Wechselwirkungen von Probenecid und Colchicin

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Co-administration with probenecid is not recommended. (Fachinformation zu Amoxicillin und Clavulansäure, Arzneimittelwechselwirkungen)

Antigout: colchicine ↑ colchicine The coadministration of REYATAZ with colchicine in patients with renal or hepatic impairment is not recommended. (Fachinformation zu Atazanavir, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Thus, probenecid should not be administered concurrently with bumetanide. (Fachinformation zu Bumetanid, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Co-administration of probenecid with cephalexin for oral suspension is not recommended. (Fachinformation zu Cefalexin, Arzneimittelwechselwirkungen)

Co-administration of probenecid with Cefazolin for Injection is not recommended. (Fachinformation zu Cefazolin, Arzneimittelwechselwirkungen)

Administration of cefotaxime in excess of 6 grams/day should be avoided in patients receiving probenecid (see CLINICAL PHARMACOLOGY, Drug Interactions ). (Fachinformation zu Cefotaxim, Arzneimittelwechselwirkungen)

Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (Fachinformation zu Cefuroxim, Arzneimittelwechselwirkungen)

TO REDUCE POSSIBLE NEPHROTOXICITY, INTRAVENOUS PREHYDRATION WITH NORMAL SALINE AND ADMINISTRATION OF PROBENECID MUST BE USED WITH EACH CIDOFOVIR INFUSION. (Fachinformation zu Cidofovir, Boxed Warning (umrahmter Warnhinweis))

Colchicine in renal or hepatic impairment ( 4.4 ) (Fachinformation zu Clarithromycin, Gegenanzeigen)

Alpha 1-adrenoreceptor antagonist: alfuzosin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine Herbal product: St. (Fachinformation zu Darunavir, Gegenanzeigen)

Alpha 1-adrenoreceptor antagonist: alfuzosin Anticonvulsants: carbamazepine, phenobarbital, phenytoin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine… (Fachinformation zu Darunavir und Cobicistat, Gegenanzeigen)

Effect of Other Drugs on FERRIPROX UDP-Glucuronosyltransferases (UGT) Avoid use of UGT1A6 inhibitors (e.g., diclofenac, probenecid, or silymarin (milk thistle)) with FERRIPROX [ see Dosage and Administration ( 2.2 ) , Adverse Reactions ( 6.1 ), Clinical Pharmacology ( 12.3 ) ] . (Fachinformation zu Deferipron, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Anti-gout: colchicine ↑ colchicine GENVOYA is not recommended to be coadministered with colchicine to patients with renal or hepatic impairment. (Fachinformation zu Elvitegravir, Cobicistat, Emtricitabin und Tenofovir, Arzneimittelwechselwirkungen)

Co-administration with probenecid inhibits the renal excretion of ertapenem and is therefore not recommended. (Fachinformation zu Ertapenem, Arzneimittelwechselwirkungen)

Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN. (Fachinformation zu Imipenem und Cilastatin, Arzneimittelwechselwirkungen)

Co-administration with colchicine, fesoterodine and solifenacin is contraindicated in subjects with varying degrees of renal or hepatic impairment. (Fachinformation zu Itraconazol, Boxed Warning (umrahmter Warnhinweis))

…contraindicated with ketoconazole tablets: methadone, disopyramide, dronedarone, ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine, methylergometrine, irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine (see PRECAUTIONS: Drug Interactions ). (Fachinformation zu Ketoconazol, Gegenanzeigen)

Therefore, the combination of ketoprofen and probenecid is not recommended. (Fachinformation zu Ketoprofen, Warnhinweise und Vorsichtsmaßnahmen)

The concomitant use of ketorolac tromethamine and probenecid is contraindicated. (Fachinformation zu Ketorolac, Gegenanzeigen)

Alpha 1- Adrenoreceptor Antagonist: alfuzosin Antianginal: ranolazine Antiarrhythmic: dronedarone Anti-gout: colchicine Antipsychotics: lurasidone, pimozide Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine GI Motility Agent: cisapride Hepatitis C direct acting antiviral: elbasvir/grazoprevir HMG-CoA Reductase Inhibitors: lovastatin, simvastatin… (Fachinformation zu Lopinavir und Ritonavir, Gegenanzeigen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Co-administration of Meropenem for injection with probenecid inhibits renal excretion of meropenem and is therefore not recommended ( 7.1 ) (Fachinformation zu Meropenem, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

…Interactions (7.3) ] : • Alpha 1-adrenoreceptor antagonist: alfuzosin • Antianginal: ranolazine • Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine • Anti-gout: colchicine (in patients with renal and/or hepatic impairment [see Table 2 , Drug Interactions (7.3)] ) • Antipsychotics: lurasidone, pimozide • Benign prostatic hyperplasia agents:… (Fachinformation zu Nirmatrelvir und Ritonavir, Gegenanzeigen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection and Sodium Chloride Injection unless the benefit outweighs the risk. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs. (Fachinformation zu Pralatrexat, Arzneimittelwechselwirkungen)

