Probenecyd + kolchicyna: interakcje

Co-administration with probenecid is not recommended. (etykieta leku Amoksycylina + kwas klawulanowy, Interakcje z innymi lekami)

Antigout: colchicine ↑ colchicine The coadministration of REYATAZ with colchicine in patients with renal or hepatic impairment is not recommended. (etykieta leku Atazanawir, Interakcje z innymi lekami)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Thus, probenecid should not be administered concurrently with bumetanide. (etykieta leku Bumetanid, Interakcje z innymi lekami)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Co-administration of probenecid with cephalexin for oral suspension is not recommended. (etykieta leku Cefaleksyna, Interakcje z innymi lekami)

Co-administration of probenecid with Cefazolin for Injection is not recommended. (etykieta leku Cefazolina, Interakcje z innymi lekami)

Administration of cefotaxime in excess of 6 grams/day should be avoided in patients receiving probenecid (see CLINICAL PHARMACOLOGY, Drug Interactions ). (etykieta leku Cefotaksym, Interakcje z innymi lekami)

Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (etykieta leku Cefuroksym, Interakcje z innymi lekami)

TO REDUCE POSSIBLE NEPHROTOXICITY, INTRAVENOUS PREHYDRATION WITH NORMAL SALINE AND ADMINISTRATION OF PROBENECID MUST BE USED WITH EACH CIDOFOVIR INFUSION. (etykieta leku Cydofowir, Ostrzeżenie w ramce)

Alpha 1-adrenoreceptor antagonist: alfuzosin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine Herbal product: St. (etykieta leku Darunawir, Przeciwwskazania)

Alpha 1-adrenoreceptor antagonist: alfuzosin Anticonvulsants: carbamazepine, phenobarbital, phenytoin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine… (etykieta leku Darunawir + kobicystat, Przeciwwskazania)

Effect of Other Drugs on FERRIPROX UDP-Glucuronosyltransferases (UGT) Avoid use of UGT1A6 inhibitors (e.g., diclofenac, probenecid, or silymarin (milk thistle)) with FERRIPROX [ see Dosage and Administration ( 2.2 ) , Adverse Reactions ( 6.1 ), Clinical Pharmacology ( 12.3 ) ] . (etykieta leku Deferypron, Interakcje z innymi lekami)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Anti-gout: colchicine ↑ colchicine GENVOYA is not recommended to be coadministered with colchicine to patients with renal or hepatic impairment. (etykieta leku Elwitegrawir + kobicystat + emtrycytabina + tenofowir, Interakcje z innymi lekami)

Co-administration with probenecid inhibits the renal excretion of ertapenem and is therefore not recommended. (etykieta leku Ertapenem, Interakcje z innymi lekami)

Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN. (etykieta leku Imipenem + cylastatyna, Interakcje z innymi lekami)

Co-administration with colchicine, fesoterodine and solifenacin is contraindicated in subjects with varying degrees of renal or hepatic impairment. (etykieta leku Itrakonazol, Ostrzeżenie w ramce)

…contraindicated with ketoconazole tablets: methadone, disopyramide, dronedarone, ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine, methylergometrine, irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine (see PRECAUTIONS: Drug Interactions ). (etykieta leku Ketokonazol, Przeciwwskazania)

Therefore, the combination of ketoprofen and probenecid is not recommended. (etykieta leku Ketoprofen, Ostrzeżenia i środki ostrożności)

The concomitant use of ketorolac tromethamine and probenecid is contraindicated. (etykieta leku Ketorolak, Przeciwwskazania)

Colchicine in renal or hepatic impairment ( 4.4 ) (etykieta leku Klarytromycyna, Przeciwwskazania)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Alpha 1- Adrenoreceptor Antagonist: alfuzosin Antianginal: ranolazine Antiarrhythmic: dronedarone Anti-gout: colchicine Antipsychotics: lurasidone, pimozide Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine GI Motility Agent: cisapride Hepatitis C direct acting antiviral: elbasvir/grazoprevir HMG-CoA Reductase Inhibitors: lovastatin, simvastatin… (etykieta leku Lopinawir + rytonawir, Przeciwwskazania)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Co-administration of Meropenem for injection with probenecid inhibits renal excretion of meropenem and is therefore not recommended ( 7.1 ) (etykieta leku Meropenem, Interakcje z innymi lekami)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

