Folic acid (folate) and Sulfasalazine interaction
Folic acid (folate) and Sulfasalazine: the Sulfasalazine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sulfasalazine label · effective 2026-08-25
Drug Interactions: Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine.
Curated guidance for Folic acid (folate)
Sulfasalazine inhibits folate absorption and can cause folate deficiency.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.