Interaksi Ketoprofen dan Triamteren dan hidroklorotiazid

Caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide.

Nonsteroidal Anti-Inflammatory Drugs A possible interaction resulting in acute renal failure has been reported in a few patients on triamterene and hydrochlorothiazide when treated with indomethacin, a nonsteroidal anti-inflammatory agent.

Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.

Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics, and the elderly.

Diuretics NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition (see PRECAUTIONS ).

Patients at greater risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE-inhibitors, and the elderly.