Interaksi Dapson dan Trimetoprim
Dapson dan Trimetoprim: label peresepan Dapson menguraikan interaksi yang biasanya memerlukan pemantauan, perubahan dosis, atau pemberian jarak antardosis.
Biasanya dapat dikelola dengan pemantauan atau perubahan dosis. Beri tahu apoteker Anda bahwa Anda menggunakan keduanya.
Apa kata label FDA
Dari label Dapson (Dapsone) · berlaku sejak 2026-07-20
However, an earlier report 2 also by Lee et al, in 78 HIV infected patients with acute Pneumocystis carinii pneumonia, receiving dapsone, 100 mg/day and higher trimethoprim dose, 20 mg/kg/day, demonstrated that the serum levels of dapsone were increased by 40% and trimethoprim levels were increased by 48% when the drugs were administered concurrently.
A modest interaction has been reported for patients receiving 100 mg dapsone daily in combination with trimethoprim 5 mg/kg q6h.
On Day 7, trimethoprim levels averaged 18.4 ± 5.2 μg/mL in comparison to 12.4 ± 4.5 μg/mL for patients not receiving dapsone.
Thus, there is a mutual interaction between dapsone and trimethoprim in which each raises the level of the other about 1.5 times.
A crossover study 1 designed to assess the potential of a drug interaction between dapsone, 100 mg/day and trimethoprim, 200 mg every 12 hours, in eight asymptomatic HIV positive volunteers (average CD4 count 524 cells/mm 3 ) demonstrated that there was not a significant drug interaction between dapsone and trimethoprim.
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