Carvedilol and Diltiazem interaction
Carvedilol and Diltiazem: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diltiazem (DILTIAZEM HYDROCHLORIDE in SODIUM CHLORIDE) label · effective 2025-04-15
• Concomitant administration with IV beta-blockers.
Beta-blockers Increased risk of bradycardia, AV block, and depression of contractility.
Beta-blocker may need to be decreased [see Warnings and Precautions (5.1, 5.2)].
• Beta-Blockers: Monitor for bradycardia, AV block, and depression of contractility.
From the Carvedilol (Coreg) label · effective 2026-07-31
COREG may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents.
As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.
Verapamil- or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure.
Calcium Channel Blockers Conduction disturbance (rarely with hemodynamic compromise) has been observed when COREG is coadministered with diltiazem.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.