Interaksi Alprostadil

• Benzyl alcohol: Serious and fatal adverse reactions can occur in neonates and low birth weight infants treated with benzyl alcohol-preserved formulations in infusion solutions, including CAVERJECT. (label Alprostadil, Peringatan dan perhatian)

…fatal, anaphylactic reactions to NSAIDs have been reported in such patients [see Warnings and Precautions (5.8 , 5.9) ] • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac sodium and misoprostol, other prostaglandins, or any components of the drug product [see Warnings and Precautions (5.8 , 5.10) ] • Pregnancy ( 4 ) (label Diklofenak dan misoprostol, Kontraindikasi)

Ketorolac tromethamine is contraindicated in labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage. (label Ketorolak, Kontraindikasi)

The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (label Latanoprost, Interaksi obat)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (label Adenosin, Peringatan dan perhatian)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (label Amlodipin dan valsartan, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Asam mefenamat, Peringatan dan perhatian)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (label Atenolol, Interaksi obat)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (label Atenolol dan klortalidon, Interaksi obat)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (label Avanafil, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (label Deksmedetomidin, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Diflunisal, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Diklofenak, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (label Epoprostenol, Interaksi obat)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Etodolak, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Fenoprofen, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Flurbiprofen, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. (label Furosemid, Interaksi obat)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Renal Toxicity and Hyperkalemia Renal Toxicity Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Hidrokodon dan ibuprofen, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Ibuprofen, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Ibuprofen dan famotidin, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Indometasin, Peringatan dan perhatian)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (label Isosorbid dinitrat, Interaksi obat)

The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. (label Isosorbid mononitrat, Interaksi obat)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (label Kaptopril, Perhatian)

A second form of renal toxicity has been seen in patients with conditions leading to a reduction in renal blood flow or blood volume, where renal prostaglandins have a supportive role in the maintenance of renal blood flow. (label Ketoprofen, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Meloksikam, Peringatan dan perhatian)

Caution should be exercised when methylergonovine maleate is used concurrently with other vasoconstrictors, ergot alkaloids, or prostaglandins. (label Metilergometrin, Interaksi obat)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Nabumeton, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Naproksen, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Naproksen dan esomeprazol, Peringatan dan perhatian)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (label Nifedipin, Interaksi obat)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Oksaprozin, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Parasetamol dan ibuprofen, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Piroksikam, Peringatan dan perhatian)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Salsalat, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Selekoksib, Peringatan dan perhatian)

Blood Pressure Decreases Patients with left ventricular outflow obstruction (e.g., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure can be sensitive to the actions of vasodilators, including SILDENAFIL ORAL FILM. (label Sildenafil, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.In these patients, administration of a non-steroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. (label Sulindak, Peringatan)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Sumatriptan dan naproksen, Peringatan dan perhatian)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (label Tadalafil, Peringatan dan perhatian)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (label Tolmetin, Peringatan)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (label Vardenafil, Peringatan dan perhatian)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (label Verapamil, Interaksi obat)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (label Alprostadil, Peringatan dan perhatian)

Phosphodiesterase-5 (PDE5) Inhibitors: PDE5-inhibitors are also vasodilators. (label Alfuzosin, Peringatan dan perhatian)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (label Dutasterid dan tamsulosin, Peringatan dan perhatian)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (label Epinefrin, Interaksi obat)

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. (label Kalium klorida, Interaksi obat)

Evidence from animal studies has suggested that certain other prostaglandins have some teratogenic potential. (label Karboprost, Peringatan)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (label Metoheksital, Peringatan)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (label Silodosin, Peringatan dan perhatian)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (label Tamsulosin, Peringatan dan perhatian)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (label Treprostinil, Peringatan dan perhatian)