Metolazon: interakcje
Metolazon (Zaroxolyn), diuretyk tiazydowy: 423 udokumentowane interakcje w indeksowanych przez nas etykietach FDA i kartach informacyjnych. Poważne: 103, umiarkowane: 286, niewielkie: 32, pary, dla których etykieta nie zgłasza istotnej interakcji: 2. Każda pozycja poniżej cytuje zdanie, na którym się opiera. Ta strona leku to punkt wyjścia, a nie rozstrzygnięcie dla indywidualnej sytuacji.
Interakcje z etykiety
Poważne interakcje (103)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. (etykieta leku Bumetanid, Ostrzeżenie w ramce)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
- Choriogonadotropina alfaPoważna
Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (etykieta leku Choriogonadotropina alfa, Ostrzeżenia)
Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (etykieta leku Cyklosporyna, Interakcje z innymi lekami)
The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (etykieta leku Cytrynian potasu, Interakcje z innymi lekami)
- DiazoksydPoważna
CONTRAINDICATIONS PROGLYCEM is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides (etykieta leku Diazoksyd, Przeciwwskazania)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
In the DIAMOND trials, 1252 patients were treated with dofetilide and diuretics concomitantly, of whom 493 died compared to 508 deaths among the 1248 patients receiving placebo and diuretics. (etykieta leku Dofetylid, Interakcje z innymi lekami)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (etykieta leku Droperydol, Ostrzeżenie w ramce)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
…of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (etykieta leku Eptyfibatyd, Przeciwwskazania)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
- FolitropinaPoważna
Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (etykieta leku Folitropina, Ostrzeżenia i środki ostrożności)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (etykieta leku Gentamycyna, Ostrzeżenie w ramce)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
- IrynotekanPoważna
Avoid diuretics or laxatives in patients with diarrhea. (etykieta leku Irynotekan, Ostrzeżenia i środki ostrożności)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (etykieta leku Itrakonazol, Interakcje z innymi lekami)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (etykieta leku Klozapina, Ostrzeżenie w ramce)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (etykieta leku Neomycyna, Ostrzeżenie w ramce)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
…coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (etykieta leku Tadalafil, Ostrzeżenia i środki ostrożności)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (etykieta leku Trójtlenek arsenu, Ostrzeżenia i środki ostrożności)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)
Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (etykieta leku Wodorowęglan sodu, Przeciwwskazania)
Umiarkowane interakcje (286)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (etykieta leku Alfuzosyna, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (etykieta leku Allopurynol, Ostrzeżenia i środki ostrożności)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Ethacrynic Acid, Furosemide, Urea, or Mannitol Some diuretics can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. (etykieta leku Amikacyna, Interakcje z innymi lekami)
Give special attention to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or in patients receiving concomitant diuretics and laxatives. (etykieta leku Amiodaron, Ostrzeżenia i środki ostrożności)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (etykieta leku Arypiprazol, Interakcje z innymi lekami)
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etykieta leku Asenapina, Ostrzeżenia i środki ostrożności)
Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (etykieta leku Atomoksetyna, Interakcje z innymi lekami)
• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (etykieta leku Awanafil, Ostrzeżenia i środki ostrożności)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
- BortezomibUmiarkowana
Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (etykieta leku Bortezomib, Ostrzeżenia i środki ostrożności)
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Brekspiprazol, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Use caution in patients taking antihypertensive medications. (etykieta leku Bromokryptyna, Ostrzeżenia i środki ostrożności)
Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (etykieta leku Brymonidyna, Interakcje z innymi lekami)
Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (etykieta leku Brymonidyna + tymolol, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Diuretics: Nephrotoxicity has been reported with concomitant administration of cephalosporins with potent diuretics such as furosemide. (etykieta leku Cefepim, Interakcje z innymi lekami)
Drug Interactions Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. (etykieta leku Ceftazydym, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Drugs that alkalinize the urine ( carbonic-anhydrase inhibitors, sodium bicarbonate, thiazide diuretics ) reduce renal elimination of quinidine. (etykieta leku Chinidyna, Interakcje z innymi lekami)
- Chlorek wapniaUmiarkowana
Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (etykieta leku Chlorek wapnia, Interakcje z innymi lekami)
Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Chlorpromazyna, Środki ostrożności)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
…concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (etykieta leku Cyklobenzapryna, Interakcje z innymi lekami)
…inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity… (etykieta leku Cyklofosfamid, Interakcje z innymi lekami)
- Cyklokrzemian sodowo-cyrkonowyUmiarkowana
Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (etykieta leku Cyklokrzemian sodowo-cyrkonowy, Ostrzeżenia i środki ostrożności)
Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Cytalopram, Ostrzeżenia i środki ostrożności)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Dekslanzoprazol, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
- DesmopresynaUmiarkowana
…Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (etykieta leku Desmopresyna, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (etykieta leku Deswenlafaksyna, Ostrzeżenia i środki ostrożności)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (etykieta leku Dezypramina, Ostrzeżenia)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Digitalis Glycosides Diuretic-induced hypokalemia can increase the sensitivity of the myocardium to digitalis. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (etykieta leku Diklofenamid, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (etykieta leku Dokserkalcyferol, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (etykieta leku Drospirenon + etynyloestradiol, Ostrzeżenia i środki ostrożności)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
The risk of BP decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see Drug Interactions ( 7.1 )] and in patients taking duloxetine delayed-release capsules at doses above 60 mg daily. (etykieta leku Duloksetyna, Ostrzeżenia i środki ostrożności)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
- Epoetyna alfaUmiarkowana
Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (etykieta leku Epoetyna alfa, Ostrzeżenia i środki ostrożności)
Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (etykieta leku Epoprostenol, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (etykieta leku Escytalopram, Ostrzeżenia i środki ostrożności)
Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (etykieta leku Esmolol, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Ezomeprazol, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
…hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine Phenelzine sulfate should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result. (etykieta leku Fenelzyna, Ostrzeżenia)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
An effect of this magnitude should not necessitate a change in the fluconazole dose regimen in subjects receiving concomitant diuretics. (etykieta leku Flukonazol, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (etykieta leku Fluoksetyna, Ostrzeżenia i środki ostrożności)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (etykieta leku Fluwoksamina, Ostrzeżenia i środki ostrożności)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (etykieta leku Foskarnet, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (etykieta leku Haloperydol, Interakcje z innymi lekami)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Iloperydon, Ostrzeżenia i środki ostrożności)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (etykieta leku Imipramina, Ostrzeżenia)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
- Jodek potasuUmiarkowana
Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (etykieta leku Jodek potasu, Interakcje z innymi lekami)
Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (etykieta leku Kalcytriol, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (etykieta leku Karbamazepina, Ostrzeżenia i środki ostrożności)
- KarbidopaUmiarkowana
Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (etykieta leku Karbidopa, Interakcje z innymi lekami)
Antihypertensive drugs: May cause symptomatic postural hypotension. (etykieta leku Karbidopa + lewodopa, Interakcje z innymi lekami)
Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (etykieta leku Karbidopa + lewodopa + entakapon, Interakcje z innymi lekami)
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Kariprazyna, Ostrzeżenia i środki ostrożności)
Diuretics eplerenone The potential increase in plasma concentrations of eplerenone when coadministered with ketoconazole tablets may increase the risk of hyperkalemia and hypotension. (etykieta leku Ketokonazol, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Consider use of diuretics and/or albumin. (etykieta leku Klofarabina, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (etykieta leku Kolestyramina, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (etykieta leku Kwas zoledronowy, Ostrzeżenia i środki ostrożności)
Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (etykieta leku Kwetiapina, Ostrzeżenia i środki ostrożności)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Lanzoprazol, Ostrzeżenia i środki ostrożności)
Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (etykieta leku Lewomilnacypran, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Monitor serum sodium levels regularly in the elderly, in patients taking diuretics, and in other patients at risk of hyponatremia and/or SIADH while taking Linezolid injection. (etykieta leku Linezolid, Ostrzeżenia i środki ostrożności)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Concomitant Therapy Lithium In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity. (etykieta leku Metolazon, Ostrzeżenia)
