Interaksi Deksametason dan Lenakapavir
Deksametason dan Lenakapavir: kedua label peresepan menandai kombinasi ini dengan bahasa yang paling tegas, seperti kontraindikasi, peringatan kotak hitam, atau instruksi untuk menghindarinya.
Jangan dikombinasikan tanpa arahan dokter yang meresepkan. Bahasa label di bawah ini adalah yang paling tegas yang digunakan FDA.
Apa kata label FDA
Dari label Deksametason (Hemady) · berlaku sejak 2026-01-09
• Avoid concomitant use of strong CYP3A4 inhibitors or inducers.
Avoid coadministration of strong CYP3A4 inhibitors or consider alternative medication that are not strong CYP3A4 inhibitors.
If concomitant use of strong CYP3A4 inhibitors cannot be avoided, closely monitor for adverse drug reactions.
( 7.2 ) 7.1 Effect of Other Drugs on HEMADY Strong CYP3A4 inhibitors Coadministration of strong and moderate CYP3A4 inhibitors increased dexamethasone exposure [see Clinical Pharmacology ( 12.3 )] , which may increase the risk of adverse reactions [see Warnings and Precautions ( 5 ) and Adverse Reactions ( 6 )] .
Dari label Lenakapavir (Sunlenca) · berlaku sejak 2026-08-27
Concomitant administration of SUNLENCA with strong CYP3A inducers is contraindicated due to decreased lenacapavir plasma concentrations, which may result in the loss of therapeutic effect and development of resistance to SUNLENCA [see Drug Interactions (7.1) ] .
Concomitant administration of SUNLENCA is contraindicated with strong CYP3A inducers.
Concomitant administration of SUNLENCA with strong CYP3A inducers during SUNLENCA treatment is contraindicated [see Contraindications (4) ] .
Concomitant administration of SUNLENCA with moderate CYP3A inducers during SUNLENCA treatment is not recommended.
Initiate with the lowest starting dose and titrate carefully while monitoring for safety. ↓ lenacapavir (dexamethasone) Concomitant administration of systemic dexamethasone may result in loss of therapeutic effect of lenacapavir and development of resistance.
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