Interações de Dextrometorfano

Dextrometorfano (Delsym, Robitussin), medicamento serotoninérgico, tem 79 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 61; moderadas: 7; leves: 8; casos em que uma bula relata não haver interação significativa: 3). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (61)

  • Anfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Anfetamina, Advertências e precauções)

  • Anfetamina + dextroanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans), but also during overdosage situations. (bula de Anfetamina + dextroanfetamina, Advertências e precauções)

  • Azul de metilenoinibidor da MAOGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • Beladona + ópioopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Beladona + ópio, Interações medicamentosas)

  • BuprenorfinaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Buprenorfina, Interações medicamentosas)

  • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Buprenorfina + naloxona, Interações medicamentosas)

  • Buspironamedicamento serotoninérgicoGrave

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs SSRIs, and other serotonergic drugs, including buspirone, alone but particularly with concomitant use of other serotonergic drugs (including triptans), with drugs that impair metabolism of serotonin (in particular, MAOIs, including reversible MAOIs… (bula de Buspirona, Advertências)

  • Intervention: Avoid concomitant use Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Butalbital + ácido acetilsalicílico + cafeína + codeína, Interações medicamentosas)

  • • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Butalbital + paracetamol + cafeína + codeína, Interações medicamentosas)

  • ButorfanolopioideGrave

    …medical attention if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see WARNINGS ; ADVERSE REACTIONS ].‎ Serotonin Syndrome Inform patients that butorphanol tartrate could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Butorfanol, Precauções)

  • Ciclobenzaprinarelaxante muscularGrave

    If serotonin syndrome symptoms occur with the use of other serotonergic drugs, immediately discontinue TONMYA. (bula de Ciclobenzaprina, Interações medicamentosas)

  • CitalopramISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Citalopram, Advertências e precauções)

  • CodeínaopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Codeína, Interações medicamentosas)

  • • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Desvenlafaxina, Advertências e precauções)

  • Dextroanfetaminaestimulante do SNCGrave

    Serotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans,… (bula de Dextroanfetamina, Advertências)

  • DuloxetinaIRSNGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents but also when taken alone. (bula de Duloxetina, Advertências e precauções)

  • Erva-de-são-joão (hipérico)Fitoterápicos e suplementosGrave

    Combinar a erva-de-são-joão (hipérico) com antidepressivos e outros medicamentos serotoninérgicos aumenta o risco de síndrome serotoninérgica. (NCCIH, St. John's Wort)

  • EscitalopramISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents but also when taken alone. (bula de Escitalopram, Advertências e precauções)

  • Fenelzinainibidor da MAOGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • FentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Fentanila, Advertências e precauções)

  • FluoxetinaISRSGrave

    If concomitant use of PROZAC with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases ( 5.2 ) (bula de Fluoxetina, Advertências e precauções)

  • FluvoxaminaISRSGrave

    If concomitant use of Fluvoxamine Maleate Tablets with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. (bula de Fluvoxamina, Advertências e precauções)

  • Granisetronamedicamento que prolonga o intervalo QTGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of granisetron and other serotonergic drugs. (bula de Granisetrona, Advertências e precauções)

  • HidrocodonaopioideGrave

    Example: lactulose Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona, Interações medicamentosas)

  • Serotonergic drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + clorfeniramina, Interações medicamentosas)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + homatropina, Interações medicamentosas)

  • S er otonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Hidrocodona + ibuprofeno, Precauções)

  • Serotonin Syndrome Inform patients that hydrocodone bitartrate and acetaminophen tablets could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Hidrocodona + paracetamol, Precauções)

  • HidromorfonaopioideGrave

    • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidromorfona, Interações medicamentosas)

  • IsoniazidaantibióticoGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Levomilnaciprana, Advertências e precauções)

  • LevorfanolopioideGrave

    Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Levorfanol, Precauções)

  • LinezolidaantibióticoGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • Lisdexanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Lisdexanfetamina, Advertências e precauções)

  • Lítiomedicamento serotoninérgicoGrave

    If concomitant use of lithium with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms. (bula de Lítio, Advertências e precauções)

  • MetadonaopioideGrave

    Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Metadona, Advertências e precauções)

  • Metanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Metanfetamina, Advertências e precauções)

  • Metaxalonarelaxante muscularGrave

    Serotonin syndrome has resulted from concomitant use of metaxalone (within the recommended dosage range) and other serotonergic drugs [see Warnings and Precautions (5.1) ]. (bula de Metaxalona, Interações medicamentosas)

  • MilnacipranaIRSNGrave

    • Serotonin Syndrome : Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Milnaciprana, Advertências e precauções)

  • MirtazapinaantidepressivoGrave

    Serotonin Syndrome : Increased risk when co-administered with other serotonergic drugs (e.g., SSRI, SNRI, triptans), but also when taken alone. (bula de Mirtazapina, Advertências e precauções)

  • MorfinaopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Morfina, Interações medicamentosas)

  • Olanzapina + fluoxetinaantipsicóticoGrave

    If concomitant use of olanzapine and fluoxetine capsules with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases ( 5.6 ) (bula de Olanzapina + fluoxetina, Advertências e precauções)

  • OliceridinaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Oliceridina, Interações medicamentosas)

  • Ondansetronamedicamento que prolonga o intervalo QTGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of Ondansetron Injection and other serotonergic drugs. (bula de Ondansetrona, Advertências e precauções)

  • OxicodonaopioideGrave

    Serotonergic Drug s: Concomitant use may result in serotonin syndrome. (bula de Oxicodona, Interações medicamentosas)

  • OximorfonaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Oximorfona, Interações medicamentosas)

  • Palonosetronamedicamento serotoninérgicoGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of POSFREA and other serotonergic drugs. (bula de Palonosetrona, Advertências e precauções)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Paracetamol + codeína, Precauções)

  • ParoxetinaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Paroxetina, Advertências e precauções)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Pentazocina + naloxona, Precauções)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Prometazina + codeína, Interações medicamentosas)

  • Rasagilinainibidor da MAOGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • RemifentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Remifentanila, Advertências e precauções)

  • Selegilinainibidor da MAOGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • SertralinaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Tranilciprominainibidor da MAOGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Dextrometorfano, Advertências)

  • TrazodonaantidepressivoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. (bula de Trazodona, Advertências e precauções)

  • VenlafaxinaIRSNGrave

    If concomitant use of Venlafaxine Extended Release Tablets with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. (bula de Venlafaxina, Advertências e precauções)

  • VilazodonaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Vilazodona, Advertências e precauções)

  • VortioxetinaantidepressivoGrave

    • Serotonin Syndrome : Increased risk when coadministered with other serotonergic agents, but also when taken alone. (bula de Vortioxetina, Advertências e precauções)

  • ZiprasidonaantipsicóticoGrave

    • Serotonin Syndrome : Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Ziprasidona, Advertências e precauções)

Interações moderadas (7)

  • MemantinaModerada

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (bula de Memantina, Interações medicamentosas)

  • Memantina + donepezilainibidor da colinesteraseModerada

    Use of Memantine with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (bula de Memantina + donepezila, Interações medicamentosas)

  • NalbufinaopioideModerada

    Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system… (bula de Nalbufina, Interações medicamentosas)

  • QuininaantimaláricoModerada

    Although clinical drug interaction studies have not been performed, antimalarial doses (greater than or equal to 600 mg) of quinine may inhibit the metabolism of other drugs that are CYP2D6 substrates (e.g., flecainide, debrisoquine, dextromethorphan, metoprolol, paroxetine ). (bula de Quinina, Interações medicamentosas)

  • Rolapitantoinibidor da CYP2D6Moderada

    Exposure to dextromethorphan, a CYP2D6 substrate, following a single dose of rolapitant increased about 3-fold on Days 8 and Day 22. (bula de Rolapitanto, Advertências e precauções)

  • TerbinafinaantifúngicoModerada

    In studies in healthy subjects characterized as extensive metabolizers of dextromethorphan (antitussive drug and CYP2D6 probe substrate), terbinafine increases the dextromethorphan/ dextrorphan metabolite ratio in urine by 16- to 97-fold on average. (bula de Terbinafina, Interações medicamentosas)

  • TramadolopioideModerada

    …and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol Serotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome [see Warnings… (bula de Tramadol, Interações medicamentosas)

Menções leves (8)

  • Clomipraminaantidepressivo tricíclicoLeve

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including clomipramine hydrochloride capsules, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (bula de Clomipramina, Advertências)

  • Desipraminaantidepressivo tricíclicoLeve

    …Syndrome: The development of a potentially life-threatening serotonin syndrome has been reported with serotonin norepinephrine re-uptake inhibitors (SNRIs) and SSRIs, including NORPRAMIN, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (bula de Desipramina, Advertências)

  • Fenterminaestimulante do SNCLeve

    The safety and efficacy of combination therapy with phentermine and any other drug products for weight loss including prescribed drugs, over-the-counter preparations, and herbal products, or serotonergic agents such as selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. (bula de Fentermina, Advertências e precauções)

  • NefazodonaantidepressivoLeve

    Such individuals are referred to commonly as “poor metabolizers” of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants. (bula de Nefazodona, Interações medicamentosas)

  • Nortriptilinaantidepressivo tricíclicoLeve

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including Pamelor, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (bula de Nortriptilina, Advertências)

  • Serotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome [see Adverse Reaction ( 6.2)]. (bula de Oxicodona + paracetamol, Interações medicamentosas)

  • Tabaco e fumoTabaco e cannabisLeve

    Ask a doctor before use if you have chronic cough that lasts such as occurs with smoking, asthma, or emphysema cough that occurs with too much phlegm (mucus) Stop use and ask a doctor if cough lasts more than 7 days, comes back, or occurs with fever, rash, or headache that lasts. (bula de Dextrometorfano, Advertências)

  • Trimipraminaantidepressivo tricíclicoLeve

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including trimipramine capsules, alone, but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (bula de Trimipramina, Advertências)

Nenhuma interação significativa relatada (3)

  • AripiprazolantipsicóticoSem interação

    In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin), or CYP3A4 (e.g., dextromethorphan) when coadministered with ABILIFY MAINTENA. (bula de Aripiprazol, Interações medicamentosas)

  • BrexpiprazolantipsicóticoSem interação

    Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI. (bula de Brexpiprazol, Interações medicamentosas)

  • Metilnaltrexonaantagonista opioideSem interação

    Drugs Metabolized by Cytochrome P450 Isozymes In healthy subjects, a subcutaneous dose of 0.3 mg/kg of RELISTOR did not significantly affect the metabolism of dextromethorphan, a CYP2D6 substrate. (bula de Metilnaltrexona, Interações medicamentosas)

Verifique Dextrometorfano com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

Abrir no verificador

Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.