Interaksi Asam mefenamat dan Tolmetin

History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

Avoid administration of more than one NSAID at a time.

Exacerbation of Asthma Related to Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs.

Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, mefenamic acid is contraindicated in patients with this form of aspirin sensitivity [see Contraindications ( 4 )] .

Intervention: The concomitant use of mefenamic acid with other NSAIDs or salicylates is not recommended.

TOLECTIN should not be given to patients who have experienced asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs.

This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs (see CONTRAINDICATIONS and PRECAUTIONS: General : Preexisting Asthma ).

Aspirin: As with other NSAIDs, concomitant administration of TOLECTIN sodium and aspirin is not generally recommended because of the potential of increased adverse effects.

Anaphylactoid Reactions As with other NSAIDs, anaphylactoid reactions may occur in patients with known prior exposure to TOLECTIN.