Interaction Checker

Raloxifene interactions

Raloxifene (Evista), a selective estrogen receptor modulator has 43 documented interactions across the FDA labels and fact sheets we index: 8 major, 11 moderate, 24 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (8)

  • Cholestyraminebile acid sequestrantMajor

    Cholestyramine : Use with EVISTA is not recommended. (Raloxifene label, Drug interactions)

  • Colesevelambile acid sequestrantMajor

    EVISTA should not be co-administered with other anion exchange resins [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Conjugated estrogensestrogenMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

  • Drospirenone and ethinyl estradioloral contraceptiveMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

  • EstradiolestrogenMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

  • Levonorgestrel and ethinyl estradioloral contraceptiveMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

  • Norethindrone and ethinyl estradioloral contraceptiveMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

  • Norgestimate and ethinyl estradioloral contraceptiveMajor

    Concomitant Use with Systemic Estrogens : Not recommended. (Raloxifene label, Warnings and precautions)

Moderate interactions (11)

  • DiazepambenzodiazepineModerate

    Other Highly Protein-Bound Drugs EVISTA should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine. (Raloxifene label, Drug interactions)

  • FamciclovirantiviralModerate

    Raloxifene, a potent aldehyde oxidase inhibitor in vitro , could decrease the formation of penciclovir. (Famciclovir label, Drug interactions)

  • LevonorgestrelprogestinModerate

    History of Hypertriglyceridemia when Treated with Estrogens Limited clinical data suggest that some women with a history of marked hypertriglyceridemia (>5.6 mmol/L or >500 mg/dL) in response to treatment with oral estrogen or estrogen plus progestin may develop increased levels of triglycerides when treated with EVISTA. (Raloxifene label, Warnings and precautions)

  • Lidocainelocal anestheticModerate

    Other Highly Protein-Bound Drugs EVISTA should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine. (Raloxifene label, Drug interactions)

  • Lidocaine and prilocainelocal anestheticModerate

    Other Highly Protein-Bound Drugs EVISTA should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine. (Raloxifene label, Drug interactions)

  • MedroxyprogesteroneprogestinModerate

    History of Hypertriglyceridemia when Treated with Estrogens Limited clinical data suggest that some women with a history of marked hypertriglyceridemia (>5.6 mmol/L or >500 mg/dL) in response to treatment with oral estrogen or estrogen plus progestin may develop increased levels of triglycerides when treated with EVISTA. (Raloxifene label, Warnings and precautions)

  • MegestrolprogestinModerate

    History of Hypertriglyceridemia when Treated with Estrogens Limited clinical data suggest that some women with a history of marked hypertriglyceridemia (>5.6 mmol/L or >500 mg/dL) in response to treatment with oral estrogen or estrogen plus progestin may develop increased levels of triglycerides when treated with EVISTA. (Raloxifene label, Warnings and precautions)

  • NorethindroneprogestinModerate

    History of Hypertriglyceridemia when Treated with Estrogens Limited clinical data suggest that some women with a history of marked hypertriglyceridemia (>5.6 mmol/L or >500 mg/dL) in response to treatment with oral estrogen or estrogen plus progestin may develop increased levels of triglycerides when treated with EVISTA. (Raloxifene label, Warnings and precautions)

  • ProgesteroneprogestinModerate

    History of Hypertriglyceridemia when Treated with Estrogens Limited clinical data suggest that some women with a history of marked hypertriglyceridemia (>5.6 mmol/L or >500 mg/dL) in response to treatment with oral estrogen or estrogen plus progestin may develop increased levels of triglycerides when treated with EVISTA. (Raloxifene label, Warnings and precautions)

  • Tobacco and smokingTobacco and cannabisModerate

    The risk-benefit balance should be considered in women at risk for stroke, such as prior stroke or transient ischemic attack (TIA), atrial fibrillation, hypertension, or cigarette smoking [see Clinical Studies ( 14.5 )] . (Raloxifene label, Warnings and precautions)

  • WarfarinanticoagulantModerate

    Warfarin : Monitor prothrombin time when starting or stopping EVISTA. (Raloxifene label, Drug interactions)

Minor mentions (24)

  • Amoxicillinpenicillin antibioticMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Ampicillinpenicillin antibioticMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Antacids (Tums, Maalox, Mylanta)OTC productMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • BeclomethasonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • BetamethasonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • BudesonidecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Budesonide and formoterolcorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • ClobetasolcorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • DesonidecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • DexamethasonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Digoxindigitalis glycosideMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • FludrocortisonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • FluocinonidecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • FluticasonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Fluticasone and salmeterolcorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • HalobetasolcorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • HydrocortisonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • MethylprednisolonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • MometasonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • PrednisolonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • PrednisonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Sodium bicarbonateantacidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • TriamcinolonecorticosteroidMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.