Carvedilol and Diltiazem interaction
Carvedilol and Diltiazem: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Carvedilol (Coreg) label · effective 2026-07-31
COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents.
As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.
Verapamil- or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure.
Calcium Channel Blockers Conduction disturbance (rarely with hemodynamic compromise) has been observed when COREG is coadministered with diltiazem.
From the Diltiazem (Cardizem LA) label · effective 2025-11-11
Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.
• Beta-blockers, digitalis, and other agents known to impair cardiac contractility and conduction may increase risk for hypotension, bradycardia, and heart failure.
Experience with the use of diltiazem in combination with beta-blockers in patients with impaired ventricular function is limited.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.