…Interactions (7.3) ] : • Alpha 1-adrenoreceptor antagonist: alfuzosin • Antianginal: ranolazine • Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine • Anti-gout: colchicine (in patients with renal and/or hepatic impairment [see Table 2 , Drug Interactions (7.3)] ) • Antipsychotics: lurasidone, pimozide • Benign prostatic hyperplasia agents:… (etykieta leku Nirmatrelwir + rytonawir, Przeciwwskazania)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection and Sodium Chloride Injection unless the benefit outweighs the risk. (etykieta leku Piperacylina + tazobaktam, Interakcje z innymi lekami)

Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs. (etykieta leku Pralatreksat, Interakcje z innymi lekami)

…Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors:… (etykieta leku Rytonawir, Przeciwwskazania)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Drug Interactions Coadministration of probenecid with intravenous acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve. (etykieta leku Acyklowir, Interakcje z innymi lekami)

In order to prevent gout flares when treatment with allopurinol tablets is initiated, concurrent prophylactic treatment with colchicine or an anti-inflammatory agent is recommended [ see Dosage and Administration (2.2) ]. (etykieta leku Allopurynol, Ostrzeżenia i środki ostrożności)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (> 1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (etykieta leku Amlodypina + atorwastatyna, Ostrzeżenia i środki ostrożności)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (>1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (etykieta leku Atorwastatyna, Ostrzeżenia i środki ostrożności)

Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised. (etykieta leku Azytromycyna, Interakcje z innymi lekami)

In patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) the recommended dosage should be reduced. (etykieta leku Baricytynib, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (etykieta leku Bromokryptyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

…Immunosuppressives Other Drugs ciprofloxacin melphalan amphotericin B azapropazon cimetidine tacrolimus fibric acid derivatives (e.g., bezafibrate, fenofibrate) gentamicin ketoconazole colchicine ranitidine methotrexate tobramycin diclofenac trimethoprim with sulfamethoxazole naproxen vancomycin sulindac During the concomitant use of a drug that may exhibit additive… (etykieta leku Cyklosporyna, Interakcje z innymi lekami)

Decrease ciprofloxacin absorption, resulting in lower serum and urine levels Probenecid Use with caution (interferes with renal tubular secretion of ciprofloxacin and increases ciprofloxacin serum levels) Potentiation of ciprofloxacin toxicity may occur. (etykieta leku Cyprofloksacyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; and hypotension with calcium channel blockers metabolized by CYP3A4 (for example, verapamil, amlodipine, diltiazem) (see PRECAUTIONS, Drug Interactions ). (etykieta leku Erytromycyna, Ostrzeżenia)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (etykieta leku Ezetymib + symwastatyna, Ostrzeżenia i środki ostrożności)

Probenecid: May increase penciclovir levels. (etykieta leku Famcyklowir, Interakcje z innymi lekami)

In order to prevent gout flares when ULORIC is initiated, concurrent prophylactic treatment with an NSAID or colchicine is recommended [see Dosage and Administration (2.4) ]. (etykieta leku Febuksostat, Ostrzeżenia i środki ostrożności)

Consider whether the benefit of using colchicine concomitantly with fenofibrate outweighs the increased risk of myopathy [see Drug Interactions (7) ]. (etykieta leku Fenofibrat, Ostrzeżenia i środki ostrożności)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid : May inhibit renal excretion of metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine; monitor for potential neurotoxicity. (etykieta leku Fenylomaślan sodu, Interakcje z innymi lekami)

When used concomitantly with fluvastatin sodium extended-release tablets, lipid modifying doses (≥ 1 g/day) of niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1 )] . (etykieta leku Fluwastatyna, Ostrzeżenia i środki ostrożności)

Fosamprenavir calcium/ritonavir and coadministration of colchicine: Treatment of gout flares: 0.6 mg (1 tablet) x 1 dose, followed by 0.3 mg (half tablet) 1 hour later. (etykieta leku Fosamprenawir, Interakcje z innymi lekami)

Probenecid ↑Ganciclovir Ganciclovir for Injection dose may need to be reduced. (etykieta leku Gancyklowir, Interakcje z innymi lekami)

(G) Colchicine Myopathy, including rhabdomyolysis, has been reported with chronic administration of colchicine at therapeutic doses. (etykieta leku Gemfibrozyl, Interakcje z innymi lekami)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Probenecid Clinical Impact: When indomethacin is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. (etykieta leku Indometacyna, Interakcje z innymi lekami)

Monitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )] . (etykieta leku Kabozantynib, Interakcje z innymi lekami)

