Atovaquone and Doxycycline interaction
Atovaquone and Doxycycline: the Atovaquone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Atovaquone (MEPRON) label · effective 2026-03-20
• Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering.
Monitor patients for potential loss of efficacy of MEPRON if coadministration of tetracycline is necessary.
Tetracycline Concomitant administration of tetracycline and MEPRON oral suspension has been associated with a reduction in plasma concentrations of atovaquone [see Clinical Pharmacology ( 12.3 )].
Caution should be used when prescribing tetracycline concomitantly with MEPRON oral suspension.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.