Norgestimate and ethinyl estradiol and Tobacco and smoking interaction
Norgestimate and ethinyl estradiol and Tobacco and smoking: the Norgestimate and ethinyl estradiol prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Norgestimate and ethinyl estradiol (MONO-LINYAH) label · effective 2026-06-23
WARNING: CIGARETTE SMOKING and SERIOUS CARDIOVASCULAR EVENTS WARNING: CIGARETTE SMOKING and SERIOUS CARDIOVASCULAR EVENTS See full prescribing information for complete boxed warning. ● Mono-Linyah is contraindicated in women over 35 years old who smoke.
● Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use.
Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use.
This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.