Interaksi Moksifloksasin dan Ofloksasin

Known hypersensitivity to moxifloxacin or other quinolones.

Pharmacokinetic studies between moxifloxacin and other drugs that prolong the QT interval such as cisapride, erythromycin, antipsychotics, and tricyclic antidepressants have not been performed.

Drugs that Prolong QT There is limited information available on the potential for a pharmacodynamic interaction in humans between moxifloxacin and other drugs that prolong the QTc interval of the electrocardiogram.

Therefore, until more information becomes available, ofloxacin, like all other quinolones, should be used with caution in patients with known or suspected CNS disorders, such as severe cerebral arteriosclerosis, epilepsy, and other factors which predispose to seizures (see ADVERSE REACTIONS ).

As with other quinolones, concomitant administration of ofloxacin may prolong the half-life of theophylline, elevate serum theophylline levels, and increase the risk of theophylline-related adverse reactions.

Other quinolones also produce similar erosions in the weight-bearing joints and other signs of arthropathy in immature animals of various species ( see ANIMAL PHARMACOLOGY ).

Cyclosporine Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with some other quinolones.

Probenecid The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion.