Interações de Alprostadil

• Benzyl alcohol: Serious and fatal adverse reactions can occur in neonates and low birth weight infants treated with benzyl alcohol-preserved formulations in infusion solutions, including CAVERJECT. (bula de Alprostadil, Advertências e precauções)

Ketorolac tromethamine is contraindicated in labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage. (bula de Cetorolaco, Contraindicações)

…fatal, anaphylactic reactions to NSAIDs have been reported in such patients [see Warnings and Precautions (5.8 , 5.9) ] • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac sodium and misoprostol, other prostaglandins, or any components of the drug product [see Warnings and Precautions (5.8 , 5.10) ] • Pregnancy ( 4 ) (bula de Diclofenaco + misoprostol, Contraindicações)

The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (bula de Latanoprosta, Interações medicamentosas)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Ácido mefenâmico, Advertências e precauções)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (bula de Adenosina, Advertências e precauções)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (bula de Anlodipino + valsartana, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (bula de Atenolol, Interações medicamentosas)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (bula de Atenolol + clortalidona, Interações medicamentosas)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (bula de Avanafila, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (bula de Captopril, Precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Celecoxibe, Advertências e precauções)

A second form of renal toxicity has been seen in patients with conditions leading to a reduction in renal blood flow or blood volume, where renal prostaglandins have a supportive role in the maintenance of renal blood flow. (bula de Cetoprofeno, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (bula de Dexmedetomidina, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Diclofenaco, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Diflunisal, Advertências)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (bula de Dinitrato de isossorbida, Interações medicamentosas)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (bula de Epoprostenol, Interações medicamentosas)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Etodolaco, Advertências)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Fenoprofeno, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Flurbiprofeno, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. (bula de Furosemida, Interações medicamentosas)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Renal Toxicity and Hyperkalemia Renal Toxicity Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Hidrocodona + ibuprofeno, Advertências)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Ibuprofeno, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Ibuprofeno + famotidina, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Indometacina, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Meloxicam, Advertências e precauções)

Caution should be exercised when methylergonovine maleate is used concurrently with other vasoconstrictors, ergot alkaloids, or prostaglandins. (bula de Metilergometrina, Interações medicamentosas)

The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. (bula de Mononitrato de isossorbida, Interações medicamentosas)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Nabumetona, Advertências)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Naproxeno, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Naproxeno + esomeprazol, Advertências e precauções)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (bula de Nifedipino, Interações medicamentosas)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Oxaprozina, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Paracetamol + ibuprofeno, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Piroxicam, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Salsalato, Advertências)

Blood Pressure Decreases Patients with left ventricular outflow obstruction (e.g., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure can be sensitive to the actions of vasodilators, including SILDENAFIL ORAL FILM. (bula de Sildenafila, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.In these patients, administration of a non-steroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. (bula de Sulindaco, Advertências)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Sumatriptana + naproxeno, Advertências e precauções)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (bula de Tadalafila, Advertências e precauções)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (bula de Tolmetina, Advertências)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (bula de Vardenafila, Advertências e precauções)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (bula de Alprostadil, Advertências e precauções)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (bula de Verapamil, Interações medicamentosas)

Phosphodiesterase-5 (PDE5) Inhibitors: PDE5-inhibitors are also vasodilators. (bula de Alfuzosina, Advertências e precauções)

Evidence from animal studies has suggested that certain other prostaglandins have some teratogenic potential. (bula de Carboprosta, Advertências)

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. (bula de Cloreto de potássio, Interações medicamentosas)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (bula de Dutasterida + tansulosina, Advertências e precauções)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (bula de Epinefrina (adrenalina), Interações medicamentosas)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (bula de Metoexital, Advertências)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (bula de Silodosina, Advertências e precauções)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (bula de Tansulosina, Advertências e precauções)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (bula de Treprostinila, Advertências e precauções)