Doxycycline interactions

Doxycycline (Vibramycin, Doryx, Oracea), a tetracycline antibiotic has 71 documented interactions across the FDA labels and fact sheets we index: 9 major, 46 moderate, 15 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (9)

  • Amoxicillinpenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • Ampicillinpenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • Dicloxacillinpenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • IsotretinoinretinoidMajor

    Concomitant use of isotretinoin and doxycycline hyclate should be avoided because isotretinoin is also known to cause pseudotumor cerebri. (Doxycycline label, Warnings and precautions)

  • Penicillin Gpenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • Penicillin Vpenicillin antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • RifampinantibioticMajor

    Doxycycline Administered with rifampin (10 mg/kg daily) Decrease exposure Irinotecan Administered with an antibiotic regimen including rifampin (450 mg/day), isoniazid (300 mg/day), and streptomycin (0.5 g/day) IM Prevention or Management: Avoid the use of rifampin, a strong CYP3A4 inducer, if possible. (Rifampin label, Drug interactions)

  • Tetracyclinetetracycline antibioticMajor

    Doxycycline hyclate are contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. (Doxycycline label, Contraindications)

Moderate interactions (46)

  • ApixabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • Atovaquone and proguanilantimalarialModerate

    Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • BrivaracetamanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • Butalbital, acetaminophen, and caffeinebarbiturateModerate

    Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • CalciumVitamin and mineralModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Cannabidiol (prescription)anticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • CarbamazepineanticonvulsantModerate

    Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • CenobamateanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • Cholestyraminebile acid sequestrantModerate

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

  • ClobazambenzodiazepineModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • ClonazepambenzodiazepineModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • DabigatrananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • Divalproex (valproate)anticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • EdoxabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • EslicarbazepineanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • EthosuximideanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • FelbamateanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • GabapentinanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Glimepiride label, Drug interactions)

  • HeparinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • IronVitamin and mineralModerate

    Iron binds these drugs in the gut and reduces their absorption; separate the doses. (NIH Office of Dietary Supplements, Iron)

  • LacosamideanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • LamotrigineanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • LevetiracetamanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • MagnesiumVitamin and mineralModerate

    Magnesium-containing supplements and antacids reduce absorption of these drugs; separate the doses by at least two hours. (NIH Office of Dietary Supplements, Magnesium)

  • OxcarbazepineanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • PerampanelanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • PhenobarbitalbarbiturateModerate

    Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • Phentermine and topiramateCNS stimulantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • PregabalinanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • PrimidoneanticonvulsantModerate

    Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • QuinaprilACE inhibitorModerate

    Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (Quinapril label, Drug interactions)

  • RivaroxabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • RufinamideanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • SucralfateModerate

    Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (Sucralfate label, Drug interactions)

  • TiagabineanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • TopiramateanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • TretinoinretinoidModerate

    The concomitant use of other products (e.g., tetracyclines) that can cause intracranial hypertension may increase the risk. (Tretinoin label, Warnings and precautions)

  • Valproic acidanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • VigabatrinanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

  • WarfarinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Doxycycline label, Drug interactions)

  • ZincVitamin and mineralModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • ZonisamideanticonvulsantModerate

    Barbiturates and Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. (Doxycycline label, Drug interactions)

Minor mentions (15)

  • Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)

  • Bismuth subsalicylatesalicylateMinor

    Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)

  • Conjugated estrogensestrogenMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • Deferasiroxiron supplementMinor

    Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)

  • Drospirenone and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • EstradiolestrogenMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • LevonorgestrelprogestinMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • MedroxyprogesteroneprogestinMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • MegestrolprogestinMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • NorethindroneprogestinMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • ProgesteroneprogestinMinor

    Concurrent use of tetracyclines, including doxycycline hyclate may render oral contraceptives less effective. (Doxycycline label, Drug interactions)

  • Sodium bicarbonateantacidMinor

    Absorption of tetracyclines, including doxycycline hyclate is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. (Doxycycline label, Drug interactions)

No significant interaction reported (1)

  • TheophyllinemethylxanthineNo interaction

    …ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (Theophylline label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.