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etykieta leku Lumateperon, Ostrzeżenia i środki ostrożności)
Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (etykieta leku Lurazydon, Ostrzeżenia i środki ostrożności)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Methenamine Efficacy may be decreased due to urinary alkalizing effect of metolazone. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (etykieta leku Milnacypran, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (etykieta leku Mirtazapina, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
- Niacyna (kwas nikotynowy)Umiarkowana
Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (etykieta leku Niacyna (kwas nikotynowy), Interakcje z innymi lekami)
Blood Pressure Lowering Drugs Nimodipine may increase the blood pressure lowering effect of concomitantly administered anti-hypertensives such as diuretics, beta-blockers, ACE inhibitors, angiotensin receptor blockers, other calcium channel blockers, α-adrenergic blockers, PDE5 inhibitors, and α-methyldopa. (etykieta leku Nimodypina, Interakcje z innymi lekami)
Antihypertensives: Possible additive hypotensive effects. (etykieta leku Nitrogliceryna, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
…of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (etykieta leku Olanzapina, Ostrzeżenia i środki ostrożności)
…and fluoxetine capsules should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (etykieta leku Olanzapina + fluoksetyna, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (etykieta leku Omeprazol, Ostrzeżenia i środki ostrożności)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (etykieta leku Omeprazol + wodorowęglan sodu, Ostrzeżenia i środki ostrożności)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (etykieta leku Paliperydon, Ostrzeżenia i środki ostrożności)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (etykieta leku Pantoprazol, Ostrzeżenia i środki ostrożności)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SNRIs and SSRIs. [see Use in Specific Populations ( 8.5 )]. (etykieta leku Paroksetyna, Ostrzeżenia i środki ostrożności)
The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (etykieta leku Parykalcytol, Ostrzeżenia i środki ostrożności)
- PazopanibUmiarkowana
Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (etykieta leku Pazopanib, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (etykieta leku Pentoksyfilina, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Prochlorperazyna, Środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (etykieta leku Rabeprazol, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (etykieta leku Riocyguat, Ostrzeżenia i środki ostrożności)
Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (etykieta leku Rysperydon, Ostrzeżenia i środki ostrożności)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Sertralina, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
- SorafenibUmiarkowana
Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (etykieta leku Sorafenib, Ostrzeżenia i środki ostrożności)
Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (etykieta leku Sotalol, Ostrzeżenia i środki ostrożności)
Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (etykieta leku Suksametonium, Ostrzeżenia i środki ostrożności)
Drug Interactions In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. (etykieta leku Sulfametoksazol + trimetoprim, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
- SunitynibUmiarkowana
Initiate and/or adjust antihypertensive therapy as appropriate. (etykieta leku Sunitynib, Ostrzeżenia i środki ostrożności)
Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (etykieta leku Syldenafil, Ostrzeżenia i środki ostrożności)
However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (etykieta leku Sylodosyna, Ostrzeżenia i środki ostrożności)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
• Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (etykieta leku Takrolimus, Ostrzeżenia i środki ostrożności)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (etykieta leku Testosteron, Ostrzeżenia i środki ostrożności)
Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. (etykieta leku Tobramycyna, Interakcje z innymi lekami)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
- TolwaptanUmiarkowana
Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (etykieta leku Tolwaptan, Ostrzeżenia i środki ostrożności)
Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (etykieta leku Toremifen, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (etykieta leku Metolazon, Interakcje z innymi lekami)
Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (etykieta leku Trazodon, Ostrzeżenia i środki ostrożności)
Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (etykieta leku Metolazon, Interakcje z innymi lekami)
Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Trifluoperazyna, Środki ostrożności)
Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (etykieta leku Wardenafil, Interakcje z innymi lekami)
Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (etykieta leku Metolazon, Interakcje z innymi lekami)
Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (etykieta leku Wenlafaksyna, Ostrzeżenia i środki ostrożności)
Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (etykieta leku Metolazon, Interakcje z innymi lekami)
Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Wilazodon, Ostrzeżenia i środki ostrożności)
Diuretyki tiazydowe zmniejszają wydalanie wapnia; w połączeniu z suplementami witaminy D i wapnia może to prowadzić do hiperkalcemii, zwłaszcza u osób starszych. (NIH Office of Dietary Supplements, Vitamin D)
Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (etykieta leku Wortioksetyna, Ostrzeżenia i środki ostrożności)
Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (etykieta leku Metolazon, Interakcje z innymi lekami)
Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (etykieta leku Zyprazydon, Ostrzeżenia i środki ostrożności)
Wzmianki o niewielkim znaczeniu (32)
- AmbrisentanNiewielka
Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (etykieta leku Ambrisentan, Ostrzeżenia i środki ostrożności)
These drugs include: aspirin, phenylbutazone, sulfonamides, indomethacin, thiazide diuretics, furosemide and ethacrynic acid. (etykieta leku Benzylopenicylina, Interakcje z innymi lekami)
Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (etykieta leku Bosentan, Ostrzeżenia i środki ostrożności)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
Diuretyki tiazydowe przy długotrwałym stosowaniu zwiększają utratę cynku z moczem. (NIH Office of Dietary Supplements, Zinc)
- DazatynibNiewielka
Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (etykieta leku Dazatynib, Ostrzeżenia i środki ostrożności)
If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (etykieta leku Dezogestrel + etynyloestradiol, Ostrzeżenia)
- DocetakselNiewielka
Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (etykieta leku Docetaksel, Ostrzeżenia i środki ostrożności)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
Hypokalemia and Hypomagnesemia with Potassium-Depleting Diuretics Hypokalemia or hypomagnesemia may occur with concomitant administration of potassium-depleting diuretics. (etykieta leku Dronedaron, Ostrzeżenia i środki ostrożności)
In addition to discontinuation of the drug, diuretic therapy may be required. (etykieta leku Estrogeny estryfikowane + metylotestosteron, Ostrzeżenia)
…clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives… (etykieta leku Finasteryd, Interakcje z innymi lekami)
Flecainide acetate has been used in a large number of patients receiving diuretics without apparent interaction. (etykieta leku Flekainid, Interakcje z innymi lekami)
- Glukonian wapniaNiewielka
Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (etykieta leku Glukonian wapnia, Interakcje z innymi lekami)
- IkatybantNiewielka
ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (etykieta leku Ikatybant, Interakcje z innymi lekami)
Weigh patients regularly and manage unexpected rapid weight gain by drug interruption and diuretics. (etykieta leku Imatynib, Ostrzeżenia i środki ostrożności)
- KortykotropinaNiewielka
Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (etykieta leku Kortykotropina, Interakcje z innymi lekami)
- MacytentanNiewielka
Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (etykieta leku Macytentan, Ostrzeżenia i środki ostrożności)
Długotrwałe stosowanie diuretyków pętlowych i tiazydowych zwiększa utratę magnezu z moczem. (NIH Office of Dietary Supplements, Magnesium)
In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (etykieta leku Meksyletyna, Interakcje z innymi lekami)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
In addition to discontinuation of the drug, diuretic therapy may be required. (etykieta leku Metylotestosteron, Ostrzeżenia)
The antihypertensive action of guanethidine and similar agents may be blocked. (etykieta leku Nortryptylina, Ostrzeżenia)
Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (etykieta leku Piperacylina + tazobaktam, Ostrzeżenia i środki ostrożności)
Diuretyki pętlowe i tiazydowe zwiększają utratę potasu; niekiedy razem z nimi przepisuje się suplementację. (NIH Office of Dietary Supplements, Potassium)
Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (etykieta leku Protryptylina, Ostrzeżenia)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, phenytoins, thiazide diuretics, and calcium channel blockers. (etykieta leku Terbinafina, Interakcje z innymi lekami)
Diuretyki tiazydowe zmniejszają wydalanie wapnia, więc duże spożycie wapnia może podnosić stężenie wapnia we krwi. (NIH Office of Dietary Supplements, Calcium)
Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (etykieta leku Metolazon, Ostrzeżenia)
Nie zgłoszono istotnej interakcji (2)
Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (etykieta leku Kwas pamidronowy, Interakcje z innymi lekami)
Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (etykieta leku Ropinirol, Interakcje z innymi lekami)
Sprawdź, jak Metolazon łączy się ze wszystkim, co przyjmujesz. Dodaj całą listę; wszystkie pary są sprawdzane jednocześnie.
Otwórz w wyszukiwarceTo nie jest porada medyczna. Stopień nasilenia odzwierciedla sformułowania etykiety, a nie indywidualne okoliczności. Oznaczenie „poważna” może dotyczyć połączenia stosowanego rutynowo pod nadzorem, a „niewielka” może mieć znaczenie przy dużych dawkach. Należy zapytać farmaceutę.