Theophylline and Tiagabine interaction

Theophylline and Tiagabine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Theophylline label · effective 2026-01-29

Moderate

25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.

Drug interactionsby drug classView label on DailyMed

From the Tiagabine (Tiagabine Hydrochloride) label · effective 2021-09-30

No interaction

Theophylline : A single 10 mg dose of tiagabine did not affect the pharmacokinetics of theophylline at steady state.

Drug interactionsnames TheophyllineView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.