Interaksi Anagrelid dan Aspirin dan dipiridamol

Risk factors for bleeding include the use of other drugs that increase the risk of bleeding (e.g., anticoagulants, antiplatelet agents, heparin, anagrelide, fibrinolytic therapy, and chronic use of NSAIDs) [see Drug Interactions ( 7.1 )].

Anagrelide Patients taking aspirin in combination with anagrelide are at an increased risk of bleeding.

Bleeding Risk Use of concomitant AGRYLIN and aspirin increased major hemorrhagic events in a postmarketing study.

Assess the potential risks and benefits for concomitant use of AGRYLIN with aspirin, since bleeding risks may be increased.

Aspirin and Drugs that Increase Bleeding Risk : Increased risk of bleeding with concomitant use.

Aspirin and Drugs that Increase Bleeding Risk Co-administration of single-dose or repeat-dose AGRYLIN and aspirin showed greater ex vivo anti-platelet aggregation effects than administration of aspirin alone [see Clinical Pharmacology (12.3) ] .

Therefore, the potential risks of the concomitant use of AGRYLIN with aspirin should be assessed, particularly in patients with a high-risk profile for hemorrhage, before treatment is initiated [see Warnings and Precautions (5.3) ] .