Interaksi Siprofloksasin dan Levofloksasin
Siprofloksasin dan Levofloksasin: kedua label peresepan menandai kombinasi ini dengan bahasa yang paling tegas, seperti kontraindikasi, peringatan kotak hitam, atau instruksi untuk menghindarinya.
Jangan dikombinasikan tanpa arahan dokter yang meresepkan. Bahasa label di bawah ini adalah yang paling tegas yang digunakan FDA.
Apa kata label FDA
Dari label Siprofloksasin (Ciprofloxacin) · berlaku sejak 2026-06-30
Click here to enter Contraindications Known hypersensitivity to ciprofloxacin or other quinolones ( 4.1 , 5.6, 5.7 )
Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.
Ciprofloxacin, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold.
Dari label Levofloksasin (Levofloxacin) · berlaku sejak 2024-05-22
Levofloxacin in 5% Dextrose Injection is contraindicated in persons with known hypersensitivity to levofloxacin, or other quinolone antibacterials [see Warnings and Precautions (5.3) ].
Known hypersensitivity to Levofloxacin in 5% Dextrose Injection or other quinolones ( 4 , 5.7 ).
Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval ( 5.11 , 8.5 )
As with other fluoroquinolones, Levofloxacin in 5% Dextrose Injection should be used with caution in patients with a known or suspected central nervous system (CNS) disorder that may predispose them to seizures or lower the seizure threshold (e.g., severe cerebral arteriosclerosis, epilepsy) or in the presence of other risk factors that may predispose them to…
However, concomitant administration of other fluoroquinolones with theophylline has resulted in prolonged elimination half-life, elevated serum theophylline levels, and a subsequent increase in the risk of theophylline-related adverse reactions in the patient population.
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