Interaksi Fenofibrat dan Pravastatin
Fenofibrat dan Pravastatin: kedua label peresepan menguraikan interaksi yang biasanya memerlukan pemantauan, perubahan dosis, atau pemberian jarak antardosis.
Biasanya dapat dikelola dengan pemantauan atau perubahan dosis. Beri tahu apoteker Anda bahwa Anda menggunakan keduanya.
Apa kata label FDA
Dari label Fenofibrat (Fenofibrate) · berlaku sejak 2026-05-12
Risks are increased during co-administration with a statin, in geriatric patients and in patients with renal impairment, or hypothyroidism.
Pemafibrate did not reduce cardiovascular disease morbidity or mortality in a large, randomized, placebo - controlled trial of patients with type 2 diabetes mellitus on background statin therapy [see Clinical Studies (14.4) ].
Steps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis Data from observational studies indicate that the risk for rhabdomyolysis is increased when fibrates, including fenofibrates, are co-administered with a statin.
The risk of myopathy and rhabdomyolysis is increased with concomitant use of fibrates with statins.
Intervention: Consider if the benefit of using fenofibrate concomitantly with statin therapy outweighs the increased risk of myopathy and rhabdomyolysis.
Dari label Pravastatin (Pravastatin Sodium) · berlaku sejak 2026-08-17
The following drugs when used concomitantly with pravastatin sodium may also increase the risk of myopathy and rhabdomyolysis: niacin, fibrates, and colchicine [see Drug Interactions ( 7 )].
The risk of myopathy and rhabdomyolysis is increased with concomitant use of fibrates with pravastatin sodium.
Intervention: Consider if the benefit of using fibrates concomitantly with pravastatin sodium outweighs the increased risk of myopathy and rhabdomyolysis.
Fibrates (other than Gemfibrozil) Clinical Impact: Fibrates may cause myopathy when given alone.
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