Interações de Imipeném + cilastatina

Imipeném + cilastatina (Primaxin), antibiótico, tem 60 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 32; moderadas: 27; leves: 1; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (32)

  • Ácido valproicoanticonvulsivanteGrave

    The concomitant use of PRIMAXIN and valproic acid/divalproex sodium is generally not recommended ( 5.3 , 7.3 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • Amoxicilinaantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Amoxicilina + clavulanato de potássioantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Ampicilinaantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Ampicilina + sulbactamantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Benzilpenicilina (penicilina G)antibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefaclorcefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefadroxilacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefalexinacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefazolinacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefdinircefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefepimacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefiximacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefotaximacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefotetanacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefoxitinacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefpodoximacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefprozilacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CeftarolinacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CeftazidimacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CeftriaxonacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • CefuroximacefalosporinaGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Dicloxacilinaantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Divalproato de sódio (valproato)anticonvulsivanteGrave

    The concomitant use of PRIMAXIN and valproic acid/divalproex sodium is generally not recommended ( 5.3 , 7.3 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • Fenoximetilpenicilina (penicilina V)antibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • GanciclovirantiviralGrave

    …Significant Drug Interactions with Ganciclovir for Injection Name of the Concomitant Drug Change in the Concentration of Ganciclovir or Concomitant Drug Clinical Comment Imipenem-cilastatin Unknown Coadministration with imipenem-cilastatin is not recommended because generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin. (bula de Ganciclovir, Interações medicamentosas)

  • Nafcilinaantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Oxacilinaantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Piperacilina + tazobactamantibiótico da classe das penicilinasGrave

    Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)

  • Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN. (bula de Imipeném + cilastatina, Interações medicamentosas)

  • Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN. (bula de Imipeném + cilastatina, Interações medicamentosas)

  • ValganciclovirantiviralGrave

    …Other Potentially Significant Drug Interactions with Ganciclovir Name of the Concomitant Drug Change in the Concentration of Ganciclovir or Concomitant Drug Clinical Comment Imipenem-cilastatin Unknown Coadministration with imipenem-cilastatin is not recommended because generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin. (bula de Valganciclovir, Interações medicamentosas)

Interações moderadas (27)

  • BrivaracetamanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • CarbamazepinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • CenobamatoanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • ClobazambenzodiazepínicoModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • ClonazepambenzodiazepínicoModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • EslicarbazepinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • EtossuximidaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • FelbamatoanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • FenitoínaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • FenobarbitalbarbitúricoModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • Fentermina + topiramatoestimulante do SNCModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • FosfenitoínaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • GabapentinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • LacosamidaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • LamotriginaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • LevetiracetamanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • Mesuximida (metossuximida)anticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • OxcarbazepinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • PerampanelanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • PregabalinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • PrimidonaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • RufinamidaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • TiagabinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • TopiramatoanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • VigabatrinaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

  • ZonisamidaanticonvulsivanteModerada

    If focal tremors, myoclonus, or seizures occur, patients should be evaluated neurologically, placed on anticonvulsant therapy if not already instituted, and the dosage of PRIMAXIN re-examined to determine whether it should be decreased, or the antibacterial drug discontinued ( 5.2 ). (bula de Imipeném + cilastatina, Advertências e precauções)

Menções leves (1)

  • Tigeciclinaantibiótico da classe das tetraciclinasLeve

    In cIAI studies (n=1642), 6 patients treated with TYGACIL and 2 patients treated with imipenem/cilastatin presented with intestinal perforations and developed sepsis/septic shock. (bula de Tigeciclina, Advertências e precauções)

Verifique Imipeném + cilastatina com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

Abrir no verificador

Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.