Calcitriol and Ketoconazole interaction
Calcitriol and Ketoconazole: the Calcitriol prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Calcitriol label · effective 2026-07-10
Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men.
Ketoconazole Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol.
However, in vivo drug interaction studies of ketoconazole with calcitriol have not been investigated.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.