Interações de Metolazona

Metolazona (Zaroxolyn), diurético tiazídico, tem 423 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 103; moderadas: 286; leves: 32; casos em que uma bula relata não haver interação significativa: 2). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (103)

  • AcebutololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Ácido etacrínicodiurético de alçaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (bula de Alfacoriogonadotropina, Advertências)

  • Alisquirenoanti-hipertensivoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Amiloridadiurético poupador de potássioGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Anlodipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Anlodipino + atorvastatinabloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Anlodipino + benazeprilbloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Anlodipino + olmesartanabloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Anlodipino + valsartanabloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • AtenololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Atenolol + clortalidonabetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Azilsartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Benazeprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Benazepril + hidroclorotiazidainibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • BetaxololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Bicarbonato de sódioantiácidoGrave

    Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (bula de Bicarbonato de sódio, Contraindicações)

  • BisoprololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Bumetanidadiurético de alçaGrave

    WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. (bula de Bumetanida, Advertência em caixa preta)

  • Candesartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Candesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Captoprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • CarvedilolbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • CiclosporinaimunossupressorGrave

    Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (bula de Ciclosporina, Interações medicamentosas)

  • Citrato de potássiosuplemento de potássioGrave

    The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (bula de Citrato de potássio, Interações medicamentosas)

  • Clonidinaagonista alfa-adrenérgicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Clorotiazidadiurético tiazídicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Clortalidonadiurético tiazídicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • ClozapinaantipsicóticoGrave

    Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (bula de Clozapina, Advertência em caixa preta)

  • CONTRAINDICATIONS PROGLYCEM is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides (bula de Diazóxido, Contraindicações)

  • Diltiazembloqueador dos canais de cálcioGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • DofetilidaantiarrítmicoGrave

    In the DIAMOND trials, 1252 patients were treated with dofetilide and diuretics concomitantly, of whom 493 died compared to 508 deaths among the 1248 patients receiving placebo and diuretics. (bula de Dofetilida, Interações medicamentosas)

  • DoxazosinaalfabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Droperidolantagonista da dopaminaGrave

    Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (bula de Droperidol, Advertência em caixa preta)

  • Enalaprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Enalapril + hidroclorotiazidainibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Enalaprilateinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Eplerenonaantagonista da aldosteronaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Eptifibatidaantiagregante plaquetárioGrave

    …of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (bula de Eptifibatida, Contraindicações)

  • Espironolactonaantagonista da aldosteronaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Espironolactona + hidroclorotiazidaantagonista da aldosteronaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Felodipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • FenoxibenzaminaalfabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (bula de Folitropina, Advertências e precauções)

  • Fosinoprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Fosinopril + hidroclorotiazidainibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Furosemidadiurético de alçaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • GentamicinaaminoglicosídeoGrave

    The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (bula de Gentamicina, Advertência em caixa preta)

  • Guanfacinaagonista alfa-adrenérgicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • HidralazinavasodilatadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Hidroclorotiazidadiurético tiazídicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Indapamidadiurético tiazídicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Irbesartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Irbesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Avoid diuretics or laxatives in patients with diarrhea. (bula de Irinotecano, Advertências e precauções)

  • Isradipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Itraconazolantifúngico azólicoGrave

    Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (bula de Itraconazol, Interações medicamentosas)

  • LabetalolbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Lisinoprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Lisinopril + hidroclorotiazidainibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Lofexidinaagonista alfa-adrenérgicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Losartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Losartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Mecamilaminaanti-hipertensivoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Metildopaanti-hipertensivoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • MetoprololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • MinoxidilvasodilatadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Moexiprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • NadololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • NebivololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • NeomicinaaminoglicosídeoGrave

    The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (bula de Neomicina, Advertência em caixa preta)

  • Nicardipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Nifedipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Nisoldipinobloqueador dos canais de cálcio di-hidropiridínicoGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Nitroprusseto de sódiovasodilatadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Olmesartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Olmesartana + anlodipino + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Olmesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Perindoprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • PindololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • PrazosinaalfabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • PropranololbetabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Quinaprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Quinapril + hidroclorotiazidainibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Ramiprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Sacubitril + valsartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Tadalafilainibidor da PDE5Grave

    …coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (bula de Tadalafila, Advertências e precauções)

  • Telmisartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Telmisartana + anlodipinobloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Telmisartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • TerazosinaalfabloqueadorGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Tizanidinarelaxante muscularGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Torasemidadiurético de alçaGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Trandolaprilinibidor da ECAGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Trianterenodiurético poupador de potássioGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Triantereno + hidroclorotiazidadiurético poupador de potássioGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Trióxido de arsêniomedicamento que prolonga o intervalo QTGrave

    The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (bula de Trióxido de arsênio, Advertências e precauções)

  • Valsartanabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Valsartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Grave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

  • Verapamilbloqueador dos canais de cálcioGrave

    Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

Interações moderadas (286)

  • AcarboseantidiabéticoModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Acetazolamidainibidor da anidrase carbônicaModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Ácido acetilsalicílico + dipiridamolantiagregante plaquetárioModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Ácido mefenâmicoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Ácido zoledrônicobisfosfonatoModerada

    Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (bula de Ácido zoledrônico, Advertências e precauções)

  • ÁlcoolÁlcoolModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • AlfaepoetinaModerada

    Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (bula de Alfaepoetina, Advertências e precauções)

  • AlfuzosinaalfabloqueadorModerada

    Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (bula de Alfuzosina, Advertências e precauções)

  • Alogliptinainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Alogliptina + metforminainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Alopurinolinibidor da xantina oxidaseModerada

    Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (bula de Alopurinol, Advertências e precauções)

  • AmicacinaaminoglicosídeoModerada

    Ethacrynic Acid, Furosemide, Urea, or Mannitol Some diuretics can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. (bula de Amicacina, Interações medicamentosas)

  • AmiodaronaantiarrítmicoModerada

    Give special attention to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or in patients receiving concomitant diuretics and laxatives. (bula de Amiodarona, Advertências e precauções)

  • Anfepramona (dietilpropiona)estimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Anfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Anfetamina + dextroanfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • ApixabanaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Arformoterolagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • ArgatrobanaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • AripiprazolantipsicóticoModerada

    Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (bula de Aripiprazol, Interações medicamentosas)

  • Armodafinilaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Articaína + epinefrinaanestésico localModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • AsenapinaantipsicóticoModerada

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (bula de Asenapina, Advertências e precauções)

  • Atomoxetinainibidor da recaptação de noradrenalinaModerada

    Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (bula de Atomoxetina, Interações medicamentosas)

  • Avanafilainibidor da PDE5Moderada

    • Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (bula de Avanafila, Advertências e precauções)

  • Azelastina + fluticasonaanti-histamínicoModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • BalsalazidasalicilatoModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • BeclometasonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Beladona + ópioopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Benzfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • BetametasonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Bexagliflozinainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • BivalirudinaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • BortezomibeModerada

    Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (bula de Bortezomibe, Advertências e precauções)

  • BrexpiprazolantipsicóticoModerada

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Brexpiprazol, Advertências e precauções)

  • Brimonidinaagonista alfa-adrenérgicoModerada

    Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (bula de Brimonidina, Interações medicamentosas)

  • Brimonidina + timololagonista alfa-adrenérgicoModerada

    Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (bula de Brimonidina + timolol, Interações medicamentosas)

  • Bromocriptinaagonista da dopaminaModerada

    Use caution in patients taking antihypertensive medications. (bula de Bromocriptina, Advertências e precauções)

  • Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • BudesonidacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Budesonida + formoterolcorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Bupivacaína + epinefrinaanestésico localModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • BuprenorfinaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Butalbital + paracetamolbarbitúricoModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • ButorfanolopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Calcitriolanálogo da vitamina DModerada

    Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (bula de Calcitriol, Interações medicamentosas)

  • Canagliflozinainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • CarbamazepinaanticonvulsivanteModerada

    Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (bula de Carbamazepina, Advertências e precauções)

  • CarbidopaModerada

    Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (bula de Carbidopa, Interações medicamentosas)

  • Carbidopa + levodopamedicamento dopaminérgicoModerada

    Antihypertensive drugs: May cause symptomatic postural hypotension. (bula de Carbidopa + levodopa, Interações medicamentosas)

  • Carbidopa + levodopa + entacaponamedicamento dopaminérgicoModerada

    Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (bula de Carbidopa + levodopa + entacapona, Interações medicamentosas)

  • CariprazinaantipsicóticoModerada

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Cariprazina, Advertências e precauções)

  • CefepimacefalosporinaModerada

    Diuretics: Nephrotoxicity has been reported with concomitant administration of cephalosporins with potent diuretics such as furosemide. (bula de Cefepima, Interações medicamentosas)

  • CeftazidimacefalosporinaModerada

    Drug Interactions Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. (bula de Ceftazidima, Interações medicamentosas)

  • CelecoxibeAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Cetoconazolantifúngico azólicoModerada

    Diuretics eplerenone The potential increase in plasma concentrations of eplerenone when coadministered with ketoconazole tablets may increase the risk of hyperkalemia and hypotension. (bula de Cetoconazol, Interações medicamentosas)

  • CetoprofenoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • CetorolacoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • CiclesonidacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Ciclobenzaprinarelaxante muscularModerada

    …concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (bula de Ciclobenzaprina, Interações medicamentosas)

  • CiclofosfamidaimunossupressorModerada

    …inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity… (bula de Ciclofosfamida, Interações medicamentosas)

  • Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (bula de Ciclossilicato de zircônio sódico, Advertências e precauções)

  • CitalopramISRSModerada

    Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Citalopram, Advertências e precauções)

  • ClobetasolcorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • ClofarabinaantimetabólitoModerada

    Consider use of diuretics and/or albumin. (bula de Clofarabina, Advertências e precauções)

  • Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (bula de Cloreto de cálcio, Interações medicamentosas)

  • ClorpromazinaantipsicóticoModerada

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Clorpromazina, Precauções)

  • CodeínaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Colestiraminasequestrante de ácidos biliaresModerada

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (bula de Colestiramina, Interações medicamentosas)

  • DabigatranaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Dapagliflozinainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Dapagliflozina + metforminainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • DeflazacortecorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Desipraminaantidepressivo tricíclicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (bula de Desipramina, Advertências)

  • …Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (bula de Desmopressina, Interações medicamentosas)

  • DesonidacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • DesvenlafaxinaIRSNModerada

    Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (bula de Desvenlafaxina, Advertências e precauções)

  • DexametasonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Dexlansoprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Dexlansoprazol, Advertências e precauções)

  • Dexmetilfenidatoestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Dextroanfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • DiclofenacoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Diclorfenamidainibidor da anidrase carbônicaModerada

    Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (bula de Diclorfenamida, Interações medicamentosas)

  • DiflunisalAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Digoxinaglicosídeo digitálicoModerada

    Digitalis Glycosides Diuretic-induced hypokalemia can increase the sensitivity of the myocardium to digitalis. (bula de Metolazona, Interações medicamentosas)

  • DobutaminasimpaticomiméticoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Doxercalciferolanálogo da vitamina DModerada

    Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (bula de Doxercalciferol, Advertências e precauções)

  • Drospirenona + etinilestradiolanticoncepcional oralModerada

    Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (bula de Drospirenona + etinilestradiol, Advertências e precauções)

  • DroxidopasimpaticomiméticoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Dulaglutidaagonista do receptor de GLP-1Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • DuloxetinaIRSNModerada

    The risk of BP decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see Drug Interactions ( 7.1 )] and in patients taking duloxetine delayed-release capsules at doses above 60 mg daily. (bula de Duloxetina, Advertências e precauções)

  • EdoxabanaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • EfedrinasimpaticomiméticoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • EluxadolinaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Empagliflozinainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Empagliflozina + metforminainibidor do SGLT2Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • EnoxaparinaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Epinefrina (adrenalina)simpaticomiméticoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Epoprostenolanálogo de prostaglandinaModerada

    Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (bula de Epoprostenol, Interações medicamentosas)

  • Ergotamina + cafeínaalcaloide do ergotModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • EscitalopramISRSModerada

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (bula de Escitalopram, Advertências e precauções)

  • EsmololbetabloqueadorModerada

    Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (bula de Esmolol, Interações medicamentosas)

  • Esomeprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Esomeprazol, Advertências e precauções)

  • EtodolacoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Exenatidaagonista do receptor de GLP-1Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Fendimetrazinaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Fenelzinainibidor da MAOModerada

    …hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine Phenelzine sulfate should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result. (bula de Fenelzina, Advertências)

  • FenilefrinadescongestionanteModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • FenobarbitalbarbitúricoModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • FenoprofenoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • FentanilaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Fenterminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Fentermina + topiramatoestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Fluconazolantifúngico azólicoModerada

    An effect of this magnitude should not necessitate a change in the fluconazole dose regimen in subjects receiving concomitant diuretics. (bula de Fluconazol, Interações medicamentosas)

  • FludrocortisonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • FlunisolidacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • FluocinonidacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • FluoxetinaISRSModerada

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (bula de Fluoxetina, Advertências e precauções)

  • FlurbiprofenoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • FluticasonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Fluticasona + salmeterolcorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • FluvoxaminaISRSModerada

    Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (bula de Fluvoxamina, Advertências e precauções)

  • FondaparinuxanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Formoterolagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • FoscarneteantiviralModerada

    When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (bula de Foscarnete, Interações medicamentosas)

  • GlibenclamidasulfonilureiaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Glibenclamida + metforminasulfonilureiaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • GlimepiridasulfonilureiaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • GlipizidasulfonilureiaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Glipizida + metforminasulfonilureiaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • HalobetasolcorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • HaloperidolantipsicóticoModerada

    Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (bula de Haloperidol, Interações medicamentosas)

  • HeparinaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • HidrocodonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • HidrocortisonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • HidromorfonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • IbuprofenoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • IloperidonaantipsicóticoModerada

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Iloperidona, Advertências e precauções)

  • Imipraminaantidepressivo tricíclicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (bula de Imipramina, Advertências)

  • IndometacinaAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Insulina asparteinsulinaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Insulina degludecainsulinaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Insulina detemirinsulinaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Insulina glarginainsulinaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Insulina lisproinsulinaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (bula de Iodeto de potássio, Interações medicamentosas)

  • Ipratrópio + salbutamolanticolinérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Isoprenalina (isoproterenol)agonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Lansoprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Lansoprazol, Advertências e precauções)

  • LevomilnacipranaIRSNModerada

    Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (bula de Levomilnaciprana, Advertências e precauções)

  • LevorfanolopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Levossalbutamolagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Lidocaína + epinefrinaanestésico localModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Linagliptinainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Linagliptina + metforminainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • LinezolidaantibióticoModerada

    Monitor serum sodium levels regularly in the elderly, in patients taking diuretics, and in other patients at risk of hyponatremia and/or SIADH while taking Linezolid injection. (bula de Linezolida, Advertências e precauções)

  • Liraglutidaagonista do receptor de GLP-1Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Lisdexanfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Lítiomedicamento serotoninérgicoModerada

    Concomitant Therapy Lithium In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity. (bula de Metolazona, Advertências)

  • LumateperonaantipsicóticoModerada

    Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (bula de Lumateperona, Advertências e precauções)

  • LurasidonaantipsicóticoModerada

    Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (bula de Lurasidona, Advertências e precauções)

  • MeloxicamAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • MesalazinasalicilatoModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • MetadonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Metanfetaminaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • MetenaminaantibióticoModerada

    Methenamine Efficacy may be decreased due to urinary alkalizing effect of metolazone. (bula de Metolazona, Interações medicamentosas)

  • MetforminabiguanidaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Metilfenidatoestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • MetilprednisolonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • MetoexitalbarbitúricoModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Midodrinaagonista alfa-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • MiglitolantidiabéticoModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • MilnacipranaIRSNModerada

    Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (bula de Milnaciprana, Advertências e precauções)

  • Mirabegronaagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • MirtazapinaantidepressivoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (bula de Mirtazapina, Advertências e precauções)

  • Modafinilaestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • MometasonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • MorfinaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • NabumetonaAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • NalbufinaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • NaproxenoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • NateglinidameglitinidaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (bula de Niacina (ácido nicotínico), Interações medicamentosas)

  • Nimodipinobloqueador dos canais de cálcio di-hidropiridínicoModerada

    Blood Pressure Lowering Drugs Nimodipine may increase the blood pressure lowering effect of concomitantly administered anti-hypertensives such as diuretics, beta-blockers, ACE inhibitors, angiotensin receptor blockers, other calcium channel blockers, α-adrenergic blockers, PDE5 inhibitors, and α-methyldopa. (bula de Nimodipino, Interações medicamentosas)

  • NitroglicerinanitratoModerada

    Antihypertensives: Possible additive hypotensive effects. (bula de Nitroglicerina, Interações medicamentosas)

  • OlanzapinaantipsicóticoModerada

    …of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (bula de Olanzapina, Advertências e precauções)

  • Olanzapina + fluoxetinaantipsicóticoModerada

    …and fluoxetine capsules should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (bula de Olanzapina + fluoxetina, Advertências e precauções)

  • OliceridinaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Olopatadina + mometasonaanti-histamínicoModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Omeprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (bula de Omeprazol, Advertências e precauções)

  • Omeprazol + bicarbonato de sódioinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (bula de Omeprazol + bicarbonato de sódio, Advertências e precauções)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • OxaprozinaAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • OxicodonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • OximetazolinadescongestionanteModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • OximorfonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • PaliperidonaantipsicóticoModerada

    Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (bula de Paliperidona, Advertências e precauções)

  • Pantoprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (bula de Pantoprazol, Advertências e precauções)

  • Paracetamol + codeínaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Paricalcitolanálogo da vitamina DModerada

    The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (bula de Paricalcitol, Advertências e precauções)

  • ParoxetinaISRSModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SNRIs and SSRIs. [see Use in Specific Populations ( 8.5 )]. (bula de Paroxetina, Advertências e precauções)

  • PazopanibeModerada

    Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (bula de Pazopanibe, Advertências e precauções)

  • Pentazocina + naloxonaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • PentoxifilinametilxantinaModerada

    Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (bula de Pentoxifilina, Interações medicamentosas)

  • Petidina (meperidina)opioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • PioglitazonatiazolidinedionaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Pioglitazona + glimepiridatiazolidinedionaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Pioglitazona + metforminatiazolidinedionaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • PiroxicamAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • PrednisolonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • PrednisonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • Prilocaína + epinefrinaanestésico localModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • PrimidonaanticonvulsivanteModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • ProclorperazinaantipsicóticoModerada

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Proclorperazina, Precauções)

  • Prometazina + codeínaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • PseudoefedrinadescongestionanteModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • QuetiapinaantipsicóticoModerada

    Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (bula de Quetiapina, Advertências e precauções)

  • QuinidinaantiarrítmicoModerada

    Drugs that alkalinize the urine ( carbonic-anhydrase inhibitors, sodium bicarbonate, thiazide diuretics ) reduce renal elimination of quinidine. (bula de Quinidina, Interações medicamentosas)

  • Rabeprazolinibidor da bomba de prótonsModerada

    For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (bula de Rabeprazol, Advertências e precauções)

  • RemifentanilaopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • RepaglinidameglitinidaModerada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • RiociguatevasodilatadorModerada

    Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (bula de Riociguate, Advertências e precauções)

  • RisperidonaantipsicóticoModerada

    Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (bula de Risperidona, Advertências e precauções)

  • RivaroxabanaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • Salbutamolagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Salmeterolagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • SalsalatoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Saxagliptinainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Saxagliptina + metforminainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Semaglutidaagonista do receptor de GLP-1Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • SertralinaISRSModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Sildenafilainibidor da PDE5Moderada

    Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (bula de Sildenafila, Advertências e precauções)

  • SilodosinaalfabloqueadorModerada

    However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (bula de Silodosina, Advertências e precauções)

  • Sitagliptinainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Sitagliptina + metforminainibidor da DPP-4Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • Solriamfetolestimulante do SNCModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • SorafenibeModerada

    Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (bula de Sorafenibe, Advertências e precauções)

  • SotalolbetabloqueadorModerada

    Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (bula de Sotalol, Advertências e precauções)

  • Subsalicilato de bismutosalicilatoModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Drug Interactions In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. (bula de Sulfametoxazol + trimetoprima, Interações medicamentosas)

  • SulfassalazinasulfonamidaModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • SulindacoAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • Sumatriptana + naproxenotriptanoModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • SunitinibeModerada

    Initiate and/or adjust antihypertensive therapy as appropriate. (bula de Sunitinibe, Advertências e precauções)

  • Suxametônio (succinilcolina)bloqueador neuromuscularModerada

    Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (bula de Suxametônio (succinilcolina), Advertências e precauções)

  • TacrolimoimunossupressorModerada

    • Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (bula de Tacrolimo, Advertências e precauções)

  • TapentadolopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Terbutalinaagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • TestosteronaandrogênioModerada

    In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (bula de Testosterona, Advertências e precauções)

  • Tirzepatidaagonista do receptor de GLP-1Moderada

    Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (bula de Metolazona, Interações medicamentosas)

  • TobramicinaaminoglicosídeoModerada

    Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. (bula de Tobramicina, Interações medicamentosas)

  • TolmetinaAINEModerada

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (bula de Metolazona, Interações medicamentosas)

  • TolvaptanaModerada

    Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (bula de Tolvaptana, Advertências e precauções)

  • Toremifenomodulador seletivo do receptor de estrogênioModerada

    Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (bula de Toremifeno, Interações medicamentosas)

  • TramadolopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • Tramadol + paracetamolopioideModerada

    Alcohol, Barbiturates, And Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. (bula de Metolazona, Interações medicamentosas)

  • TrazodonaantidepressivoModerada

    Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (bula de Trazodona, Advertências e precauções)

  • TriancinolonacorticosteroideModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • TrifluoperazinaantipsicóticoModerada

    Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Trifluoperazina, Precauções)

  • Umeclidínio + vilanterolanticolinérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • Vardenafilainibidor da PDE5Moderada

    Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (bula de Vardenafila, Interações medicamentosas)

  • VarfarinaanticoagulanteModerada

    Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (bula de Metolazona, Interações medicamentosas)

  • VenlafaxinaIRSNModerada

    Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (bula de Venlafaxina, Advertências e precauções)

  • Vibegronaagonista beta-adrenérgicoModerada

    Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. (bula de Metolazona, Interações medicamentosas)

  • VilazodonaISRSModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (bula de Vilazodona, Advertências e precauções)

  • Vitamina DVitaminas e mineraisModerada

    Os diuréticos tiazídicos reduzem a excreção de cálcio; combinado com suplementos de vitamina D e de cálcio, isso pode levar a hipercalcemia, especialmente em idosos. (NIH Office of Dietary Supplements, Vitamin D)

  • VortioxetinaantidepressivoModerada

    Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (bula de Vortioxetina, Advertências e precauções)

  • ZiprasidonaantipsicóticoModerada

    Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (bula de Ziprasidona, Advertências e precauções)

Menções leves (32)

  • Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (bula de Ambrisentana, Advertências e precauções)

  • Benzilpenicilina (penicilina G)antibiótico da classe das penicilinasLeve

    These drugs include: aspirin, phenylbutazone, sulfonamides, indomethacin, thiazide diuretics, furosemide and ethacrynic acid. (bula de Benzilpenicilina (penicilina G), Interações medicamentosas)

  • Bosentanaindutor da CYP3A4Leve

    Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (bula de Bosentana, Advertências e precauções)

  • Brinzolamidainibidor da anidrase carbônicaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • CálcioVitaminas e mineraisLeve

    Os diuréticos tiazídicos reduzem a excreção de cálcio, de modo que um consumo alto de cálcio pode elevar o cálcio no sangue. (NIH Office of Dietary Supplements, Calcium)

  • Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (bula de Corticotropina, Interações medicamentosas)

  • Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (bula de Dasatinibe, Advertências e precauções)

  • Desogestrel + etinilestradiolanticoncepcional oralLeve

    If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (bula de Desogestrel + etinilestradiol, Advertências)

  • Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (bula de Docetaxel, Advertências e precauções)

  • Dorzolamidainibidor da anidrase carbônicaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • Dorzolamida + timololinibidor da anidrase carbônicaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • DronedaronaantiarrítmicoLeve

    Hypokalemia and Hypomagnesemia with Potassium-Depleting Diuretics Hypokalemia or hypomagnesemia may occur with concomitant administration of potassium-depleting diuretics. (bula de Dronedarona, Advertências e precauções)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (bula de Estrogênios esterificados + metiltestosterona, Advertências)

  • Finasteridainibidor da 5-alfa-redutaseLeve

    …clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives… (bula de Finasterida, Interações medicamentosas)

  • FlecainidaantiarrítmicoLeve

    Flecainide acetate has been used in a large number of patients receiving diuretics without apparent interaction. (bula de Flecainida, Interações medicamentosas)

  • Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (bula de Gliconato de cálcio, Interações medicamentosas)

  • ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (bula de Icatibanto, Interações medicamentosas)

  • Imatinibeinibidor da CYP3A4Leve

    Weigh patients regularly and manage unexpected rapid weight gain by drug interruption and diuretics. (bula de Imatinibe, Advertências e precauções)

  • Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (bula de Macitentana, Advertências e precauções)

  • MagnésioVitaminas e mineraisLeve

    O uso prolongado de diuréticos de alça e tiazídicos aumenta a perda de magnésio na urina. (NIH Office of Dietary Supplements, Magnesium)

  • Metazolamidainibidor da anidrase carbônicaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • MetiltestosteronaandrogênioLeve

    In addition to discontinuation of the drug, diuretic therapy may be required. (bula de Metiltestosterona, Advertências)

  • MexiletinaantiarrítmicoLeve

    In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (bula de Mexiletina, Interações medicamentosas)

  • Nortriptilinaantidepressivo tricíclicoLeve

    The antihypertensive action of guanethidine and similar agents may be blocked. (bula de Nortriptilina, Advertências)

  • Piperacilina + tazobactamantibiótico da classe das penicilinasLeve

    Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics. (bula de Piperacilina + tazobactam, Advertências e precauções)

  • PotássioVitaminas e mineraisLeve

    Os diuréticos de alça e tiazídicos aumentam a perda de potássio; a suplementação às vezes é prescrita junto com eles. (NIH Office of Dietary Supplements, Potassium)

  • Protriptilinaantidepressivo tricíclicoLeve

    Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (bula de Protriptilina, Advertências)

  • SulfadiazinasulfonamidaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • Sulfadiazina de pratasulfonamidaLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

  • TerbinafinaantifúngicoLeve

    There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, phenytoins, thiazide diuretics, and calcium channel blockers. (bula de Terbinafina, Interações medicamentosas)

  • ZincoVitaminas e mineraisLeve

    Os diuréticos tiazídicos aumentam a perda de zinco na urina com o uso prolongado. (NIH Office of Dietary Supplements, Zinc)

  • ZonisamidaanticonvulsivanteLeve

    Cross-Allergy Cross-allergy may occur when metolazone tablets, USP, are given to patients known to be allergic to sulfonamide-derived drugs, thiazides, or quinethazone. (bula de Metolazona, Advertências)

Nenhuma interação significativa relatada (2)

  • PamidronatobisfosfonatoSem interação

    Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (bula de Pamidronato, Interações medicamentosas)

  • Ropinirolagonista da dopaminaSem interação

    Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (bula de Ropinirol, Interações medicamentosas)

Verifique Metolazona com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

Abrir no verificador

Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.