…Adrenoreceptor Antagonist: alfuzosin ○ Antianginal: ranolazine ○ Antiarrhythmics: amiodarone, dronedarone, flecainide, propafenone, quinidine ○ Antifungal: voriconazole ○ Anti-gout: colchicine ○ Antipsychotics: lurasidone, pimozide ○ Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine ○ GI Motility Agent: cisapride ○ HMG-CoA Reductase Inhibitors:… (Fachinformation zu Ritonavir, Gegenanzeigen)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Drug Interactions Coadministration of probenecid with intravenous acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve. (Fachinformation zu Aciclovir, Arzneimittelwechselwirkungen)

In order to prevent gout flares when treatment with allopurinol tablets is initiated, concurrent prophylactic treatment with colchicine or an anti-inflammatory agent is recommended [ see Dosage and Administration (2.2) ]. (Fachinformation zu Allopurinol, Warnhinweise und Vorsichtsmaßnahmen)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (> 1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (Fachinformation zu Amlodipin und Atorvastatin, Warnhinweise und Vorsichtsmaßnahmen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (>1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] . (Fachinformation zu Atorvastatin, Warnhinweise und Vorsichtsmaßnahmen)

Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised. (Fachinformation zu Azithromycin, Arzneimittelwechselwirkungen)

In patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) the recommended dosage should be reduced. (Fachinformation zu Baricitinib, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Fachinformation zu Bromocriptin, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Monitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )] . (Fachinformation zu Cabozantinib, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

…Immunosuppressives Other Drugs ciprofloxacin melphalan amphotericin B azapropazon cimetidine tacrolimus fibric acid derivatives (e.g., bezafibrate, fenofibrate) gentamicin ketoconazole colchicine ranitidine methotrexate tobramycin diclofenac trimethoprim with sulfamethoxazole naproxen vancomycin sulindac During the concomitant use of a drug that may exhibit additive… (Fachinformation zu Ciclosporin, Arzneimittelwechselwirkungen)

Decrease ciprofloxacin absorption, resulting in lower serum and urine levels Probenecid Use with caution (interferes with renal tubular secretion of ciprofloxacin and increases ciprofloxacin serum levels) Potentiation of ciprofloxacin toxicity may occur. (Fachinformation zu Ciprofloxacin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; and hypotension with calcium channel blockers metabolized by CYP3A4 (for example, verapamil, amlodipine, diltiazem) (see PRECAUTIONS, Drug Interactions ). (Fachinformation zu Erythromycin, Warnhinweise)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (Fachinformation zu Ezetimib und Simvastatin, Warnhinweise und Vorsichtsmaßnahmen)

Probenecid: May increase penciclovir levels. (Fachinformation zu Famciclovir, Arzneimittelwechselwirkungen)

In order to prevent gout flares when ULORIC is initiated, concurrent prophylactic treatment with an NSAID or colchicine is recommended [see Dosage and Administration (2.4) ]. (Fachinformation zu Febuxostat, Warnhinweise und Vorsichtsmaßnahmen)

Consider whether the benefit of using colchicine concomitantly with fenofibrate outweighs the increased risk of myopathy [see Drug Interactions (7) ]. (Fachinformation zu Fenofibrat, Warnhinweise und Vorsichtsmaßnahmen)

Consider whether the benefit of using colchicine concomitantly with fenofibric acid delayed-release capsules outweighs the increased risk of myopathy [see Drug Interactions (7) ] . (Fachinformation zu Fenofibrinsäure, Warnhinweise und Vorsichtsmaßnahmen)

When used concomitantly with fluvastatin sodium extended-release tablets, lipid modifying doses (≥ 1 g/day) of niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1 )] . (Fachinformation zu Fluvastatin, Warnhinweise und Vorsichtsmaßnahmen)

Fosamprenavir calcium/ritonavir and coadministration of colchicine: Treatment of gout flares: 0.6 mg (1 tablet) x 1 dose, followed by 0.3 mg (half tablet) 1 hour later. (Fachinformation zu Fosamprenavir, Arzneimittelwechselwirkungen)

Probenecid ↑Ganciclovir Ganciclovir for Injection dose may need to be reduced. (Fachinformation zu Ganciclovir, Arzneimittelwechselwirkungen)

(G) Colchicine Myopathy, including rhabdomyolysis, has been reported with chronic administration of colchicine at therapeutic doses. (Fachinformation zu Gemfibrozil, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Probenecid Clinical Impact: When indomethacin is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. (Fachinformation zu Indometacin, Arzneimittelwechselwirkungen)