In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Consider whether the benefit of using colchicine concomitantly with fenofibric acid delayed-release capsules outweighs the increased risk of myopathy [see Drug Interactions (7) ] . (etykieta leku Kwas fenofibrowy, Ostrzeżenia i środki ostrożności)

Renal clearance of ucb L057 in the presence of probenecid decreased 60%, probably related to competitive inhibition of tubular secretion of ucb L057. (etykieta leku Lewetyracetam, Interakcje z innymi lekami)

However, these changes do not warrant dosage adjustment for Levofloxacin in 5% Dextrose Injection when probenecid or cimetidine is co-administered. (etykieta leku Lewofloksacyna, Interakcje z innymi lekami)

Coadministration of lomitapide with P-gp substrates (such as aliskiren, ambrisentan, colchicine, dabigatran etexilate, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan) may increase the absorption of P-gp substrates. (etykieta leku Lomitapid, Interakcje z innymi lekami)

Colchicine: Cases of myopathy, including rhabdomyolysis, have been reported with lovastatin coadministered with colchicine, and caution should be exercised when prescribing lovastatin with colchicine (see PRECAUTIONS , Drug Interactions ). (etykieta leku Lowastatyna, Ostrzeżenia)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid increases plasma concentrations of methotrexate in both animals and humans. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (etykieta leku Naproksen, Interakcje z innymi lekami)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

The following drugs when used concomitantly with LIVALO may also increase the risk of myopathy and rhabdomyolysis: lipid-modifying dosages of niacin (>1grams/day), fibrates, and colchicine [see Drug Interactions (7) ]. (etykieta leku Pitawastatyna, Ostrzeżenia i środki ostrożności)

The following drugs when used concomitantly with pravastatin sodium may also increase the risk of myopathy and rhabdomyolysis: niacin, fibrates, and colchicine [see Drug Interactions ( 7 )]. (etykieta leku Prawastatyna, Ostrzeżenia i środki ostrożności)

Niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1) ]. (etykieta leku Rozuwastatyna, Ostrzeżenia i środki ostrożności)

Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of rifampin toxicities. (etykieta leku Ryfampicyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (etykieta leku Sumatryptan + naproksen, Interakcje z innymi lekami)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (etykieta leku Symwastatyna, Ostrzeżenia i środki ostrożności)

Organic Anion Drugs Coadministration of organic anion drugs (e.g., probenecid) that undergo significant renal tubular secretion have the potential to reduce secretion of torsemide into the proximal tubule and thereby decreases the diuretic activity of torsemide. (etykieta leku Torasemid, Interakcje z innymi lekami)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (etykieta leku Probenecyd + kolchicyna, Ostrzeżenia)

Didanosine ↔ Ganciclovir ↑ Didanosine Patients should be closely monitored for didanosine toxicity (e.g., pancreatitis) Probenecid ↑ Ganciclovir Valganciclovir hydrochloride dose may need to be reduced. (etykieta leku Walgancyklowir, Interakcje z innymi lekami)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin, and chloramphenicol). (etykieta leku Entakapon, Środki ostrożności)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA. (etykieta leku Fenylomaślan glicerolu, Interakcje z innymi lekami)

Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate. (etykieta leku Fenylooctan sodu + benzoesan sodu, Interakcje z innymi lekami)

Probenecid Probenecid is a blocker of renal tubular secretion. (etykieta leku Gabapentyna, Interakcje z innymi lekami)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol). (etykieta leku Karbidopa + lewodopa + entakapon, Interakcje z innymi lekami)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Uricosuric Drugs Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. (etykieta leku Nitrofurantoina, Interakcje z innymi lekami)

Probenecid The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. (etykieta leku Ofloksacyna, Interakcje z innymi lekami)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

The uricosuric action of probenecid is also antagonized by pyrazinamide. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

…hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol (see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories–propoxyphene, aspirin, indomethacin,… (etykieta leku Prazosyna, Interakcje z innymi lekami)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (etykieta leku Probenecyd + kolchicyna, Interakcje z innymi lekami)

Probenecid does not affect renal tubular transport of gentamicin. (etykieta leku Gentamycyna, Interakcje z innymi lekami)

Examples Acyclovir, ganciclovir, probenecid, valacyclovir, valganciclovir Combination Oral Contraceptives Clinical Impact Concomitant use with mycophenolate mofetil decreased the systemic exposure to levonorgestrel, but did not affect the systemic exposure to ethinylestradiol [see Clinical Pharmacology ( 12.3 )], which may result in reduced combination oral contraceptive… (etykieta leku Mykofenolan, Interakcje z innymi lekami)