Doxycycline interactions
Doxycycline (Vibramycin, Doryx, Oracea), a tetracycline antibiotic has 71 documented interactions across the FDA labels and fact sheets we index: 9 major, 46 moderate, 15 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
Major interactions (9)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Concomitant use of isotretinoin and doxycycline hyclate should be avoided because isotretinoin is also known to cause pseudotumor cerebri. (Doxycycline label, Warnings and precautions)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
Doxycycline Administered with rifampin (10 mg/kg daily) Decrease exposure Irinotecan Administered with an antibiotic regimen including rifampin (450 mg/day), isoniazid (300 mg/day), and streptomycin (0.5 g/day) IM Prevention or Management: Avoid the use of rifampin, a strong CYP3A4 inducer, if possible. (Rifampin label, Drug interactions)
Doxycycline hyclate are contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. (Doxycycline label, Contraindications)
Moderate interactions (46)
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
- Atovaquone and proguanilantimalarialModerate
• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)
- BrivaracetamanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- Butalbital, acetaminophen, and caffeinebarbiturateModerate
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)
- Cannabidiol (prescription)anticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- CenobamateanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- Cholestyraminebile acid sequestrantModerate
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)
- ClobazambenzodiazepineModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- DabigatrananticoagulantModerate
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- EdoxabananticoagulantModerate
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
- EnoxaparinanticoagulantModerate
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
- EslicarbazepineanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- EthosuximideanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- FelbamateanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- FondaparinuxanticoagulantModerate
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
…antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Glimepiride label, Drug interactions)
- HeparinanticoagulantModerate
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
Iron binds these drugs in the gut and reduces their absorption; separate the doses. (NIH Office of Dietary Supplements, Iron)
- LacosamideanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Magnesium-containing supplements and antacids reduce absorption of these drugs; separate the doses by at least two hours. (NIH Office of Dietary Supplements, Magnesium)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- PerampanelanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- Phentermine and topiramateCNS stimulantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (Quinapril label, Drug interactions)
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
- RufinamideanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- SucralfateModerate
Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (Sucralfate label, Drug interactions)
- TiagabineanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- TretinoinretinoidModerate
The concomitant use of other products (e.g., tetracyclines) that can cause intracranial hypertension may increase the risk. (Tretinoin label, Warnings and precautions)
- Valproic acidanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
- VigabatrinanticonvulsantModerate
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)
Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)
Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)
Minor mentions (15)
Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)
- Bismuth subsalicylatesalicylateMinor
Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)
- Conjugated estrogensestrogenMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- Deferasiroxiron supplementMinor
Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)
- Drospirenone and ethinyl estradioloral contraceptiveMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- LevonorgestrelprogestinMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- MegestrolprogestinMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- NorethindroneprogestinMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- Norgestimate and ethinyl estradioloral contraceptiveMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- ProgesteroneprogestinMinor
Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)
- Sodium bicarbonateantacidMinor
Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)
No significant interaction reported (1)
…ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (Theophylline label, Drug interactions)
Check Doxycycline against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.