In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Renal clearance of ucb L057 in the presence of probenecid decreased 60%, probably related to competitive inhibition of tubular secretion of ucb L057. (Fachinformation zu Levetiracetam, Arzneimittelwechselwirkungen)

However, these changes do not warrant dosage adjustment for Levofloxacin in 5% Dextrose Injection when probenecid or cimetidine is co-administered. (Fachinformation zu Levofloxacin, Arzneimittelwechselwirkungen)

Coadministration of lomitapide with P-gp substrates (such as aliskiren, ambrisentan, colchicine, dabigatran etexilate, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan) may increase the absorption of P-gp substrates. (Fachinformation zu Lomitapid, Arzneimittelwechselwirkungen)

Colchicine: Cases of myopathy, including rhabdomyolysis, have been reported with lovastatin coadministered with colchicine, and caution should be exercised when prescribing lovastatin with colchicine (see PRECAUTIONS , Drug Interactions ). (Fachinformation zu Lovastatin, Warnhinweise)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid increases plasma concentrations of methotrexate in both animals and humans. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (Fachinformation zu Naproxen, Arzneimittelwechselwirkungen)

Probenecid : May inhibit renal excretion of metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine; monitor for potential neurotoxicity. (Fachinformation zu Natriumphenylbutyrat, Arzneimittelwechselwirkungen)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

The following drugs when used concomitantly with LIVALO may also increase the risk of myopathy and rhabdomyolysis: lipid-modifying dosages of niacin (>1grams/day), fibrates, and colchicine [see Drug Interactions (7) ]. (Fachinformation zu Pitavastatin, Warnhinweise und Vorsichtsmaßnahmen)

The following drugs when used concomitantly with pravastatin sodium may also increase the risk of myopathy and rhabdomyolysis: niacin, fibrates, and colchicine [see Drug Interactions ( 7 )]. (Fachinformation zu Pravastatin, Warnhinweise und Vorsichtsmaßnahmen)

Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of rifampin toxicities. (Fachinformation zu Rifampicin, Arzneimittelwechselwirkungen)

Niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1) ]. (Fachinformation zu Rosuvastatin, Warnhinweise und Vorsichtsmaßnahmen)

Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1) ] . (Fachinformation zu Simvastatin, Warnhinweise und Vorsichtsmaßnahmen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. (Fachinformation zu Sumatriptan und Naproxen, Arzneimittelwechselwirkungen)

Organic Anion Drugs Coadministration of organic anion drugs (e.g., probenecid) that undergo significant renal tubular secretion have the potential to reduce secretion of torsemide into the proximal tubule and thereby decreases the diuretic activity of torsemide. (Fachinformation zu Torasemid, Arzneimittelwechselwirkungen)

In patients on probenecid and colchicine who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (Fachinformation zu Probenecid und Colchicin, Warnhinweise)

Didanosine ↔ Ganciclovir ↑ Didanosine Patients should be closely monitored for didanosine toxicity (e.g., pancreatitis) Probenecid ↑ Ganciclovir Valganciclovir hydrochloride dose may need to be reduced. (Fachinformation zu Valganciclovir, Arzneimittelwechselwirkungen)

Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol). (Fachinformation zu Carbidopa, Levodopa und Entacapon, Arzneimittelwechselwirkungen)

These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin, and chloramphenicol). (Fachinformation zu Entacapon, Vorsichtsmaßnahmen)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid Probenecid is a blocker of renal tubular secretion. (Fachinformation zu Gabapentin, Arzneimittelwechselwirkungen)

Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA. (Fachinformation zu Glycerolphenylbutyrat, Arzneimittelwechselwirkungen)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect renal excretion of phenylacetylglutamine and hippurate. (Fachinformation zu Natriumphenylacetat und Natriumbenzoat, Arzneimittelwechselwirkungen)

Uricosuric Drugs Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. (Fachinformation zu Nitrofurantoin, Arzneimittelwechselwirkungen)

Probenecid The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. (Fachinformation zu Ofloxacin, Arzneimittelwechselwirkungen)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

…hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol (see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories–propoxyphene, aspirin, indomethacin,… (Fachinformation zu Prazosin, Arzneimittelwechselwirkungen)

The uricosuric action of probenecid is also antagonized by pyrazinamide. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. (Fachinformation zu Probenecid und Colchicin, Arzneimittelwechselwirkungen)

Probenecid does not affect renal tubular transport of gentamicin. (Fachinformation zu Gentamicin, Arzneimittelwechselwirkungen)

Examples Acyclovir, ganciclovir, probenecid, valacyclovir, valganciclovir Combination Oral Contraceptives Clinical Impact Concomitant use with mycophenolate mofetil decreased the systemic exposure to levonorgestrel, but did not affect the systemic exposure to ethinylestradiol [see Clinical Pharmacology ( 12.3 )], which may result in reduced combination oral contraceptive… (Fachinformation zu Mycophenolat, Arzneimittelwechselwirkungen)