Cholestyramine and Colesevelam interaction
Cholestyramine and Colesevelam: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Colesevelam (COLESEVELAM HYDROCHLORIDE) label · effective 2023-12-28
Hypertriglyceridemia and Pancreatitis Colesevelam hydrochloride, like other bile acid sequestrants, can increase serum TG concentrations.
From the Cholestyramine label · effective 2026-06-15
Interference with the absorption of oral phosphate supplements has been observed with another positively-charged bile acid sequestrant.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.