Potassium and Triamterene and hydrochlorothiazide interaction
Potassium and Triamterene and hydrochlorothiazide: the Triamterene and hydrochlorothiazide prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Triamterene and hydrochlorothiazide label · effective 2026-07-16
Concomitant potassium-containing salt substitutes should also not be used.
…with renal insufficiency: blood from blood bank (may contain potassium up to 30 mEq/L of plasma or up to 65 mEq/L of whole blood when stored for more than 10 days); low-salt milk (may contain potassium up to 60 mEq/L); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium).
Curated guidance for Potassium
These medicines reduce potassium excretion; adding potassium supplements or salt substitutes can cause hyperkalemia, which affects heart rhythm.
Loop and thiazide diuretics increase potassium loss; supplementation is sometimes prescribed alongside them.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.