Lisinopril and hydrochlorothiazide and Potassium interaction
Lisinopril and hydrochlorothiazide and Potassium: the Lisinopril and hydrochlorothiazide prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
Curated guidance for Potassium
These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm.
Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them.
From the Lisinopril and hydrochlorothiazide (Zestoretic) label · effective 2025-03-31
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Hyperkalemia: Patients should be told not to use salt substitutes containing potassium without consulting their physician.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.