Interaksi Dekstrometorfan

Dekstrometorfan (Delsym, Robitussin), golongan obat serotonergik, memiliki 79 interaksi terdokumentasi dalam label FDA dan lembar fakta yang kami indeks: 61 mayor, 7 moderat, 8 minor, dan 3 dengan label yang melaporkan tidak ada interaksi bermakna. Setiap entri di bawah ini mengutip kalimat yang mendasarinya. Halaman obat ini adalah titik awal, bukan putusan untuk situasi Anda.

Interaksi dari label

Interaksi mayor (61)

  • Amfetaminstimulan SSPMayor

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (label Amfetamin, Peringatan dan perhatian)

  • Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans), but also during overdosage situations. (label Amfetamin dan dekstroamfetamin, Peringatan dan perhatian)

  • • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (label Beladona dan opium, Interaksi obat)

  • BuprenorfinopioidMayor

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Buprenorfin, Interaksi obat)

  • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (label Buprenorfin dan nalokson, Interaksi obat)

  • Buspironobat serotonergikMayor

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs SSRIs, and other serotonergic drugs, including buspirone, alone but particularly with concomitant use of other serotonergic drugs (including triptans), with drugs that impair metabolism of serotonin (in particular, MAOIs, including reversible MAOIs… (label Buspiron, Peringatan)

  • Intervention: Avoid concomitant use Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Butalbital, aspirin, kafein, dan kodein, Interaksi obat)

  • • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (label Butalbital, parasetamol, kafein, dan kodein, Interaksi obat)

  • ButorfanolopioidMayor

    …medical attention if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see WARNINGS ; ADVERSE REACTIONS ].‎ Serotonin Syndrome Inform patients that butorphanol tartrate could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Butorfanol, Perhatian)

  • Dekstroamfetaminstimulan SSPMayor

    Serotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans,… (label Dekstroamfetamin, Peringatan)

  • • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Desvenlafaksin, Peringatan dan perhatian)

  • DuloksetinSNRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents but also when taken alone. (label Duloksetin, Peringatan dan perhatian)

  • EsitalopramSSRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents but also when taken alone. (label Esitalopram, Peringatan dan perhatian)

  • Fenelzinpenghambat MAOMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • FentanilopioidMayor

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (label Fentanil, Peringatan dan perhatian)

  • FluoksetinSSRIMayor

    If concomitant use of PROZAC with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases ( 5.2 ) (label Fluoksetin, Peringatan dan perhatian)

  • FluvoksaminSSRIMayor

    If concomitant use of Fluvoxamine Maleate Tablets with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. (label Fluvoksamin, Peringatan dan perhatian)

  • Granisetronobat yang memperpanjang interval QTMayor

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of granisetron and other serotonergic drugs. (label Granisetron, Peringatan dan perhatian)

  • HidrokodonopioidMayor

    Example: lactulose Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Hidrokodon, Interaksi obat)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Hidrokodon dan homatropin, Interaksi obat)

  • S er otonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Hidrokodon dan ibuprofen, Perhatian)

  • Serotonergic drugs : Concomitant use may result in serotonin syndrome. (label Hidrokodon dan klorfeniramin, Interaksi obat)

  • Serotonin Syndrome Inform patients that hydrocodone bitartrate and acetaminophen tablets could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Hidrokodon dan parasetamol, Perhatian)

  • HidromorfonopioidMayor

    • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Hidromorfon, Interaksi obat)

  • IsoniazidantibiotikMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • KodeinopioidMayor

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (label Kodein, Interaksi obat)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Levomilnasipran, Peringatan dan perhatian)

  • LevorfanolopioidMayor

    Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Levorfanol, Perhatian)

  • LinezolidantibiotikMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • Lisdeksamfetaminstimulan SSPMayor

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (label Lisdeksamfetamin, Peringatan dan perhatian)

  • Litiumobat serotonergikMayor

    If concomitant use of lithium with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms. (label Litium, Peringatan dan perhatian)

  • MetadonopioidMayor

    Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (label Metadon, Peringatan dan perhatian)

  • Metaksalonpelemas ototMayor

    Serotonin syndrome has resulted from concomitant use of metaxalone (within the recommended dosage range) and other serotonergic drugs [see Warnings and Precautions (5.1) ]. (label Metaksalon, Interaksi obat)

  • Metamfetaminstimulan SSPMayor

    Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (label Metamfetamin, Peringatan dan perhatian)

  • Metilen birupenghambat MAOMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • MilnasipranSNRIMayor

    • Serotonin Syndrome : Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Milnasipran, Peringatan dan perhatian)

  • MirtazapinantidepresanMayor

    Serotonin Syndrome : Increased risk when co-administered with other serotonergic drugs (e.g., SSRI, SNRI, triptans), but also when taken alone. (label Mirtazapin, Peringatan dan perhatian)

  • MorfinopioidMayor

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (label Morfin, Interaksi obat)

  • OksikodonopioidMayor

    Serotonergic Drug s: Concomitant use may result in serotonin syndrome. (label Oksikodon, Interaksi obat)

  • OksimorfonopioidMayor

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Oksimorfon, Interaksi obat)

  • Olanzapin dan fluoksetinantipsikotikMayor

    If concomitant use of olanzapine and fluoxetine capsules with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases ( 5.6 ) (label Olanzapin dan fluoksetin, Peringatan dan perhatian)

  • OliseridinopioidMayor

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Oliseridin, Interaksi obat)

  • Ondansetronobat yang memperpanjang interval QTMayor

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of Ondansetron Injection and other serotonergic drugs. (label Ondansetron, Peringatan dan perhatian)

  • Palonosetronobat serotonergikMayor

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of POSFREA and other serotonergic drugs. (label Palonosetron, Peringatan dan perhatian)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Parasetamol dan kodein, Perhatian)

  • ParoksetinSSRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Paroksetin, Peringatan dan perhatian)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (label Pentazosin dan nalokson, Perhatian)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (label Prometazin dan kodein, Interaksi obat)

  • Rasagilinpenghambat MAOMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • RemifentanilopioidMayor

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (label Remifentanil, Peringatan dan perhatian)

  • Selegilinpenghambat MAOMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • SertralinSSRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Sertralin, Peringatan dan perhatian)

  • Siklobenzaprinpelemas ototMayor

    If serotonin syndrome symptoms occur with the use of other serotonergic drugs, immediately discontinue TONMYA. (label Siklobenzaprin, Interaksi obat)

  • SitalopramSSRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Sitalopram, Peringatan dan perhatian)

  • St. John's wortHerbal dan suplemenMayor

    Mengombinasikan St. John's wort dengan antidepresan dan obat serotonergik lain meningkatkan risiko sindrom serotonin. (NCCIH, St. John's Wort)

  • Tranilsiprominpenghambat MAOMayor

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (label Dekstrometorfan, Peringatan)

  • TrazodonantidepresanMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. (label Trazodon, Peringatan dan perhatian)

  • VenlafaksinSNRIMayor

    If concomitant use of Venlafaxine Extended Release Tablets with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. (label Venlafaksin, Peringatan dan perhatian)

  • VilazodonSSRIMayor

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Vilazodon, Peringatan dan perhatian)

  • VortioksetinantidepresanMayor

    • Serotonin Syndrome : Increased risk when coadministered with other serotonergic agents, but also when taken alone. (label Vortioksetin, Peringatan dan perhatian)

  • ZiprasidonantipsikotikMayor

    • Serotonin Syndrome : Increased risk when co-administered with other serotonergic agents, but also when taken alone. (label Ziprasidon, Peringatan dan perhatian)

Interaksi moderat (7)

  • KuininantimalariaModerat

    Although clinical drug interaction studies have not been performed, antimalarial doses (greater than or equal to 600 mg) of quinine may inhibit the metabolism of other drugs that are CYP2D6 substrates (e.g., flecainide, debrisoquine, dextromethorphan, metoprolol, paroxetine ). (label Kuinin, Interaksi obat)

  • MemantinModerat

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (label Memantin, Interaksi obat)

  • Memantin dan donepezilpenghambat kolinesteraseModerat

    Use of Memantine with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (label Memantin dan donepezil, Interaksi obat)

  • NalbufinopioidModerat

    Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system… (label Nalbufin, Interaksi obat)

  • Rolapitantpenghambat CYP2D6Moderat

    Exposure to dextromethorphan, a CYP2D6 substrate, following a single dose of rolapitant increased about 3-fold on Days 8 and Day 22. (label Rolapitant, Peringatan dan perhatian)

  • TerbinafinantijamurModerat

    In studies in healthy subjects characterized as extensive metabolizers of dextromethorphan (antitussive drug and CYP2D6 probe substrate), terbinafine increases the dextromethorphan/ dextrorphan metabolite ratio in urine by 16- to 97-fold on average. (label Terbinafin, Interaksi obat)

  • TramadolopioidModerat

    …and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol Serotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome [see Warnings… (label Tramadol, Interaksi obat)

Penyebutan minor (8)

  • Desipraminantidepresan trisiklikMinor

    …Syndrome: The development of a potentially life-threatening serotonin syndrome has been reported with serotonin norepinephrine re-uptake inhibitors (SNRIs) and SSRIs, including NORPRAMIN, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (label Desipramin, Peringatan)

  • Fenterminstimulan SSPMinor

    The safety and efficacy of combination therapy with phentermine and any other drug products for weight loss including prescribed drugs, over-the-counter preparations, and herbal products, or serotonergic agents such as selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. (label Fentermin, Peringatan dan perhatian)

  • Klomipraminantidepresan trisiklikMinor

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including clomipramine hydrochloride capsules, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (label Klomipramin, Peringatan)

  • NefazodonantidepresanMinor

    Such individuals are referred to commonly as “poor metabolizers” of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants. (label Nefazodon, Interaksi obat)

  • Nortriptilinantidepresan trisiklikMinor

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including Pamelor, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (label Nortriptilin, Peringatan)

  • Serotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome [see Adverse Reaction ( 6.2)]. (label Oksikodon dan parasetamol, Interaksi obat)

  • Tembakau dan merokokTembakau dan ganjaMinor

    Ask a doctor before use if you have chronic cough that lasts such as occurs with smoking, asthma, or emphysema cough that occurs with too much phlegm (mucus) Stop use and ask a doctor if cough lasts more than 7 days, comes back, or occurs with fever, rash, or headache that lasts. (label Dekstrometorfan, Peringatan)

  • Trimipraminantidepresan trisiklikMinor

    Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including trimipramine capsules, alone, but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. (label Trimipramin, Peringatan)

Tidak ada interaksi bermakna yang dilaporkan (3)

  • AripiprazolantipsikotikTanpa interaksi

    In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin), or CYP3A4 (e.g., dextromethorphan) when coadministered with ABILIFY MAINTENA. (label Aripiprazol, Interaksi obat)

  • BrekspiprazolantipsikotikTanpa interaksi

    Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI. (label Brekspiprazol, Interaksi obat)

  • Metilnaltreksonantagonis opioidTanpa interaksi

    Drugs Metabolized by Cytochrome P450 Isozymes In healthy subjects, a subcutaneous dose of 0.3 mg/kg of RELISTOR did not significantly affect the metabolism of dextromethorphan, a CYP2D6 substrate. (label Metilnaltrekson, Interaksi obat)

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