Interaction Checker

Calcitriol interactions

Calcitriol (Rocaltrol), a vitamin D analog has 47 documented interactions across the FDA labels and fact sheets we index: 9 major, 19 moderate, 19 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (9)

  • Antacids (Tums, Maalox, Mylanta)OTC productMajor

    Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Calcitriol label, Warnings)

  • CalciumVitamin and mineralMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • Felodipinedihydropyridine calcium channel blockerMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • Isradipinedihydropyridine calcium channel blockerMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • MagnesiumVitamin and mineralMajor

    Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Calcitriol label, Warnings)

  • Nifedipinedihydropyridine calcium channel blockerMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • Nisoldipinedihydropyridine calcium channel blockerMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • Sodium bicarbonateantacidMajor

    Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Calcitriol label, Warnings)

  • Vitamin DVitamin and mineralMajor

    CONTRAINDICATIONS Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. (Calcitriol label, Contraindications)

Moderate interactions (19)

  • Bisoprolol and hydrochlorothiazidebeta blockerModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Chlorthalidonethiazide diureticModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Cholestyraminebile acid sequestrantModerate

    DRUG INTERACTIONS Cholestyramine Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of calcitriol (see WARNINGS and PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • DenosumabModerate

    Monitor calcium levels during therapy, especially in the first weeks of initiating therapy, and adequately supplement all patients with calcium and vitamin D. (Denosumab label, Warnings and precautions)

  • Digoxindigitalis glycosideModerate

    Digitalis Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • IbandronatebisphosphonateModerate

    Instruct patients to take supplemental calcium and vitamin D if their dietary intake is inadequate (see Dosage and Administration [2.3] ) . (Ibandronate label, Warnings and precautions)

  • Indapamidethiazide diureticModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Ketoconazoleazole antifungalModerate

    Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. (Calcitriol label, Drug interactions)

  • Lisinopril and hydrochlorothiazideACE inhibitorModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Metolazonethiazide diureticModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • OrlistatModerate

    The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (Orlistat label, Drug interactions)

  • PhenobarbitalbarbiturateModerate

    Phenytoin/Phenobarbital The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. (Calcitriol label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    Phenytoin/Phenobarbital The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. (Calcitriol label, Drug interactions)

  • RisedronatebisphosphonateModerate

    Calcium Supplements/Antacids When Risedronate sodium delayed-release was administered following breakfast, the co-administration of a tablet containing 600 mg of elemental calcium and 400 international units vitamin D reduced risedronate bioavailability by approximately 38% [ see Clinical Pharmacology (12.3) ] . (Risedronate label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Calcitriol label, Drug interactions)

Minor mentions (19)

  • AlendronatebisphosphonateMinor

    Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (Alendronate label, Warnings and precautions)

  • BeclomethasonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • BetamethasonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • BudesonidecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • Budesonide and formoterolcorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • ClobetasolcorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • DesonidecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • DexamethasonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • FludrocortisonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • FluocinonidecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • FluticasonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • Fluticasone and salmeterolcorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • HalobetasolcorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • HydrocortisonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • MethylprednisolonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • MometasonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • PrednisolonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • PrednisonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

  • TriamcinolonecorticosteroidMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Calcitriol label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.