PDE5-I): Concomitant administration of TEZRULY with antihypertensives or phosphodiesterase-5 (PDE-5) inhibitors can result in additive blood pressure lowering effects and symptomatic hypotension (5.3). (label Terazosin, Peringatan dan perhatian)

  • Terbutalinagonis beta-adrenergikModerat

    Diuretics The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. (label Terbutalin, Perhatian)

  • TestosteronandrogenModerat

    In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (label Testosteron, Peringatan dan perhatian)

  • TolmetinOAINSModerat

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. (label Asam etakrinat, Interaksi obat)

  • TolvaptanModerat

    Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (label Tolvaptan, Peringatan dan perhatian)

  • Toremifenmodulator reseptor estrogen selektifModerat

    Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (label Toremifen, Interaksi obat)

  • TramadolopioidModerat

    Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Tramadol, Interaksi obat)

  • Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (label Tramadol dan parasetamol, Interaksi obat)

  • Trandolaprilpenghambat ACEModerat

    Symptomatic hypotension is most likely to occur in patients who have been salt- or volume-depleted as a result of prolonged treatment with diuretics, dietary salt restriction, dialysis, diarrhea, or vomiting. (label Trandolapril, Peringatan)

  • TrazodonantidepresanModerat

    Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (label Trazodon, Peringatan dan perhatian)

  • TrifluoperazinantipsikotikModerat

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (label Trifluoperazin, Perhatian)

  • Umeklidinium dan vilanterolantikolinergikModerat

    • Diuretics: Use with caution. (label Umeklidinium dan vilanterol, Interaksi obat)

  • Valsartanpenghambat reseptor angiotensin II (ARB)Moderat

    In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. (label Valsartan, Peringatan dan perhatian)

  • Vardenafilpenghambat PDE5Moderat

    Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (label Vardenafil, Interaksi obat)

  • VenlafaksinSNRIModerat

    Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (label Venlafaksin, Peringatan dan perhatian)

  • Verapamilpenghambat kanal kalsiumModerat

    Control patients with milder ventricular dysfunction, if possible, with optimum doses of digitalis and/or diuretics before verapamil treatment is started [see Drug Interactions ( 7.5 )] . (label Verapamil, Peringatan dan perhatian)

  • VilazodonSSRIModerat

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (label Vilazodon, Peringatan dan perhatian)

  • VortioksetinantidepresanModerat

    Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (label Vortioksetin, Peringatan dan perhatian)

  • WarfarinantikoagulanModerat

    A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (label Asam etakrinat, Interaksi obat)

  • ZiprasidonantipsikotikModerat

    Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (label Ziprasidon, Peringatan dan perhatian)

Penyebutan minor (64)

  • AkarbosaantidiabetesMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. (label Akarbosa, Interaksi obat)

  • Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (label Ambrisentan, Peringatan dan perhatian)

  • Azelastin dan flutikasonantihistaminMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • BeklometasonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Benzilpenisilin (penisilin G)antibiotik penisilinMinor

    These drugs include: aspirin, phenylbutazone, sulfonamides, indomethacin, thiazide diuretics, furosemide and ethacrynic acid. (label Benzilpenisilin (penisilin G), Interaksi obat)

  • Betaksololpenyekat betaMinor

    In hypertensive patients who have congestive heart failure controlled by digitalis and diuretics, beta-blockers should be administered cautiously. (label Betaksolol, Peringatan)

  • BetametasonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Bosentanpenginduksi CYP3A4Minor

    Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (label Bosentan, Peringatan dan perhatian)

  • BudesonidkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • ButorfanolopioidMinor

    In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive drugs. (label Butorfanol, Peringatan)

  • Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (label Dasatinib, Peringatan dan perhatian)

  • DeflazakortkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • DeksametasonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Dekstroamfetaminstimulan SSPMinor

    Antihypertensives Amphetamines may antagonize the hypotensive effects of antihypertensives. (label Dekstroamfetamin, Interaksi obat)

  • Desogestrel dan etinilestradiolkontrasepsi oralMinor

    If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (label Desogestrel dan etinilestradiol, Peringatan)

  • DesonidkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (label Dosetaksel, Peringatan dan perhatian)

  • DronedaronantiaritmiaMinor

    Hypokalemia and Hypomagnesemia with Potassium-Depleting Diuretics Hypokalemia or hypomagnesemia may occur with concomitant administration of potassium-depleting diuretics. (label Dronedaron, Peringatan dan perhatian)

  • EfedrinsimpatomimetikMinor

    Examples: α-adrenergic antagonists, β-adrenergic receptor antagonists, reserpine, quinidine, mephentermine Other Drug Interactions G u anethidine C linical Impact: Ephedrine may inhibit the neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. (label Efedrin, Interaksi obat)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (label Estrogen teresterifikasi dan metiltestosteron, Peringatan)

  • Finasteridpenghambat 5-alfa reduktaseMinor

    …clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives… (label Finasterid, Interaksi obat)

  • FlekainidantiaritmiaMinor

    Flecainide acetate has been used in a large number of patients receiving diuretics without apparent interaction. (label Flekainid, Interaksi obat)

  • FlunisolidkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • FluosinonidkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • FlutikasonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • GlibenklamidsulfonilureaMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (label Glibenklamid, Interaksi obat)

  • Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (label Glibenklamid dan metformin, Interaksi obat)

  • Glipizid dan metforminsulfonilureaMinor

    These drugs include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (label Glipizid dan metformin, Perhatian)

  • HalobetasolkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • HidralazinvasodilatorMinor

    When other potent parenteral antihypertensive drugs, such as diazoxide, are used in combination with hydralazine, patients should be continuously observed for several hours for any excessive fall in blood pressure. (label Hidralazin, Interaksi obat)

  • HidrokortisonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (label Ikatibant, Interaksi obat)

  • Imatinibpenghambat CYP3A4Minor

    Weigh patients regularly and manage unexpected rapid weight gain by drug interruption and diuretics. (label Imatinib, Peringatan dan perhatian)

  • Atypical Antipsychotics (e.g., olanzapine and clozapine), Corticosteroids, Danazol, Diuretics, Estrogens, Glucagon, Isoniazid, Niacin, Oral Contraceptives, Phenothiazines, Progestogens (e.g., in oral contraceptives), Protease inhibitors, Somatropin, Sympathomimetic Agents (e.g., albuterol, epinephrine, terbutaline) and Thyroid Hormones. (label Insulin reguler (manusia), Interaksi obat)

  • Isradipinpenghambat kanal kalsium dihidropiridinMinor

    In a study in hypertensive patients, addition of isradipine to existing hydrochlorothiazide therapy did not result in any unexpected adverse effects, and isradipine had an additional antihypertensive effect. (label Isradipin, Interaksi obat)

  • KaliumVitamin dan mineralMinor

    Diuretik loop dan diuretik tiazid meningkatkan kehilangan kalium; suplementasi kadang diresepkan bersamanya. (NIH Office of Dietary Supplements, Potassium)

  • Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (label Kalsium glukonat, Interaksi obat)

  • KlobetasolkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (label Kortikotropin, Interaksi obat)

  • Linagliptin dan metforminpenghambat DPP-4Minor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (label Linagliptin dan metformin, Interaksi obat)

  • MagnesiumVitamin dan mineralMinor

    Penggunaan jangka panjang diuretik loop dan diuretik tiazid meningkatkan kehilangan magnesium melalui urine. (NIH Office of Dietary Supplements, Magnesium)

  • Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (label Masitentan, Peringatan dan perhatian)

  • MeksiletinantiaritmiaMinor

    In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (label Meksiletin, Interaksi obat)

  • MetforminbiguanidMinor

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (label Metformin, Interaksi obat)

  • MetildopaantihipertensiMinor

    Drug Interactions When methyldopa is used with other antihypertensive drugs, potentiation of antihypertensive effect may occur. (label Metildopa, Interaksi obat)

  • MetilprednisolonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • MetiltestosteronandrogenMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (label Metiltestosteron, Peringatan)

  • MometasonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Nisoldipinpenghambat kanal kalsium dihidropiridinMinor

    The blood pressure effect of SULAR tended to be greater in patients on atenolol than in patients on no other antihypertensive therapy. (label Nisoldipin, Interaksi obat)

  • NitroprusidvasodilatorMinor

    Hypertensive patients, and patients concomitantly receiving other antihypertensive medications, may be more sensitive to the effects of sodium nitroprusside than normal subjects. (label Nitroprusid, Peringatan)

  • Nortriptilinantidepresan trisiklikMinor

    The antihypertensive action of guanethidine and similar agents may be blocked. (label Nortriptilin, Peringatan)

  • Olopatadin dan mometasonantihistaminMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Pioglitazon dan metformintiazolidindionMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (label Pioglitazon dan metformin, Interaksi obat)

  • Piperasilin dan tazobaktamantibiotik penisilinMinor

    Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (label Piperasilin dan tazobaktam, Peringatan dan perhatian)

  • PrednisolonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • PrednisonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Protriptilinantidepresan trisiklikMinor

    Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (label Protriptilin, Peringatan)

  • RepaglinidmeglitinidMinor

    Examples: Atypical antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and… (label Repaglinid, Interaksi obat)

  • Saksagliptin dan metforminpenghambat DPP-4Minor

    These medications include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (label Saksagliptin dan metformin, Interaksi obat)

  • SiklesonidkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

  • Sitagliptin dan metforminpenghambat DPP-4Minor

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (label Sitagliptin dan metformin, Interaksi obat)

  • SulfadiazinsulfonamidaMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (label Sulfadiazin, Interaksi obat)

  • TerbinafinantijamurMinor

    There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, phenytoins, thiazide diuretics, and calcium channel blockers. (label Terbinafin, Interaksi obat)

  • TriamsinolonkortikosteroidMinor

    Care should also be exercised in patients receiving potassium-depleting steroids. (label Asam etakrinat, Peringatan)

Tidak ada interaksi bermakna yang dilaporkan (1)

  • PamidronatbisfosfonatTanpa interaksi

    Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (label Pamidronat, Interaksi obat)

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