Folic acid (folate) and Methotrexate interaction
Folic acid (folate) and Methotrexate: the Methotrexate prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Methotrexate (Xatmep) label · effective 2026-05-28
Nitrous Oxide The use of nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, resulting in the potential for increase toxicity.
Curated guidance for Folic acid (folate)
Methotrexate is a folate antagonist; folic acid is often prescribed with it to reduce side effects, but high doses can reduce its anticancer effect.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.