Clonidine and Milnacipran interaction
Clonidine and Milnacipran: the Milnacipran prescribing label mentions this combination without an instruction to avoid it or change the dose.
Minor
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Milnacipran (Milnacipran Hydrochloride) label · effective 2026-03-19
Minor
Clonidine: Because milnacipran hydrochloride inhibits norepinephrine reuptake, co-administration with clonidine may inhibit clonidine’s anti-hypertensive effect.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.