Folic acid (folate) and Phenobarbital interaction
Folic acid (folate) and Phenobarbital: NIH and FDA consumer guidance describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Moderate
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
Curated guidance for Folic acid (folate)
Moderate
These antiepileptic drugs lower folate levels, and folic acid supplements can in turn lower blood levels of the drug.
Curated ruleNIH Office of Dietary Supplements, Folate
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.