Interaction Checker

Potassium interactions

Potassium supplements and salt substitutes can push potassium dangerously high when combined with drugs that also retain potassium.

Potassium has 42 documented interactions across the FDA labels and fact sheets we index: 30 major, 2 moderate, 10 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This vitamin and mineral page is a starting point, not a verdict for your situation.

Major interactions (30)

  • AliskirenantihypertensiveMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Amiloridepotassium-sparing diureticMajor

    Potassium supplementation in the form of medication, potassium-containing salt substitutes or a potassium-rich diet should not be used with amiloride HCl except in severe and/or refractory cases of hypokalemia. (Amiloride label, Contraindications)

  • Amlodipine and benazeprildihydropyridine calcium channel blockerMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Azilsartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • BenazeprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Candesartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • CaptoprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • EnalaprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Eplerenonealdosterone antagonistMajor

    …with: • type 2 diabetes with microalbuminuria, • serum creatinine > 2.0 mg/dL in males or >1.8 mg/dL in females, • creatinine clearance < 50 mL/min, or • concomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1) , Adverse Reactions (6.2) , Drug Interactions… (Eplerenone label, Contraindications)

  • FosinoprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • GlycopyrrolateanticholinergicMajor

    • GI Toxicity with Solid Oral Dosage Forms of Potassium Chloride : Concomitant use is not recommended. (Glycopyrrolate label, Drug interactions)

  • Irbesartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • LisinoprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Lisinopril and hydrochlorothiazideACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Losartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • MoexiprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Olmesartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • PerindoprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • QuinaprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • RamiprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Sacubitril and valsartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Spironolactonealdosterone antagonistMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMajor

    …blockers • non-steroidal anti-inflammatory drugs (NSAIDs), e.g., indomethacin • heparin and low molecular weight heparin • other drugs or conditions known to cause hyperkalemia • potassium supplements • diet rich in potassium • salt substitutes containing potassium Spironolactone and hydrochlorothiazide tablets should not be administered concurrently with other… (Spironolactone and hydrochlorothiazide label, Warnings)

  • Telmisartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • TrandolaprilACE inhibitorMajor

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Triamterenepotassium-sparing diureticMajor

    Patients should not be placed on dietary potassium supplements, potassium salts or potassium-containing salt substitutes in conjunction with Dyrenium. (Triamterene label, Contraindications)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMajor

    Concomitant potassium-containing salt substitutes should also not be used. (Triamterene and hydrochlorothiazide label, Contraindications)

  • Valsartanangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm. (NIH Office of Dietary Supplements, Potassium)

Moderate interactions (2)

  • CyclosporineimmunosuppressantModerate

    Caution is also required when cyclosporine is coadministered with potassium sparing drugs (e.g., angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists), potassium-containing drugs as well as in patients on a potassium rich diet. (Cyclosporine label, Drug interactions)

  • FludrocortisonecorticosteroidModerate

    Monitor serum potassium levels; use potassium supplements if necessary. (Fludrocortisone label, Drug interactions)

Minor mentions (10)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Bumetanideloop diureticMinor

    Supplemental potassium and/or spironolactone may prevent hypokalemia and metabolic alkalosis in these patients. (Bumetanide label, Warnings)

  • Chlorthalidonethiazide diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Ethacrynic acidloop diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Furosemideloop diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Hydrochlorothiazidethiazide diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • HyoscyamineanticholinergicMinor

    Drug interactions may occur when anticholinergics are used with the following medications: antacids, antidiarrheals (adsorbent), other anticholinergics, antimyasthenics, cyclopropane, haloperidol, ketoconazole, metoclopramide, opioid (narcotic) analgesics, and potassium chloride. (Hyoscyamine label, Drug interactions)

  • Indapamidethiazide diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Metolazonethiazide diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

  • Torsemideloop diureticMinor

    Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them. (NIH Office of Dietary Supplements, Potassium)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.