Levonorgestrel and Levonorgestrel and ethinyl estradiol interaction
Levonorgestrel and Levonorgestrel and ethinyl estradiol: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Levonorgestrel (Skyla) label · effective 2026-03-04
…Precautions ( 5.4 )] • Postpartum endometritis or infected abortion in the past 3 months • Known or suspected uterine or cervical malignancy • Known or suspected breast cancer or other progestin-sensitive cancer, now or in the past • Uterine bleeding of unknown etiology • Untreated acute cervicitis or vaginitis, including bacterial vaginosis or other lower genital…
• Known or suspected breast cancer or other progestin-sensitive cancer ( 4 )
• Uterine perforation may occur and may reduce contraceptive effectiveness or require surgery.
In addition, perforation may reduce contraceptive efficacy and result in pregnancy.
• Partial or complete expulsion may occur, which can be unnoticed, leading to loss of contraceptive efficacy.
From the Levonorgestrel and ethinyl estradiol (Tyblume) label · effective 2026-08-27
…symptoms, migraine headaches with aura, or over age 35 with any migraine headaches [see Warnings and Precautions (5.7) ] Current or history of breast cancer or other estrogen- or progestin-sensitive cancer Liver tumors, acute viral hepatitis, or severe (decompensated) cirrhosis [see Warnings and Precautions (5.2) ] Undiagnosed abnormal uterine bleeding [see…
Breast cancer or other estrogen- or progestin-sensitive cancer.
Effects of Other Drugs on Combined Hormonal Contraceptives Substances decreasing the Plasma Concentration of CHCs and Potentially Diminishing the Efficacy of CHCs Table 3 Significant Drug Interactions Involving Substances That Affect CHCs a Induction potency of St.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.